Secretin/secretin receptor signaling mediates biliary damage and liver fibrosis in early‐stage primary biliary cholangitis

ABSTRACTPrimary biliary cholangitis (PBC) primarily targets cholangiocytes and is characterized by liver fibrosis and biliary proliferation. Activation of the secretin (Sct)/secretin receptor (SR) axis, expressed only by cholangiocytes, increases biliary proliferation, liver fibrosis, and bicarbonat...

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Veröffentlicht in:	The FASEB journal 2019-09, Vol.33 (9), p.10269-10279
Hauptverfasser:	Kennedy, Lindsey, Francis, Heather, Invernizzi, Pietro, Venter, Julie, Wu, Nan, Carbone, Marco, Eric Gershwin, M., Bernuzzi, Francesca, Franchitto, Antonio, Alvaro, Domenico, Marzioni, Marco, Onori, Paolo, Gaudio, Eugenio, Sybenga, Amelia, Fabris, Luca, Meng, Fanyin, Glaser, Shannon, Alpini, Gianfranco
Format:	Artikel
Sprache:	eng
Schlagworte:	angiogenesis Animals Biliary Tract Diseases - etiology Biliary Tract Diseases - metabolism Biliary Tract Diseases - pathology Case-Control Studies cellular senescence cholangiopathies Female Humans Inflammation - etiology Inflammation - metabolism Inflammation - pathology Liver Cirrhosis - etiology Liver Cirrhosis - metabolism Liver Cirrhosis - pathology Liver Cirrhosis, Biliary - complications Liver Cirrhosis, Biliary - metabolism Liver Cirrhosis, Biliary - pathology liver damage Male Mice Mice, Inbred C57BL Mice, Knockout miR‐125b Receptor, Transforming Growth Factor-beta Type II - physiology Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism Receptors, Gastrointestinal Hormone - genetics Receptors, Gastrointestinal Hormone - metabolism Secretin - genetics Secretin - metabolism Signal Transduction Transforming Growth Factor beta1 - genetics Transforming Growth Factor beta1 - metabolism
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