GluA2 trafficking is involved in apoptosis of retinal ganglion cells induced by activation of EphB/EphrinB reverse signaling in a rat chronic ocular hypertension model

EphB1, expressed in Müller cells, and ephrinB2, expressed in both Müller cells and retinal ganglion cells (RGCs), constitute an EphB/ephrinB reverse signaling in RGCs. Whether and how this reverse signaling is involved in RGC apoptosis in a rat chronic ocular hypertension (COH) model was investigate...

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Veröffentlicht in:	The Journal of neuroscience 2015-04, Vol.35 (13), p.5409-5421
Hauptverfasser:	Dong, Ling-Dan, Gao, Feng, Wang, Xiao-Han, Miao, Yanying, Wang, Shu-Yue, Wu, Yi, Li, Fang, Wu, Jihong, Cheng, Xiang-Lin, Sun, Xing-Huai, Yang, Xiong-Li, Wang, Zhongfeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Apoptosis - physiology Disease Models, Animal Ephrin-B2 - agonists Ephrin-B2 - metabolism Excitatory Postsynaptic Potentials In Situ Nick-End Labeling Male Ocular Hypertension - metabolism Phosphorylation Protein Transport - drug effects Pyrimidines - pharmacology Rats Receptor, EphB1 - metabolism Receptors, AMPA - antagonists & inhibitors Receptors, AMPA - metabolism Retinal Ganglion Cells - cytology Retinal Ganglion Cells - metabolism Retinal Ganglion Cells - physiology Signal Transduction src-Family Kinases - antagonists & inhibitors src-Family Kinases - metabolism
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