Language boosting by transcranial stimulation in progressive supranuclear palsy
OBJECTIVETo explore whether transcranial direct current stimulation (tDCS) over the dorsolateral prefrontal cortex (DLPFC) can improve language capacities in patients with progressive supranuclear palsy (PSP). METHODSWe used a sham-controlled double-blind crossover design to assess the efficiency of...
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| Veröffentlicht in: | Neurology 2019-08, Vol.93 (6), p.e537-e547 |
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| creator | Valero-Cabré, Antoni Sanches, Clara Godard, Juliette Fracchia, Oriane Dubois, Bruno Levy, Richard Truong, Dennis Q Bikson, Marom Teichmann, Marc |
| description | OBJECTIVETo explore whether transcranial direct current stimulation (tDCS) over the dorsolateral prefrontal cortex (DLPFC) can improve language capacities in patients with progressive supranuclear palsy (PSP).
METHODSWe used a sham-controlled double-blind crossover design to assess the efficiency of tDCS over the DLPFC in a cohort of 12 patients with PSP. In 3 separate sessions, we evaluated the ability to boost the left DLPFC via left-anodal (excitatory) and right-cathodal (inhibitory) tDCS, while comparing them to sham tDCS. Tasks assessing lexical access (letter fluency task) and semantic access (category judgment task) were applied immediately before and after the tDCS sessions to provide a marker of potential language modulation.
RESULTSThe comparison with healthy controls showed that patients with PSP were impaired on both tasks at baseline. Contrasting poststimulation vs prestimulation performance across tDCS conditions revealed language improvement in the category judgment task following right-cathodal tDCS, and in the letter fluency task following left-anodal tDCS. A computational finite element model of current distribution corroborated the intended effect of left-anodal and right-cathodal tDCS on the targeted DLPFC.
CONCLUSIONSOur results demonstrate tDCS-driven language improvement in PSP. They provide proof-of-concept for the use of tDCS in PSP and set the stage for future multiday stimulation regimens, which might lead to longer-lasting therapeutic effects promoted by neuroplasticity.
CLASSIFICATION OF EVIDENCEThis study provides Class III evidence that for patients with PSP, tDCS over the DLPFC improves performance in some language tasks. |
| doi_str_mv | 10.1212/WNL.0000000000007893 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6709997</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2252261683</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5873-9d1e1748a7df41233184cd393dd7682e65f1ec4ce386b193ac06b1fdc62c84a83</originalsourceid><addsrcrecordid>eNqFkU9v1DAQxS0EotvCN0AoRzikeGzHfy5IVQUtUkQvILhZXsfJGrxxsJOt9tvj1Zaq9AA-eKSZ33v26CH0CvA5ECDvvn1uz_GDI6SiT9AKGsJrTsn3p2iFMZE1lUKeoNOcf2BchkI9RycUiMAExArdtGYcFjO4ah1jnv04VOt9NSczZlsub0JVutslmNnHsfJjNaU4JJez37kqL1OBFhucSdVkQt6_QM_6Ut3Lu3qGvn788OXyum5vrj5dXrS1baSgterAgWDSiK5nQCgFyWxHFe06wSVxvOnBWWYdlXwNihqLS-07y4mVzEh6ht4ffadlvXWddWP5c9BT8luT9joar_-ejH6jh7jTXGCllCgGb48Gm0ey64tWH3qYMGhA4R0U9s3dYyn-Wlye9dZn60Iwo4tL1oQ0hHDgkhaUHVGbYs7J9ffegPUhN11y049zK7LXD9e5F_0JqgDyCNzGMLuUf4bl1iW9cSbMm_95s39IDxgHYDXBZVmJOa4PrYb-Bm4ktaE</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2252261683</pqid></control><display><type>article</type><title>Language boosting by transcranial stimulation in progressive supranuclear palsy</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><source>Journals@Ovid Complete</source><creator>Valero-Cabré, Antoni ; Sanches, Clara ; Godard, Juliette ; Fracchia, Oriane ; Dubois, Bruno ; Levy, Richard ; Truong, Dennis Q ; Bikson, Marom ; Teichmann, Marc</creator><creatorcontrib>Valero-Cabré, Antoni ; Sanches, Clara ; Godard, Juliette ; Fracchia, Oriane ; Dubois, Bruno ; Levy, Richard ; Truong, Dennis Q ; Bikson, Marom ; Teichmann, Marc</creatorcontrib><description>OBJECTIVETo explore whether transcranial direct current stimulation (tDCS) over the dorsolateral prefrontal cortex (DLPFC) can improve language capacities in patients with progressive supranuclear palsy (PSP).
