Autophagy Enhances Memory Erasure through Synaptic Destabilization

There is substantial interest in memory reconsolidation as a target for the treatment of anxiety disorders, such as post-traumatic stress disorder. However, its applicability is restricted by reconsolidation-resistant boundary conditions that constrain the initial memory destabilization. In this stu...

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Veröffentlicht in:	The Journal of neuroscience 2018-04, Vol.38 (15), p.3809-3822
Hauptverfasser:	Shehata, Mohammad, Abdou, Kareem, Choko, Kiriko, Matsuo, Mina, Nishizono, Hirofumi, Inokuchi, Kaoru
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Amygdala Amygdala - metabolism Amygdala - physiology Animals Anxiety Autophagy Biodegradation Boundary conditions Degradation Destabilization Endocytosis Fear Glutamic acid receptors Hippocampus - metabolism Hippocampus - physiology Long-term potentiation Male Memory Mental disorders Mice Mice, Inbred C57BL N-Methyl-D-aspartic acid receptors Phagocytosis Post traumatic stress disorder Proteins Proteolysis Rats Rats, Wistar Receptors, AMPA - metabolism Receptors, N-Methyl-D-Aspartate - metabolism Synaptic Transmission α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors
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