Evaluation of the antifungal efficacy of different concentrations of Curcuma longa on Candida albicans: An in vitro study
Background: Candidal infections have increased significantly in denture wearers, especially in immunocompromised patients. The increase in resistance to existing antifungal drugs and number of patients at risk, in conjunction with the restricted number of commercially available antifungal drugs that...
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| Veröffentlicht in: | Journal of oral and maxillofacial pathology : JOMFP 2019-05, Vol.23 (2), p.305-305 |
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| container_title | Journal of oral and maxillofacial pathology : JOMFP |
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| creator | Murugesh, Jeevitha Annigeri, Rajeshwari Mangala, G Mythily, P Chandrakala, J |
| description | Background: Candidal infections have increased significantly in denture wearers, especially in immunocompromised patients. The increase in resistance to existing antifungal drugs and number of patients at risk, in conjunction with the restricted number of commercially available antifungal drugs that still present many side effects, are the cause for this problem. These limitations emphasize the need to develop new and more effective antifungal agents with lesser side effects.
Materials and Methods: The present study was undertaken to investigate the possible antifungal action of the alcoholic extract of different concentrations of Curcuma longa on four dilutions of Candida albicans (1:10, 1:20, 1:40 and 1:80) and to determine its minimum inhibitory concentration (MIC) and minimum fungicidal concentration using Sabouraud's agar medium.
Results: There was complete inhibition of the growth of all four dilutions of Candida at a concentration of 800 μl which is considered as the MIC of alcoholic extract of turmeric on C. albicans, and the minimum fungicidal concentration was at 1600 μl.
Conclusion: This study indicates a potent antifungal action of C. longa against C. albicans. |
| doi_str_mv | 10.4103/jomfp.JOMFP_200_18 |
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Materials and Methods: The present study was undertaken to investigate the possible antifungal action of the alcoholic extract of different concentrations of Curcuma longa on four dilutions of Candida albicans (1:10, 1:20, 1:40 and 1:80) and to determine its minimum inhibitory concentration (MIC) and minimum fungicidal concentration using Sabouraud's agar medium.
Results: There was complete inhibition of the growth of all four dilutions of Candida at a concentration of 800 μl which is considered as the MIC of alcoholic extract of turmeric on C. albicans, and the minimum fungicidal concentration was at 1600 μl.
Conclusion: This study indicates a potent antifungal action of C. longa against C. albicans.</description><identifier>ISSN: 0973-029X</identifier><identifier>EISSN: 1998-393X</identifier><identifier>DOI: 10.4103/jomfp.JOMFP_200_18</identifier><identifier>PMID: 31516248</identifier><language>eng</language><publisher>India: Wolters Kluwer India Pvt. Ltd</publisher><subject>Alcohol ; Analysis ; Antifungal activity ; Antifungal agents ; Antimicrobial agents ; Biofilms ; Candida albicans ; Curcuma longa ; Dentures ; Drug resistance ; Drugs ; Ethanol ; Fungi ; HIV ; Human immunodeficiency virus ; Immunocompromised host ; Immunocompromised hosts ; Infection ; Infections ; Laboratories ; Minimum inhibitory concentration ; Original ; Side effects</subject><ispartof>Journal of oral and maxillofacial pathology : JOMFP, 2019-05, Vol.23 (2), p.305-305</ispartof><rights>COPYRIGHT 2019 Medknow Publications and Media Pvt. Ltd.</rights><rights>2019. This work is published under https://creativecommons.org/licenses/by-nc-sa/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright: © 2019 Journal of Oral and Maxillofacial Pathology 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c473i-851a515be62a8d8f22322f4901fbd20fb84fe53ad62e2b60b17982948edd2a6e3</citedby><cites>FETCH-LOGICAL-c473i-851a515be62a8d8f22322f4901fbd20fb84fe53ad62e2b60b17982948edd2a6e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6714268/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6714268/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27435,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31516248$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Murugesh, Jeevitha</creatorcontrib><creatorcontrib>Annigeri, Rajeshwari</creatorcontrib><creatorcontrib>Mangala, G</creatorcontrib><creatorcontrib>Mythily, P</creatorcontrib><creatorcontrib>Chandrakala, J</creatorcontrib><title>Evaluation of the antifungal efficacy of different concentrations of Curcuma longa on Candida albicans: An in vitro study</title><title>Journal of oral and maxillofacial pathology : JOMFP</title><addtitle>J Oral Maxillofac Pathol</addtitle><description>Background: Candidal infections have increased significantly in denture wearers, especially in immunocompromised patients. The increase in resistance to existing antifungal drugs and number of patients at risk, in conjunction with the restricted number of commercially available antifungal drugs that still present many side effects, are the cause for this problem. These limitations emphasize the need to develop new and more effective antifungal agents with lesser side effects.
