Promoting Sleep Oscillations and Their Functional Coupling by Transcranial Stimulation Enhances Memory Consolidation in Mild Cognitive Impairment
Alzheimer's disease (AD) not only involves loss of memory functions, but also prominent deterioration of sleep physiology, which is already evident at the stage of mild cognitive impairment (MCI). Cortical slow oscillations (SO; 0.5-1 Hz) and thalamocortical spindle activity (12-15 Hz) during s...
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creator | Ladenbauer, Julia Ladenbauer, Josef Külzow, Nadine de Boor, Rebecca Avramova, Elena Grittner, Ulrike Flöel, Agnes |
description | Alzheimer's disease (AD) not only involves loss of memory functions, but also prominent deterioration of sleep physiology, which is already evident at the stage of mild cognitive impairment (MCI). Cortical slow oscillations (SO; 0.5-1 Hz) and thalamocortical spindle activity (12-15 Hz) during sleep, and their temporal coordination, are considered critical for memory formation. We investigated the potential of slow oscillatory transcranial direct current stimulation (so-tDCS), applied during a daytime nap in a sleep-state-dependent manner, to modulate these activity patterns and sleep-related memory consolidation in nine male and seven female human patients with MCI. Stimulation significantly increased overall SO and spindle power, amplified spindle power during SO up-phases, and led to stronger synchronization between SO and spindle power fluctuations in EEG recordings. Moreover, visual declarative memory was improved by so-tDCS compared with sham stimulation and was associated with stronger synchronization. These findings indicate a well-tolerated therapeutic approach for disordered sleep physiology and memory deficits in MCI patients and advance our understanding of offline memory consolidation.
In the light of increasing evidence that sleep disruption is crucially involved in the progression of Alzheimer's disease (AD), sleep appears as a promising treatment target in this pathology, particularly to counteract memory decline. This study demonstrates the potential of a noninvasive brain stimulation method during sleep in patients with mild cognitive impairment (MCI), a precursor of AD, and advances our understanding of its mechanism. We provide first time evidence that slow oscillatory transcranial stimulation amplifies the functional cross-frequency coupling between memory-relevant brain oscillations and improves visual memory consolidation in patients with MCI. |
doi_str_mv | 10.1523/JNEUROSCI.0260-17.2017 |
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In the light of increasing evidence that sleep disruption is crucially involved in the progression of Alzheimer's disease (AD), sleep appears as a promising treatment target in this pathology, particularly to counteract memory decline. This study demonstrates the potential of a noninvasive brain stimulation method during sleep in patients with mild cognitive impairment (MCI), a precursor of AD, and advances our understanding of its mechanism. We provide first time evidence that slow oscillatory transcranial stimulation amplifies the functional cross-frequency coupling between memory-relevant brain oscillations and improves visual memory consolidation in patients with MCI.</description><identifier>ISSN: 0270-6474</identifier><identifier>EISSN: 1529-2401</identifier><identifier>DOI: 10.1523/JNEUROSCI.0260-17.2017</identifier><identifier>PMID: 28637840</identifier><language>eng</language><publisher>United States: Society for Neuroscience</publisher><subject>Activity patterns ; Aged ; Alzheimer's disease ; Animal memory ; Biological Clocks ; Brain Waves ; Cerebral cortex ; Cognitive ability ; Cognitive Dysfunction - complications ; Cognitive Dysfunction - physiopathology ; Cognitive Dysfunction - therapy ; Consolidation ; Direct current ; EEG ; Electrical stimulation of the brain ; ESB ; Female ; Humans ; Impairment ; Male ; Memory ; Memory Consolidation ; Memory Disorders - etiology ; Memory Disorders - physiopathology ; Memory Disorders - therapy ; Neurodegenerative diseases ; Oscillations ; Patients ; Physiology ; Sleep ; Stimulation ; Synchronism ; Synchronization ; Thalamus ; Transcranial Direct Current Stimulation - methods ; Treatment Outcome ; Variation</subject><ispartof>The Journal of neuroscience, 2017-07, Vol.37 (30), p.7111-7124</ispartof><rights>Copyright © 2017 the authors 0270-6474/17/377111-14$15.00/0.