HIV protease inhibitors block parasite signal peptide peptidases and prevent growth of Babesia microti parasites in erythrocytes

Malaria and babesiosis are bloodborne protozoan infections for which the emergence of drug-resistant strains poses a threat. Our previous phage display cDNA screens established the essentiality of Plasmodium falciparum signal peptide peptidase (SPP) in asexual development at the blood stage of malar...

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Veröffentlicht in:	Biochemical and biophysical research communications 2019-09, Vol.517 (1), p.125-131
Hauptverfasser:	Schwake, Christopher, Baldwin, Michael R., Bachovchin, William, Hegde, Shreeya, Schiemer, James, Okure, Carolyn, Levin, Andrew E., Vannier, Edouard, Hanada, Toshihiko, Chishti, Athar H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aspartic Acid Endopeptidases - antagonists & inhibitors Aspartic Acid Endopeptidases - metabolism Atazanavir Atazanavir Sulfate - pharmacology Atazanavir Sulfate - therapeutic use Babesia microti Babesia microti - drug effects Babesia microti - growth & development Babesia microti - metabolism babesiosis Babesiosis - drug therapy Babesiosis - parasitology bacteriophages drug resistance Erythrocyte erythrocytes Erythrocytes - parasitology HIV protease inhibitor HIV Protease Inhibitors - pharmacology HIV Protease Inhibitors - therapeutic use Humans Lopinavir Lopinavir - pharmacology Lopinavir - therapeutic use malaria Mice parasitemia Parasitemia - drug therapy Parasitemia - parasitology parasites Plasmodium falciparum proteinases Protozoa Protozoan Proteins - antagonists & inhibitors Protozoan Proteins - metabolism signal peptide Signal peptide peptidase (SPP) therapeutics
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