MicroRNA-761 inhibits the metastasis of gastric cancer by negatively regulating Ras and Rab interactor 1
Gastric cancer (GC), the second most common malignant cancer worldwide, gives rise to a number of cancer-associated fatalities annually. Accumulating evidence has shown that microRNAs (miRs) may serve as oncogenes or tumor suppressors in GC development. The aim of this study was to discover the expr...
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| Veröffentlicht in: | Experimental and therapeutic medicine 2019-09, Vol.18 (3), p.3097-3103 |
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| creator | Zhang, Qifu Sui, Yana Sui, Xiaomei |
| description | Gastric cancer (GC), the second most common malignant cancer worldwide, gives rise to a number of cancer-associated fatalities annually. Accumulating evidence has shown that microRNAs (miRs) may serve as oncogenes or tumor suppressors in GC development. The aim of this study was to discover the expression, function and mechanism of miR-761 in GC progression. First, the findings revealed that the expression level of miR-761 was significantly decreased in GC cell lines and tissues. The functional studies showed that miR-761 in GC cells inhibited tumor proliferation and metastasis. In the mechanistic study, through an online database search and luciferase assay, Ras and Rab interactor 1 (RIN1), which has been demonstrated as an oncogene in various types of cancer, including GC, was identified as a target of miR-761. Notably, miR-761 expression was demonstrated to be negatively correlated with RIN1 mRNA levels in GC tissues. Simultaneously, overexpression of RIN1 partially rescued the inhibitory effect of miR-761 mimic in the GC cells. The present study provided new insights into the role of miR-761 in the progression of GC, and implicated the potential application of miR-761 in GC cell therapy. |
| doi_str_mv | 10.3892/ol.2019.10645 |
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Accumulating evidence has shown that microRNAs (miRs) may serve as oncogenes or tumor suppressors in GC development. The aim of this study was to discover the expression, function and mechanism of miR-761 in GC progression. First, the findings revealed that the expression level of miR-761 was significantly decreased in GC cell lines and tissues. The functional studies showed that miR-761 in GC cells inhibited tumor proliferation and metastasis. In the mechanistic study, through an online database search and luciferase assay, Ras and Rab interactor 1 (RIN1), which has been demonstrated as an oncogene in various types of cancer, including GC, was identified as a target of miR-761. Notably, miR-761 expression was demonstrated to be negatively correlated with RIN1 mRNA levels in GC tissues. Simultaneously, overexpression of RIN1 partially rescued the inhibitory effect of miR-761 mimic in the GC cells. The present study provided new insights into the role of miR-761 in the progression of GC, and implicated the potential application of miR-761 in GC cell therapy.</description><identifier>ISSN: 1792-1074</identifier><identifier>ISSN: 1792-0981</identifier><identifier>EISSN: 1792-1082</identifier><identifier>DOI: 10.3892/ol.2019.10645</identifier><identifier>PMID: 31452787</identifier><language>eng</language><publisher>Greece: Spandidos Publications</publisher><subject>Binding sites ; Bioinformatics ; Breast cancer ; Cancer ; Cancer metastasis ; Cancer treatment ; Cell adhesion & migration ; Cell growth ; Colorectal cancer ; Gastric cancer ; Gene expression ; Kidney cancer ; Liver cancer ; Luciferase ; Lung cancer ; Medical prognosis ; Messenger RNA ; Metastasis ; MicroRNA ; MicroRNAs ; Oncology ; Online databases ; Online searching ; RNA ; Scientific equipment industry ; Stomach cancer ; Studies ; Tumors</subject><ispartof>Experimental and therapeutic medicine, 2019-09, Vol.18 (3), p.3097-3103</ispartof><rights>COPYRIGHT 