Changing Trends in Etiology‐Based and Ethnicity‐Based Annual Mortality Rates of Cirrhosis and Hepatocellular Carcinoma in the United States
With recent improvements in the treatment of end‐stage liver disease (ESLD), a better understanding of the burden of cirrhosis and hepatocellular carcinoma (HCC) is needed in the United States. A population‐based study using the US Census and national mortality database was performed. We identified...
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| Veröffentlicht in: | Hepatology (Baltimore, Md.) Md.), 2019-03, Vol.69 (3), p.1064-1074 |
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| creator | Kim, Donghee Li, Andrew A. Perumpail, Brandon J. Gadiparthi, Chiranjeevi Kim, Won Cholankeril, George Glenn, Jeffrey S. Harrison, Stephen A. Younossi, Zobair M. Ahmed, Aijaz |
| description | With recent improvements in the treatment of end‐stage liver disease (ESLD), a better understanding of the burden of cirrhosis and hepatocellular carcinoma (HCC) is needed in the United States. A population‐based study using the US Census and national mortality database was performed. We identified the age‐standardized etiology‐specific mortality rates for cirrhosis and HCC among US adults ages 20 years or older from 2007 to 2016. We determined temporal mortality rate patterns by joinpoint analysis with estimates of annual percentage change (APC). Age‐standardized cirrhosis‐related mortality rates increased from 19.77/100,000 persons in 2007 to 23.67 in 2016 with an annual increase of 2.3% (95% confidence interval [CI] 2.0‐2.7). The APC in mortality rates for hepatitis C virus (HCV)‐cirrhosis shifted from a 2.9% increase per year during 2007 to 2014 to a 6.5% decline per year during 2014 to 2016. Meanwhile, mortality for cirrhosis from alcoholic liver disease (ALD, APC 4.5%) and NAFLD (APC 15.4%) increased over the same period, whereas mortality for hepatitis B virus (HBV)‐cirrhosis decreased with an average APC of −1.1%. HCC‐related mortality increased from 3.48/100,000 persons in 2007 to 4.41 in 2016 at an annual rate of 2.0% (95% CI 1.3‐2.6). Etiology‐specific mortality rates of HCC were largely consistent with cirrhosis‐related mortality. Minority populations had a higher burden of HCC‐related mortality. Conclusion: Cirrhosis‐related and HCC‐related mortality rates increased between 2007 and 2016 in the United States. However, mortality rates in HCV‐cirrhosis demonstrated a significant decline from 2014 to 2016, during the direct‐acting antiviral era. Mortality rates for ALD/NAFLD‐cirrhosis and HCC have continued to increase, whereas HBV‐cirrhosis‐related mortality declined during the 10‐year period. Importantly, minorities had a disproportionately higher burden of ESLD‐related mortality. |
| doi_str_mv | 10.1002/hep.30161 |
| format | Article |
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A population‐based study using the US Census and national mortality database was performed. We identified the age‐standardized etiology‐specific mortality rates for cirrhosis and HCC among US adults ages 20 years or older from 2007 to 2016. We determined temporal mortality rate patterns by joinpoint analysis with estimates of annual percentage change (APC). Age‐standardized cirrhosis‐related mortality rates increased from 19.77/100,000 persons in 2007 to 23.67 in 2016 with an annual increase of 2.3% (95% confidence interval [CI] 2.0‐2.7). The APC in mortality rates for hepatitis C virus (HCV)‐cirrhosis shifted from a 2.9% increase per year during 2007 to 2014 to a 6.5% decline per year during 2014 to 2016. Meanwhile, mortality for cirrhosis from alcoholic liver disease (ALD, APC 4.5%) and NAFLD (APC 15.4%) increased over the same period, whereas mortality for hepatitis B virus (HBV)‐cirrhosis decreased with an average APC of −1.1%. HCC‐related mortality increased from 3.48/100,000 persons in 2007 to 4.41 in 2016 at an annual rate of 2.0% (95% CI 1.3‐2.6). Etiology‐specific mortality rates of HCC were largely consistent with cirrhosis‐related mortality. Minority populations had a higher burden of HCC‐related mortality. Conclusion: Cirrhosis‐related and HCC‐related mortality rates increased between 2007 and 2016 in the United States. However, mortality rates in HCV‐cirrhosis demonstrated a significant decline from 2014 to 2016, during the direct‐acting antiviral era. Mortality rates for ALD/NAFLD‐cirrhosis and HCC have continued to increase, whereas HBV‐cirrhosis‐related mortality declined during the 10‐year period. Importantly, minorities had a disproportionately higher burden of ESLD‐related mortality.