</rights><rights>Copyright Society for Neuroscience Jul 26, 2017</rights><rights>Copyright © 2017 the authors 0270-6474/17/377111-14$15.00/0 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c495t-c76a0119d2b1708164bf84d659c924a0e85e51d1ad45878f7298b75f83cd51373</citedby><orcidid>0000-0002-1475-5872 ; 0000-0002-1727-7431 ; 0000-0003-2595-0224 ; 0000-0001-5060-250X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6705731/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6705731/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28637840$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ladenbauer, Julia</creatorcontrib><creatorcontrib>Ladenbauer, Josef</creatorcontrib><creatorcontrib>Külzow, Nadine</creatorcontrib><creatorcontrib>de Boor, Rebecca</creatorcontrib><creatorcontrib>Avramova, Elena</creatorcontrib><creatorcontrib>Grittner, Ulrike</creatorcontrib><creatorcontrib>Flöel, Agnes</creatorcontrib><title>Promoting Sleep Oscillations and Their Functional Coupling by Transcranial Stimulation Enhances Memory Consolidation in Mild Cognitive Impairment</title><title>The Journal of neuroscience</title><addtitle>J Neurosci</addtitle><description>Alzheimer's disease (AD) not only involves loss of memory functions, but also prominent deterioration of sleep physiology, which is already evident at the stage of mild cognitive impairment (MCI). Cortical slow oscillations (SO; 0.5-1 Hz) and thalamocortical spindle activity (12-15 Hz) during sleep, and their temporal coordination, are considered critical for memory formation. We investigated the potential of slow oscillatory transcranial direct current stimulation (so-tDCS), applied during a daytime nap in a sleep-state-dependent manner, to modulate these activity patterns and sleep-related memory consolidation in nine male and seven female human patients with MCI. Stimulation significantly increased overall SO and spindle power, amplified spindle power during SO up-phases, and led to stronger synchronization between SO and spindle power fluctuations in EEG recordings. Moreover, visual declarative memory was improved by so-tDCS compared with sham stimulation and was associated with stronger synchronization. These findings indicate a well-tolerated therapeutic approach for disordered sleep physiology and memory deficits in MCI patients and advance our understanding of offline memory consolidation.
In the light of increasing evidence that sleep disruption is crucially involved in the progression of Alzheimer's disease (AD), sleep appears as a promising treatment target in this pathology, particularly to counteract memory decline. This study demonstrates the potential of a noninvasive brain stimulation method during sleep in patients with mild cognitive impairment (MCI), a precursor of AD, and advances our understanding of its mechanism. We provide first time evidence that slow oscillatory transcranial stimulation amplifies the functional cross-frequency coupling between memory-relevant brain oscillations and improves visual memory consolidation in patients with MCI.