METHODSWe used a sham-controlled double-blind crossover design to assess the efficiency of tDCS over the DLPFC in a cohort of 12 patients with PSP. In 3 separate sessions, we evaluated the ability to boost the left DLPFC via left-anodal (excitatory) and right-cathodal (inhibitory) tDCS, while comparing them to sham tDCS. Tasks assessing lexical access (letter fluency task) and semantic access (category judgment task) were applied immediately before and after the tDCS sessions to provide a marker of potential language modulation.
RESULTSThe comparison with healthy controls showed that patients with PSP were impaired on both tasks at baseline. Contrasting poststimulation vs prestimulation performance across tDCS conditions revealed language improvement in the category judgment task following right-cathodal tDCS, and in the letter fluency task following left-anodal tDCS. A computational finite element model of current distribution corroborated the intended effect of left-anodal and right-cathodal tDCS on the targeted DLPFC.
CONCLUSIONSOur results demonstrate tDCS-driven language improvement in PSP. They provide proof-of-concept for the use of tDCS in PSP and set the stage for future multiday stimulation regimens, which might lead to longer-lasting therapeutic effects promoted by neuroplasticity.
CLASSIFICATION OF EVIDENCEThis study provides Class III evidence that for patients with PSP, tDCS over the DLPFC improves performance in some language tasks.</description><identifier>ISSN: 0028-3878</identifier><identifier>EISSN: 1526-632X</identifier><identifier>DOI: 10.1212/WNL.0000000000007893</identifier><identifier>PMID: 31270217</identifier><language>eng</language><publisher>United States: American Academy of Neurology</publisher><subject>Aged ; Cognitive science ; Cross-Over Studies ; Double-Blind Method ; Female ; Humans ; Judgment ; Language ; Male ; Middle Aged ; Neuropsychological Tests ; Neuroscience ; Prefrontal Cortex ; Psychomotor Performance ; Supranuclear Palsy, Progressive - psychology ; Supranuclear Palsy, Progressive - therapy ; Transcranial Direct Current Stimulation - methods ; Treatment Outcome</subject><ispartof>Neurology, 2019-08, Vol.93 (6), p.e537-e547</ispartof><rights>2019 American Academy of Neurology</rights><rights>2019 American Academy of Neurology.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><rights>2019 American Academy of Neurology 2019 American Academy of Neurology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5873-9d1e1748a7df41233184cd393dd7682e65f1ec4ce386b193ac06b1fdc62c84a83</citedby><cites>FETCH-LOGICAL-c5873-9d1e1748a7df41233184cd393dd7682e65f1ec4ce386b193ac06b1fdc62c84a83</cites><orcidid>0000-0002-5033-2279</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31270217$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-02415190$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Valero-Cabré, Antoni</creatorcontrib><creatorcontrib>Sanches, Clara</creatorcontrib><creatorcontrib>Godard, Juliette</creatorcontrib><creatorcontrib>Fracchia, Oriane</creatorcontrib><creatorcontrib>Dubois, Bruno</creatorcontrib><creatorcontrib>Levy, Richard</creatorcontrib><creatorcontrib>Truong, Dennis Q</creatorcontrib><creatorcontrib>Bikson, Marom</creatorcontrib><creatorcontrib>Teichmann, Marc</creatorcontrib><title>Language boosting by transcranial stimulation in progressive supranuclear palsy</title><title>Neurology</title><addtitle>Neurology</addtitle><description>OBJECTIVETo explore whether transcranial direct current stimulation (tDCS) over the dorsolateral prefrontal cortex (DLPFC) can improve language capacities in patients with progressive supranuclear palsy (PSP).