2019 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2019</rights><rights>Copyright: © Zhang et al. 2019</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c580t-ba8618ac0fafaa650d5b6c37fe6b197685c5cf161317ab4cda56e7d84004334e3</citedby><cites>FETCH-LOGICAL-c580t-ba8618ac0fafaa650d5b6c37fe6b197685c5cf161317ab4cda56e7d84004334e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6704297/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6704297/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31452787$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Qifu</creatorcontrib><creatorcontrib>Sui, Yana</creatorcontrib><creatorcontrib>Sui, Xiaomei</creatorcontrib><title>MicroRNA-761 inhibits the metastasis of gastric cancer by negatively regulating Ras and Rab interactor 1</title><title>Experimental and therapeutic medicine</title><addtitle>Oncol Lett</addtitle><description>Gastric cancer (GC), the second most common malignant cancer worldwide, gives rise to a number of cancer-associated fatalities annually. Accumulating evidence has shown that microRNAs (miRs) may serve as oncogenes or tumor suppressors in GC development. The aim of this study was to discover the expression, function and mechanism of miR-761 in GC progression. First, the findings revealed that the expression level of miR-761 was significantly decreased in GC cell lines and tissues. The functional studies showed that miR-761 in GC cells inhibited tumor proliferation and metastasis. In the mechanistic study, through an online database search and luciferase assay, Ras and Rab interactor 1 (RIN1), which has been demonstrated as an oncogene in various types of cancer, including GC, was identified as a target of miR-761. Notably, miR-761 expression was demonstrated to be negatively correlated with RIN1 mRNA levels in GC tissues. Simultaneously, overexpression of RIN1 partially rescued the inhibitory effect of miR-761 mimic in the GC cells. The present study provided new insights into the role of miR-761 in the progression of GC, and implicated the potential application of miR-761 in GC cell therapy.</description><subject>Binding sites</subject><subject>Bioinformatics</subject><subject>Breast cancer</subject><subject>Cancer</subject><subject>Cancer metastasis</subject><subject>Cancer treatment</subject><subject>Cell adhesion & migration</subject><subject>Cell growth</subject><subject>Colorectal cancer</subject><subject>Gastric cancer</subject><subject>Gene expression</subject><subject>Kidney cancer</subject><subject>Liver cancer</subject><subject>Luciferase</subject><subject>Lung cancer</subject><subject>Medical prognosis</subject><subject>Messenger RNA</subject><subject>Metastasis</subject><subject>MicroRNA</subject><subject>MicroRNAs</subject><subject>Oncology</subject><subject>Online databases</subject><subject>Online searching</subject><subject>RNA</subject><subject>Scientific equipment industry</subject><subject>Stomach cancer</subject><subject>Studies</subject><subject>Tumors</subject><issn>1792-1074</issn><issn>1792-0981</issn><issn>1792-1082</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqNkl1rFDEUhgdRbKm99FYCgngzazKZfMyNsBStQlUoeh0ymTMzKdmkJpnC_nuzbd12RdAkkJPkyXvy8VbVS4JXVHbNu-BWDSbdimDesifVMRFdUxMsm6f7WLRH1WlKV7gUxomU_Hl1REnLGiHFcTV_sSaGy6_rWnCCrJ9tb3NCeQa0gaxTaTahMKKpxNEaZLQ3EFG_RR4mne0NuC2KMC2uDPyELnVC2g-l74tchqhNDhGRF9WzUbsEp_f9SfXj44fvZ5_qi2_nn8_WF7VhEue617IcUhs86lFrzvDAem6oGIH3pBNcMsPMSDihROi-NYNmHMQgW4xbSlugJ9X7O93rpd_AYMDnqJ26jnaj41YFbdXhirezmsKN4gK3TSeKwNt7gRh-LpCy2thkwDntISxJNY0k5Yml7Ar6-g_0KizRl-sVqmNU8HLKB2rSDpT1Yyh5zU5UrTmmhNHyFf-gGoIZY7xQq79QpQ6wsSZ4GG2ZP5D9zw0PGd482jCDdnlOwS3ZBp8OwfoOLP5JKcK4f2OC1c6dKji1c6e6dWfhXz3-mD3924v0F3M228A</recordid><startdate>20190901</startdate><enddate>20190901</enddate><creator>Zhang, Qifu</creator><creator>Sui, Yana</creator><creator>Sui, Xiaomei</creator><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><general>D.A. Spandidos</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20190901</creationdate><title>MicroRNA-761 