</description><identifier>ISSN: 0270-9139</identifier><identifier>EISSN: 1527-3350</identifier><identifier>DOI: 10.1002/hep.30161</identifier><identifier>PMID: 30014489</identifier><language>eng</language><publisher>United States: Wolters Kluwer Health, Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Carcinoma, Hepatocellular - etiology ; Carcinoma, Hepatocellular - mortality ; Cirrhosis ; Ethnic Groups ; Etiology ; Female ; Hepatitis ; Hepatitis B ; Hepatitis C ; Hepatocellular carcinoma ; Hepatology ; Humans ; Liver cancer ; Liver cirrhosis ; Liver Cirrhosis - etiology ; Liver Cirrhosis - mortality ; Liver diseases ; Liver Neoplasms - etiology ; Liver Neoplasms - mortality ; Male ; Middle Aged ; Minority & ethnic groups ; Mortality ; Population studies ; United States - epidemiology ; Young Adult</subject><ispartof>Hepatology (Baltimore, Md.), 2019-03, Vol.69 (3), p.1064-1074</ispartof><rights>2018 by the American Association for the Study of Liver Diseases.</rights><rights>2019 by the American Association for the Study of Liver Diseases.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5091-cbbe3c4655ff27a1b50ca7f85eeec5fc0aec74f3fe4fe768a1200ac910f00cd23</citedby><cites>FETCH-LOGICAL-c5091-cbbe3c4655ff27a1b50ca7f85eeec5fc0aec74f3fe4fe768a1200ac910f00cd23</cites><orcidid>0000-0002-3609-8586 ; 0000-0001-5335-8426 ; 0000-0003-1919-6800 ; 0000-0001-9313-577X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhep.30161$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhep.30161$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30014489$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Donghee</creatorcontrib><creatorcontrib>Li, Andrew A.</creatorcontrib><creatorcontrib>Perumpail, Brandon J.</creatorcontrib><creatorcontrib>Gadiparthi, Chiranjeevi</creatorcontrib><creatorcontrib>Kim, Won</creatorcontrib><creatorcontrib>Cholankeril, George</creatorcontrib><creatorcontrib>Glenn, Jeffrey S.</creatorcontrib><creatorcontrib>Harrison, Stephen A.</creatorcontrib><creatorcontrib>Younossi, Zobair M.</creatorcontrib><creatorcontrib>Ahmed, Aijaz</creatorcontrib><title>Changing Trends in Etiology‐Based and Ethnicity‐Based Annual Mortality Rates of Cirrhosis and Hepatocellular Carcinoma in the United States</title><title>Hepatology (Baltimore, Md.)</title><addtitle>Hepatology</addtitle><description>With recent improvements in the treatment of end‐stage liver disease (ESLD), a better understanding of the burden of cirrhosis and hepatocellular carcinoma (HCC) is needed in the United States. A population‐based study using the US Census and national mortality database was performed. We identified the age‐standardized etiology‐specific mortality rates for cirrhosis and HCC among US adults ages 20 years or older from 2007 to 2016. We determined temporal mortality rate patterns by joinpoint analysis with estimates of annual percentage change (APC). Age‐standardized cirrhosis‐related mortality rates increased from 19.77/100,000 persons in 2007 to 23.67 in 2016 with an annual increase of 2.3% (95% confidence interval [CI] 2.0‐2.7). The APC in mortality rates for hepatitis C virus (HCV)‐cirrhosis shifted from a 2.9% increase per year during 2007 to 2014 to a 6.5% decline per year during 2014 to 2016. Meanwhile, mortality for cirrhosis from alcoholic liver disease (ALD, APC 4.5%) and NAFLD (APC 15.4%) increased over the same period, whereas mortality for hepatitis B virus (HBV)‐cirrhosis decreased with an average APC of −1.1%. HCC‐related mortality increased from 3.48/100,000 persons in 2007 to 4.41 in 2016 at an annual rate of 2.0% (95% CI 1.3‐2.6). Etiology‐specific mortality rates of HCC were largely consistent with cirrhosis‐related mortality. Minority populations had a higher burden of HCC‐related mortality. Conclusion: Cirrhosis‐related and HCC‐related mortality rates increased between 2007 and 2016 in the United States. However, mortality rates in HCV‐cirrhosis demonstrated a significant decline from 2014 to 2016, during the direct‐acting antiviral era. Mortality rates for ALD/NAFLD‐cirrhosis and HCC have continued to increase, whereas HBV‐cirrhosis‐related mortality declined during the 10‐year period. 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Li, Andrew A. ; Perumpail, Brandon J. ; Gadiparthi, Chiranjeevi ; Kim, Won ; Cholankeril, George ; Glenn, Jeffrey S. ; Harrison, Stephen A. ; Younossi, Zobair M. ; Ahmed, Aijaz</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5091-cbbe3c4655ff27a1b50ca7f85eeec5fc0aec74f3fe4fe768a1200ac910f00cd23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Carcinoma, Hepatocellular - etiology</topic><topic>Carcinoma, Hepatocellular - mortality</topic><topic>Cirrhosis</topic><topic>Ethnic Groups</topic><topic>Etiology</topic><topic>Female</topic><topic>Hepatitis</topic><topic>Hepatitis B</topic><topic>Hepatitis C</topic><topic>Hepatocellular carcinoma</topic><topic>Hepatology</topic><topic>Humans</topic><topic>Liver cancer</topic><topic>Liver cirrhosis</topic><topic>Liver Cirrhosis - etiology</topic><topic>Liver Cirrhosis - mortality</topic><topic>Liver diseases</topic><topic>Liver Neoplasms - etiology</topic><topic>Liver Neoplasms - mortality</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Minority & ethnic groups</topic><topic>Mortality</topic><topic>Population studies</topic><topic>United States - epidemiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Donghee</creatorcontrib><creatorcontrib>Li, Andrew A.