</description><subject>Activity patterns</subject><subject>Aged</subject><subject>Alzheimer's disease</subject><subject>Animal memory</subject><subject>Biological Clocks</subject><subject>Brain Waves</subject><subject>Cerebral cortex</subject><subject>Cognitive ability</subject><subject>Cognitive Dysfunction - complications</subject><subject>Cognitive Dysfunction - physiopathology</subject><subject>Cognitive Dysfunction - therapy</subject><subject>Consolidation</subject><subject>Direct current</subject><subject>EEG</subject><subject>Electrical stimulation of the brain</subject><subject>ESB</subject><subject>Female</subject><subject>Humans</subject><subject>Impairment</subject><subject>Male</subject><subject>Memory</subject><subject>Memory Consolidation</subject><subject>Memory Disorders - etiology</subject><subject>Memory Disorders - physiopathology</subject><subject>Memory Disorders - therapy</subject><subject>Neurodegenerative diseases</subject><subject>Oscillations</subject><subject>Patients</subject><subject>Physiology</subject><subject>Sleep</subject><subject>Stimulation</subject><subject>Synchronism</subject><subject>Synchronization</subject><subject>Thalamus</subject><subject>Transcranial Direct Current Stimulation - methods</subject><subject>Treatment Outcome</subject><subject>Variation</subject><issn>0270-6474</issn><issn>1529-2401</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdUd1q2zAUFmNlzbq9QhHsZjdOJVk_9s1ghLRLaZuxpNdCluVExZY8yS7kMfbGk0kX1t6cA-f70dH5ALjEaI4Zya9uH5aPv9abxWqOCEcZFnOCsHgHZgktM0IRfg9miAiUcSroOfgY4xNCSCTSB3BOCp6LgqIZ-PMz-M4P1u3gpjWmh-uobduqwXoXoXI13O6NDfB6dHqaqRYu_Ni3k6A6wG1QLupUbAI2g-3GoxQu3V45bSK8N50PhyRy0be2PqLWwXvb1mm6c3awzwauul7Z0Bk3fAJnjWqj-fzSL8Dj9XK7-JHdrW9Wi-93maYlGzItuEIYlzWpsEAF5rRqClpzVuqSUIVMwQzDNVY1ZYUoGkHKohKsKXJdM5yL_AJ8O_r2Y9WZWqeng2plH2ynwkF6ZeVrxNm93PlnyQViIsfJ4OuLQfC_RxMH2dmoTTqeM36MEpeY8LQhY4n65Q31yY8hHTNKgsqclpznE4sfWTr4GINpTstgJKfU5Sl1OaUusZBT6kl4-f9XTrJ_Med_AeSNrII</recordid><startdate>20170726</startdate><enddate>20170726</enddate><creator>Ladenbauer, Julia</creator><creator>Ladenbauer, Josef</creator><creator>Külzow, Nadine</creator><creator>de Boor, Rebecca</creator><creator>Avramova, Elena</creator><creator>Grittner, Ulrike</creator><creator>Flöel, Agnes</creator><general>Society for Neuroscience</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QR</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1475-5872</orcidid><orcidid>https://orcid.org/0000-0002-1727-7431</orcidid><orcidid>https://orcid.org/0000-0003-2595-0224</orcidid><orcidid>https://orcid.org/0000-0001-5060-250X</orcidid></search><sort><creationdate>20170726</creationdate><title>Promoting Sleep Oscillations and Their Functional Coupling by Transcranial Stimulation Enhances Memory Consolidation in Mild Cognitive Impairment</title><author>Ladenbauer, Julia ; Ladenbauer, Josef ; Külzow, Nadine ; de Boor, Rebecca ; Avramova, Elena ; Grittner, Ulrike ; Flöel, Agnes</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c495t-c76a0119d2b1708164bf84d659c924a0e85e51d1ad45878f7298b75f83cd51373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Activity patterns</topic><topic>Aged</topic><topic>Alzheimer's disease</topic><topic>Animal memory</topic><topic>Biological Clocks</topic><topic>Brain Waves</topic><topic>Cerebral cortex</topic><topic>Cognitive ability</topic><topic>Cognitive Dysfunction - complications</topic><topic>Cognitive Dysfunction - physiopathology</topic><topic>Cognitive Dysfunction - therapy</topic><topic>Consolidation</topic><topic>Direct current</topic><topic>EEG</topic><topic>Electrical stimulation of the brain</topic><topic>ESB</topic><topic>Female</topic><topic>Humans</topic><topic>Impairment</topic><topic>Male</topic><topic>Memory</topic><topic>Memory Consolidation</topic><topic>Memory Disorders - etiology</topic><topic>Memory Disorders - physiopathology</topic><topic>Memory Disorders - therapy</topic><topic>Neurodegenerative diseases</topic><topic>Oscillations</topic><topic>Patients</topic><topic>Physiology</topic><topic>Sleep</topic><topic>Stimulation</topic><topic>Synchronism</topic><topic>Synchronization</topic><topic>Thalamus</topic><topic>Transcranial Direct Current Stimulation - methods</topic><topic>Treatment Outcome</topic><topic>Variation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ladenbauer, Julia</creatorcontrib><creatorcontrib>Ladenbauer, Josef</creatorcontrib><creatorcontrib>Külzow, Nadine</creatorcontrib><creatorcontrib>de