Bisubstrate Inhibitors of Nicotinamide N‑Methyltransferase (NNMT) with Enhanced Activity

Nicotinamide N-methyltransferase (NNMT) catalyzes the methylation of nicotinamide to form N-methylnicotinamide. Overexpression of NNMT is associated with a variety of diseases, including a number of cancers and metabolic disorders, suggesting a role for NNMT as a potential therapeutic target. By str...

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Veröffentlicht in:	Journal of medicinal chemistry 2019-07, Vol.62 (14), p.6597-6614
Hauptverfasser:	Gao, Yongzhi, van Haren, Matthijs J, Moret, Ed E, Rood, Johannes J. M, Sartini, Davide, Salvucci, Alessia, Emanuelli, Monica, Craveur, Pierrick, Babault, Nicolas, Jin, Jian, Martin, Nathaniel I
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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