Structural basis for stereoselective dehydration and hydrogen-bonding catalysis by the SAM-dependent pericyclase LepI

LepI is an S- adenosylmethionine (SAM)-dependent pericyclase that catalyses the formation of the 2-pyridone natural product leporin C. Biochemical characterization has shown that LepI can catalyse stereoselective dehydration to yield a reactive ( E )-quinone methide that can undergo bifurcating intr...

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Veröffentlicht in:	Nature chemistry 2019-09, Vol.11 (9), p.812-820
Hauptverfasser:	Cai, Yujuan, Hai, Yang, Ohashi, Masao, Jamieson, Cooper S., Garcia-Borras, Marc, Houk, K. N., Zhou, Jiahai, Tang, Yi
Format:	Artikel
Sprache:	eng
Schlagworte:	631/45 631/535/1266 631/92/173 639/638/403/934 639/638/60 Adenosylmethionine Analytical Chemistry Bifurcations Biocatalysis Biochemistry Catalysis Chemistry Chemistry and Materials Science Chemistry/Food Science Crystal structure Crystallography, X-Ray Dehydration Hydrogen Bonding Inorganic Chemistry Methyltransferase Methyltransferases - chemistry Methyltransferases - metabolism Models, Molecular Molecular Structure Natural products Organic Chemistry Physical Chemistry Quinones S-Adenosylmethionine S-Adenosylmethionine - chemistry S-Adenosylmethionine - metabolism Stereoisomerism Stereoselectivity Substrates
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