Materials and Methods: The present study was undertaken to investigate the possible antifungal action of the alcoholic extract of different concentrations of Curcuma longa on four dilutions of Candida albicans (1:10, 1:20, 1:40 and 1:80) and to determine its minimum inhibitory concentration (MIC) and minimum fungicidal concentration using Sabouraud's agar medium.
Results: There was complete inhibition of the growth of all four dilutions of Candida at a concentration of 800 μl which is considered as the MIC of alcoholic extract of turmeric on C. albicans, and the minimum fungicidal concentration was at 1600 μl.
Conclusion: This study indicates a potent antifungal action of C. longa against C. albicans.</description><subject>Alcohol</subject><subject>Analysis</subject><subject>Antifungal activity</subject><subject>Antifungal agents</subject><subject>Antimicrobial agents</subject><subject>Biofilms</subject><subject>Candida albicans</subject><subject>Curcuma longa</subject><subject>Dentures</subject><subject>Drug resistance</subject><subject>Drugs</subject><subject>Ethanol</subject><subject>Fungi</subject><subject>HIV</subject><subject>Human immunodeficiency virus</subject><subject>Immunocompromised host</subject><subject>Immunocompromised hosts</subject><subject>Infection</subject><subject>Infections</subject><subject>Laboratories</subject><subject>Minimum inhibitory concentration</subject><subject>Original</subject><subject>Side effects</subject><issn>0973-029X</issn><issn>1998-393X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kktvEzEUhUcIREPhD7BAltiwSfBzxmaBFIU-QEVlAVJ3lmdst049dmrPJMq_x2na0iKEvLiS73eOfe1TVW8RnFEEycdl7O1q9u38-_EPiSGUiD-rJkgIPiWCXDyvJlA0ZAqxuDioXuW8hJBxyvDL6oAghmpM-aTaHq2VH9XgYgDRguHKABUGZ8dwqTww1rpOddtdSztrTTJhAF0MXanpVpV3vcWYurFXwMciA8VqoYJ2WgHl22IQ8icwD8AFsHZDiiAPo96-rl5Y5bN5c1cPq1_HRz8Xp9Oz85Ovi_nZtKMNcVPOkGKItabGimtuMSYYWyogsq3G0LacWsOI0jU2uK1hixrBsaDcaI1Vbchh9Xnvuxrb3uj9zb1cJdertJVROfm0E9yVvIxrWTeI4poXgw93BinejCYPsne5M96rYOKYJcYCckYhIQV9_xe6jGMKZbxCNXWDCYXsD1We2EgXbCzndjtTOWeiFoRjTgs1-wdVlja9K19grCv7TwR4L-hSzDkZ-zAjgnIXGHkbGPk4MEX07vHrPEjuE1KAL3tgE_1gUr7248YkWdjrEDf_sZYEMnmfLvIb65zW0Q</recordid><startdate>20190501</startdate><enddate>20190501</enddate><creator>Murugesh, Jeevitha</creator><creator>Annigeri, Rajeshwari</creator><creator>Mangala, G</creator><creator>Mythily, P</creator><creator>Chandrakala, J</creator><general>Wolters Kluwer India Pvt. 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Annigeri, Rajeshwari ; Mangala, G ; Mythily, P ; Chandrakala, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c473i-851a515be62a8d8f22322f4901fbd20fb84fe53ad62e2b60b17982948edd2a6e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Alcohol</topic><topic>Analysis</topic><topic>Antifungal activity</topic><topic>Antifungal agents</topic><topic>Antimicrobial agents</topic><topic>Biofilms</topic><topic>Candida albicans</topic><topic>Curcuma longa</topic><topic>Dentures</topic><topic>Drug resistance</topic><topic>Drugs</topic><topic>Ethanol</topic><topic>Fungi</topic><topic>HIV</topic><topic>Human immunodeficiency virus</topic><topic>Immunocompromised host</topic><topic>Immunocompromised hosts</topic><topic>Infection</topic><topic>Infections</topic><topic>Laboratories</topic><topic>Minimum