METHODSWe used a sham-controlled double-blind crossover design to assess the efficiency of tDCS over the DLPFC in a cohort of 12 patients with PSP. In 3 separate sessions, we evaluated the ability to boost the left DLPFC via left-anodal (excitatory) and right-cathodal (inhibitory) tDCS, while comparing them to sham tDCS. Tasks assessing lexical access (letter fluency task) and semantic access (category judgment task) were applied immediately before and after the tDCS sessions to provide a marker of potential language modulation.
RESULTSThe comparison with healthy controls showed that patients with PSP were impaired on both tasks at baseline. Contrasting poststimulation vs prestimulation performance across tDCS conditions revealed language improvement in the category judgment task following right-cathodal tDCS, and in the letter fluency task following left-anodal tDCS. A computational finite element model of current distribution corroborated the intended effect of left-anodal and right-cathodal tDCS on the targeted DLPFC.
CONCLUSIONSOur results demonstrate tDCS-driven language improvement in PSP. They provide proof-of-concept for the use of tDCS in PSP and set the stage for future multiday stimulation regimens, which might lead to longer-lasting therapeutic effects promoted by neuroplasticity.
CLASSIFICATION OF EVIDENCEThis study provides Class III evidence that for patients with PSP, tDCS over the DLPFC improves performance in some language tasks.</description><subject>Aged</subject><subject>Cognitive science</subject><subject>Cross-Over Studies</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Humans</subject><subject>Judgment</subject><subject>Language</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neuropsychological Tests</subject><subject>Neuroscience</subject><subject>Prefrontal Cortex</subject><subject>Psychomotor Performance</subject><subject>Supranuclear Palsy, Progressive - psychology</subject><subject>Supranuclear Palsy, Progressive - therapy</subject><subject>Transcranial Direct Current Stimulation - methods</subject><subject>Treatment Outcome</subject><issn>0028-3878</issn><issn>1526-632X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9v1DAQxS0EotvCN0AoRzikeGzHfy5IVQUtUkQvILhZXsfJGrxxsJOt9tvj1Zaq9AA-eKSZ33v26CH0CvA5ECDvvn1uz_GDI6SiT9AKGsJrTsn3p2iFMZE1lUKeoNOcf2BchkI9RycUiMAExArdtGYcFjO4ah1jnv04VOt9NSczZlsub0JVutslmNnHsfJjNaU4JJez37kqL1OBFhucSdVkQt6_QM_6Ut3Lu3qGvn788OXyum5vrj5dXrS1baSgterAgWDSiK5nQCgFyWxHFe06wSVxvOnBWWYdlXwNihqLS-07y4mVzEh6ht4ffadlvXWddWP5c9BT8luT9joar_-ejH6jh7jTXGCllCgGb48Gm0ey64tWH3qYMGhA4R0U9s3dYyn-Wlye9dZn60Iwo4tL1oQ0hHDgkhaUHVGbYs7J9ffegPUhN11y049zK7LXD9e5F_0JqgDyCNzGMLuUf4bl1iW9cSbMm_95s39IDxgHYDXBZVmJOa4PrYb-Bm4ktaE</recordid><startdate>20190806</startdate><enddate>20190806</enddate><creator>Valero-Cabré, Antoni</creator><creator>Sanches, Clara</creator><creator>Godard, Juliette</creator><creator>Fracchia, Oriane</creator><creator>Dubois, Bruno</creator><creator>Levy, Richard</creator><creator>Truong, Dennis Q</creator><creator>Bikson, Marom</creator><creator>Teichmann, Marc</creator><general>American Academy of Neurology</general><general>Lippincott Williams & Wilkins</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-5033-2279</orcidid></search><sort><creationdate>20190806</creationdate><title>Language boosting by transcranial stimulation in progressive supranuclear palsy</title><author>Valero-Cabré, Antoni ; Sanches, Clara ; Godard, Juliette ; Fracchia, Oriane ; Dubois, Bruno ; Levy, Richard ; Truong, Dennis Q ; Bikson, Marom ; Teichmann, Marc</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5873-9d1e1748a7df41233184cd393dd7682e65f1ec4ce386b193ac06b1fdc62c84a83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Aged</topic><topic>Cognitive science</topic><topic>Cross-Over Studies</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Humans</topic><topic>Judgment</topic><topic>Language</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neuropsychological