Boor, Rebecca</creatorcontrib><creatorcontrib>Avramova, Elena</creatorcontrib><creatorcontrib>Grittner, Ulrike</creatorcontrib><creatorcontrib>Flöel, Agnes</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ladenbauer, Julia</au><au>Ladenbauer, Josef</au><au>Külzow, Nadine</au><au>de Boor, Rebecca</au><au>Avramova, Elena</au><au>Grittner, Ulrike</au><au>Flöel, Agnes</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Promoting Sleep Oscillations and Their Functional Coupling by Transcranial Stimulation Enhances Memory Consolidation in Mild Cognitive Impairment</atitle><jtitle>The Journal of neuroscience</jtitle><addtitle>J Neurosci</addtitle><date>2017-07-26</date><risdate>2017</risdate><volume>37</volume><issue>30</issue><spage>7111</spage><epage>7124</epage><pages>7111-7124</pages><issn>0270-6474</issn><eissn>1529-2401</eissn><abstract>Alzheimer's disease (AD) not only involves loss of memory functions, but also prominent deterioration of sleep physiology, which is already evident at the stage of mild cognitive impairment (MCI). Cortical slow oscillations (SO; 0.5-1 Hz) and thalamocortical spindle activity (12-15 Hz) during sleep, and their temporal coordination, are considered critical for memory formation. We investigated the potential of slow oscillatory transcranial direct current stimulation (so-tDCS), applied during a daytime nap in a sleep-state-dependent manner, to modulate these activity patterns and sleep-related memory consolidation in nine male and seven female human patients with MCI. Stimulation significantly increased overall SO and spindle power, amplified spindle power during SO up-phases, and led to stronger synchronization between SO and spindle power fluctuations in EEG recordings. Moreover, visual declarative memory was improved by so-tDCS compared with sham stimulation and was associated with stronger synchronization. These findings indicate a well-tolerated therapeutic approach for disordered sleep physiology and memory deficits in MCI patients and advance our understanding of offline memory consolidation.
In the light of increasing evidence that sleep disruption is crucially involved in the progression of Alzheimer's disease (AD), sleep appears as a promising treatment target in this pathology, particularly to counteract memory decline. This study demonstrates the potential of a noninvasive brain stimulation method during sleep in patients with mild cognitive impairment (MCI), a precursor of AD, and advances our understanding of its mechanism. We provide first time evidence that slow oscillatory transcranial stimulation amplifies the functional cross-frequency coupling between memory-relevant brain oscillations and improves visual memory consolidation in patients with MCI.</abstract><cop>United States</cop><pub>Society for Neuroscience</pub><pmid>28637840</pmid><doi>10.1523/JNEUROSCI.0260-17.2017</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0002-1475-5872</orcidid><orcidid>https://orcid.org/0000-0002-1727-7431</orcidid><orcidid>https://orcid.org/0000-0003-2595-0224</orcidid><orcidid>https://orcid.org/0000-0001-5060-250X</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Activity patterns Aged Alzheimer's disease Animal memory Biological Clocks Brain Waves Cerebral cortex Cognitive ability Cognitive Dysfunction - complications Cognitive Dysfunction - physiopathology Cognitive Dysfunction - therapy Consolidation Direct current EEG Electrical stimulation of the brain ESB Female Humans Impairment Male Memory Memory Consolidation Memory Disorders - etiology Memory Disorders - physiopathology Memory Disorders - therapy Neurodegenerative diseases Oscillations Patients Physiology Sleep Stimulation Synchronism Synchronization Thalamus Transcranial Direct Current Stimulation - methods Treatment Outcome Variation |
title | Promoting Sleep Oscillations and Their Functional Coupling by Transcranial Stimulation Enhances Memory Consolidation in Mild Cognitive Impairment |
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