</creatorcontrib><creatorcontrib>Perumpail, Brandon J.</creatorcontrib><creatorcontrib>Gadiparthi, Chiranjeevi</creatorcontrib><creatorcontrib>Kim, Won</creatorcontrib><creatorcontrib>Cholankeril, George</creatorcontrib><creatorcontrib>Glenn, Jeffrey S.</creatorcontrib><creatorcontrib>Harrison, Stephen A.</creatorcontrib><creatorcontrib>Younossi, Zobair M.</creatorcontrib><creatorcontrib>Ahmed, Aijaz</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Hepatology (Baltimore, Md.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Donghee</au><au>Li, Andrew A.</au><au>Perumpail, Brandon J.</au><au>Gadiparthi, Chiranjeevi</au><au>Kim, Won</au><au>Cholankeril, George</au><au>Glenn, Jeffrey S.</au><au>Harrison, Stephen A.</au><au>Younossi, Zobair M.</au><au>Ahmed, Aijaz</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changing Trends in Etiology‐Based and Ethnicity‐Based Annual Mortality Rates of Cirrhosis and Hepatocellular Carcinoma in the United States</atitle><jtitle>Hepatology (Baltimore, Md.)</jtitle><addtitle>Hepatology</addtitle><date>2019-03</date><risdate>2019</risdate><volume>69</volume><issue>3</issue><spage>1064</spage><epage>1074</epage><pages>1064-1074</pages><issn>0270-9139</issn><eissn>1527-3350</eissn><abstract>With recent improvements in the treatment of end‐stage liver disease (ESLD), a better understanding of the burden of cirrhosis and hepatocellular carcinoma (HCC) is needed in the United States. A population‐based study using the US Census and national mortality database was performed. We identified the age‐standardized etiology‐specific mortality rates for cirrhosis and HCC among US adults ages 20 years or older from 2007 to 2016. We determined temporal mortality rate patterns by joinpoint analysis with estimates of annual percentage change (APC). Age‐standardized cirrhosis‐related mortality rates increased from 19.77/100,000 persons in 2007 to 23.67 in 2016 with an annual increase of 2.3% (95% confidence interval [CI] 2.0‐2.7). The APC in mortality rates for hepatitis C virus (HCV)‐cirrhosis shifted from a 2.9% increase per year during 2007 to 2014 to a 6.5% decline per year during 2014 to 2016. Meanwhile, mortality for cirrhosis from alcoholic liver disease (ALD, APC 4.5%) and NAFLD (APC 15.4%) increased over the same period, whereas mortality for hepatitis B virus (HBV)‐cirrhosis decreased with an average APC of −1.1%. HCC‐related mortality increased from 3.48/100,000 persons in 2007 to 4.41 in 2016 at an annual rate of 2.0% (95% CI 1.3‐2.6). Etiology‐specific mortality rates of HCC were largely consistent with cirrhosis‐related mortality. Minority populations had a higher burden of HCC‐related mortality. Conclusion: Cirrhosis‐related and HCC‐related mortality rates increased between 2007 and 2016 in the United States. However, mortality rates in HCV‐cirrhosis demonstrated a significant decline from 2014 to 2016, during the direct‐acting antiviral era. Mortality rates for ALD/NAFLD‐cirrhosis and HCC have continued to increase, whereas HBV‐cirrhosis‐related mortality declined during the 10‐year period. Importantly, minorities had a disproportionately higher burden of ESLD‐related mortality.</abstract><cop>United States</cop><pub>Wolters Kluwer Health, Inc</pub><pmid>30014489</pmid><doi>10.1002/hep.30161</doi><tpages>0</tpages><orcidid>https://orcid.org/0000-0002-3609-8586</orcidid><orcidid>https://orcid.org/0000-0001-5335-8426</orcidid><orcidid>https://orcid.org/0000-0003-1919-6800</orcidid><orcidid>https://orcid.org/0000-0001-9313-577X</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Carcinoma, Hepatocellular - etiology Carcinoma, Hepatocellular - mortality Cirrhosis Ethnic Groups Etiology Female Hepatitis Hepatitis B Hepatitis C Hepatocellular carcinoma Hepatology Humans Liver cancer Liver cirrhosis Liver Cirrhosis - etiology Liver Cirrhosis - mortality Liver diseases Liver Neoplasms - etiology Liver Neoplasms - mortality Male Middle Aged Minority & ethnic groups Mortality Population studies United States - epidemiology Young Adult |
| title | Changing Trends in Etiology‐Based and Ethnicity‐Based Annual Mortality Rates of Cirrhosis and Hepatocellular Carcinoma in the United States |
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