Tests</topic><topic>Neuroscience</topic><topic>Prefrontal Cortex</topic><topic>Psychomotor Performance</topic><topic>Supranuclear Palsy, Progressive - psychology</topic><topic>Supranuclear Palsy, Progressive - therapy</topic><topic>Transcranial Direct Current Stimulation - methods</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Valero-Cabré, Antoni</creatorcontrib><creatorcontrib>Sanches, Clara</creatorcontrib><creatorcontrib>Godard, Juliette</creatorcontrib><creatorcontrib>Fracchia, Oriane</creatorcontrib><creatorcontrib>Dubois, Bruno</creatorcontrib><creatorcontrib>Levy, Richard</creatorcontrib><creatorcontrib>Truong, Dennis Q</creatorcontrib><creatorcontrib>Bikson, Marom</creatorcontrib><creatorcontrib>Teichmann, Marc</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Valero-Cabré, Antoni</au><au>Sanches, Clara</au><au>Godard, Juliette</au><au>Fracchia, Oriane</au><au>Dubois, Bruno</au><au>Levy, Richard</au><au>Truong, Dennis Q</au><au>Bikson, Marom</au><au>Teichmann, Marc</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Language boosting by transcranial stimulation in progressive supranuclear palsy</atitle><jtitle>Neurology</jtitle><addtitle>Neurology</addtitle><date>2019-08-06</date><risdate>2019</risdate><volume>93</volume><issue>6</issue><spage>e537</spage><epage>e547</epage><pages>e537-e547</pages><issn>0028-3878</issn><eissn>1526-632X</eissn><abstract>OBJECTIVETo explore whether transcranial direct current stimulation (tDCS) over the dorsolateral prefrontal cortex (DLPFC) can improve language capacities in patients with progressive supranuclear palsy (PSP).
METHODSWe used a sham-controlled double-blind crossover design to assess the efficiency of tDCS over the DLPFC in a cohort of 12 patients with PSP. In 3 separate sessions, we evaluated the ability to boost the left DLPFC via left-anodal (excitatory) and right-cathodal (inhibitory) tDCS, while comparing them to sham tDCS. Tasks assessing lexical access (letter fluency task) and semantic access (category judgment task) were applied immediately before and after the tDCS sessions to provide a marker of potential language modulation.
RESULTSThe comparison with healthy controls showed that patients with PSP were impaired on both tasks at baseline. Contrasting poststimulation vs prestimulation performance across tDCS conditions revealed language improvement in the category judgment task following right-cathodal tDCS, and in the letter fluency task following left-anodal tDCS. A computational finite element model of current distribution corroborated the intended effect of left-anodal and right-cathodal tDCS on the targeted DLPFC.
CONCLUSIONSOur results demonstrate tDCS-driven language improvement in PSP. They provide proof-of-concept for the use of tDCS in PSP and set the stage for future multiday stimulation regimens, which might lead to longer-lasting therapeutic effects promoted by neuroplasticity.
CLASSIFICATION OF EVIDENCEThis study provides Class III evidence that for patients with PSP, tDCS over the DLPFC improves performance in some language tasks.</abstract><cop>United States</cop><pub>American Academy of Neurology</pub><pmid>31270217</pmid><doi>10.1212/WNL.0000000000007893</doi><orcidid>https://orcid.org/0000-0002-5033-2279</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Neurology, 2019-08, Vol.93 (6), p.e537-e547 |
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| source | MEDLINE; Alma/SFX Local Collection; Journals@Ovid Complete |
| subjects | Aged Cognitive science Cross-Over Studies Double-Blind Method Female Humans Judgment Language Male Middle Aged Neuropsychological Tests Neuroscience Prefrontal Cortex Psychomotor Performance Supranuclear Palsy, Progressive - psychology Supranuclear Palsy, Progressive - therapy Transcranial Direct Current Stimulation - methods Treatment Outcome |
| title | Language boosting by transcranial stimulation in progressive supranuclear palsy |
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