inhibitory concentration</topic><topic>Original</topic><topic>Side effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Murugesh, Jeevitha</creatorcontrib><creatorcontrib>Annigeri, Rajeshwari</creatorcontrib><creatorcontrib>Mangala, G</creatorcontrib><creatorcontrib>Mythily, P</creatorcontrib><creatorcontrib>Chandrakala, J</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of oral and maxillofacial pathology : JOMFP</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Murugesh, Jeevitha</au><au>Annigeri, Rajeshwari</au><au>Mangala, G</au><au>Mythily, P</au><au>Chandrakala, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of the antifungal efficacy of different concentrations of Curcuma longa on Candida albicans: An in vitro study</atitle><jtitle>Journal of oral and maxillofacial pathology : JOMFP</jtitle><addtitle>J Oral Maxillofac Pathol</addtitle><date>2019-05-01</date><risdate>2019</risdate><volume>23</volume><issue>2</issue><spage>305</spage><epage>305</epage><pages>305-305</pages><issn>0973-029X</issn><eissn>1998-393X</eissn><abstract>Background: Candidal infections have increased significantly in denture wearers, especially in immunocompromised patients. The increase in resistance to existing antifungal drugs and number of patients at risk, in conjunction with the restricted number of commercially available antifungal drugs that still present many side effects, are the cause for this problem. These limitations emphasize the need to develop new and more effective antifungal agents with lesser side effects.
Materials and Methods: The present study was undertaken to investigate the possible antifungal action of the alcoholic extract of different concentrations of Curcuma longa on four dilutions of Candida albicans (1:10, 1:20, 1:40 and 1:80) and to determine its minimum inhibitory concentration (MIC) and minimum fungicidal concentration using Sabouraud's agar medium.
Results: There was complete inhibition of the growth of all four dilutions of Candida at a concentration of 800 μl which is considered as the MIC of alcoholic extract of turmeric on C. albicans, and the minimum fungicidal concentration was at 1600 μl.
Conclusion: This study indicates a potent antifungal action of C. longa against C. albicans.</abstract><cop>India</cop><pub>Wolters Kluwer India Pvt. Ltd</pub><pmid>31516248</pmid><doi>10.4103/jomfp.JOMFP_200_18</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of oral and maxillofacial pathology : JOMFP, 2019-05, Vol.23 (2), p.305-305 |
| issn | 0973-029X 1998-393X |
| language | eng |
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| source | Medknow Open Access Medical Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Alcohol Analysis Antifungal activity Antifungal agents Antimicrobial agents Biofilms Candida albicans Curcuma longa Dentures Drug resistance Drugs Ethanol Fungi HIV Human immunodeficiency virus Immunocompromised host Immunocompromised hosts Infection Infections Laboratories Minimum inhibitory concentration Original Side effects |
| title | Evaluation of the antifungal efficacy of different concentrations of Curcuma longa on Candida albicans: An in vitro study |
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