Adipokines Deregulate Cellular Communication via Epigenetic Repression of Gap Junction Loci in Obese Endometrial Cancer

Emerging evidence indicates that adipose stromal cells (ASC) are recruited to enhance cancer development. In this study, we examined the role these adipocyte progenitors play relating to intercellular communication in obesity-associated endometrial cancer. This is particularly relevant given that ga...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2019-01, Vol.79 (1), p.196-208
Hauptverfasser:	Polusani, Srikanth R, Huang, Yi-Wen, Huang, Guangcun, Chen, Chun-Wei, Wang, Chiou-Miin, Lin, Li-Ling, Osmulski, Pawel, Lucio, Nicholas D, Liu, Lu, Hsu, Ya-Ting, Zhou, Yufan, Lin, Chun-Lin, Aguilera-Barrantes, Irene, Valente, Philip T, Kost, Edward R, Chen, Chun-Liang, Shim, Eun Yong, Lee, Sang Eun, Ruan, Jianhua, Gaczynska, Maria E, Yan, Pearlly, Goodfellow, Paul J, Mutch, David G, Jin, Victor X, Nicholson, Bruce J, Huang, Tim H-M, Kirma, Nameer B
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipokines - pharmacology Adipose Tissue - metabolism Adipose Tissue - pathology Animals Cell Communication Cell Movement Cells, Cultured Connexin 43 - genetics Connexin 43 - metabolism Diet, High-Fat - adverse effects Endometrial Neoplasms - etiology Endometrial Neoplasms - metabolism Endometrial Neoplasms - pathology Epigenetic Repression Epithelial Cells - metabolism Epithelial Cells - pathology Female Gap Junctions Humans Mice Mice, Knockout Obesity - complications Obesity - physiopathology Stromal Cells - metabolism Stromal Cells - pathology
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