Thirst regulates motivated behavior through modulation of brainwide neural population dynamics

Physiological needs produce motivational drives, such as thirst and hunger, that regulate behaviors essential to survival. Hypothalamic neurons sense these needs and must coordinate relevant brainwide neuronal activity to produce the appropriate behavior. We studied dynamics from ~24,000 neurons in...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2019-04, Vol.364 (6437), p.253-253
Hauptverfasser:	Allen, William E., Chen, Michael Z., Pichamoorthy, Nandini, Tien, Rebecca H., Pachitariu, Marius, Luo, Liqun, Deisseroth, Karl
Format:	Artikel
Sprache:	eng
Schlagworte:	Amygdala Animal behavior Animals Anxiety Arousal Behavior Brain Choice Behavior - physiology Coding Correlation Decision making Drinking water Dynamics Electrophysiological recording Exploratory behavior Feedback (Response) Female Flow mapping Hunger Hypothalamus Hypothalamus - cytology Hypothalamus - physiology Initial conditions Mice Mice, Inbred C57BL Motivation Motor activity Motor task performance Neural networks Neural Pathways - physiology Neurons Neurons - physiology Odor Odors Olfactory pathways Optogenetics Physiology Recording Representations RESEARCH ARTICLE SUMMARY Satiety Sensorimotor integration Sensory evaluation Sensory Receptor Cells - physiology Sensory stimulation Single-Cell Analysis Somatosensory cortex Stimuli Survival Technology Thirst Thirst - physiology Visual cortex Visual stimuli Water
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