inhibits the metastasis of gastric cancer by negatively regulating Ras and Rab interactor 1</title><author>Zhang, Qifu ; Sui, Yana ; Sui, Xiaomei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c580t-ba8618ac0fafaa650d5b6c37fe6b197685c5cf161317ab4cda56e7d84004334e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Binding sites</topic><topic>Bioinformatics</topic><topic>Breast cancer</topic><topic>Cancer</topic><topic>Cancer metastasis</topic><topic>Cancer treatment</topic><topic>Cell adhesion & migration</topic><topic>Cell growth</topic><topic>Colorectal cancer</topic><topic>Gastric cancer</topic><topic>Gene expression</topic><topic>Kidney cancer</topic><topic>Liver cancer</topic><topic>Luciferase</topic><topic>Lung cancer</topic><topic>Medical prognosis</topic><topic>Messenger RNA</topic><topic>Metastasis</topic><topic>MicroRNA</topic><topic>MicroRNAs</topic><topic>Oncology</topic><topic>Online databases</topic><topic>Online searching</topic><topic>RNA</topic><topic>Scientific equipment industry</topic><topic>Stomach cancer</topic><topic>Studies</topic><topic>Tumors</topic><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Qifu</creatorcontrib><creatorcontrib>Sui, Yana</creatorcontrib><creatorcontrib>Sui, Xiaomei</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Experimental and therapeutic medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Qifu</au><au>Sui, Yana</au><au>Sui, Xiaomei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MicroRNA-761 inhibits the metastasis of gastric cancer by negatively regulating Ras and Rab interactor 1</atitle><jtitle>Experimental and therapeutic medicine</jtitle><addtitle>Oncol Lett</addtitle><date>2019-09-01</date><risdate>2019</risdate><volume>18</volume><issue>3</issue><spage>3097</spage><epage>3103</epage><pages>3097-3103</pages><issn>1792-1074</issn><issn>1792-0981</issn><eissn>1792-1082</eissn><abstract>Gastric cancer (GC), the second most common malignant cancer worldwide, gives rise to a number of cancer-associated fatalities annually. Accumulating evidence has shown that microRNAs (miRs) may serve as oncogenes or tumor suppressors in GC development. The aim of this study was to discover the expression, function and mechanism of miR-761 in GC progression. First, the findings revealed that the expression level of miR-761 was significantly decreased in GC cell lines and tissues. The functional studies showed that miR-761 in GC cells inhibited tumor proliferation and metastasis. In the mechanistic study, through an online database search and luciferase assay, Ras and Rab interactor 1 (RIN1), which has been demonstrated as an oncogene in various types of cancer, including GC, was identified as a target of miR-761. Notably, miR-761 expression was demonstrated to be negatively correlated with RIN1 mRNA levels in GC tissues. Simultaneously, overexpression of RIN1 partially rescued the inhibitory effect of miR-761 mimic in the GC cells. The present study provided new insights into the role of miR-761 in the progression of GC, and implicated the potential application of miR-761 in GC cell therapy.</abstract><cop>Greece</cop><pub>Spandidos Publications</pub><pmid>31452787</pmid><doi>10.3892/ol.2019.10645</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | Spandidos Publications Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Binding sites Bioinformatics Breast cancer Cancer Cancer metastasis Cancer treatment Cell adhesion & migration Cell growth Colorectal cancer Gastric cancer Gene expression Kidney cancer Liver cancer Luciferase Lung cancer Medical prognosis Messenger RNA Metastasis MicroRNA MicroRNAs Oncology Online databases Online searching RNA Scientific equipment industry Stomach cancer Studies Tumors |
| title | MicroRNA-761 inhibits the metastasis of gastric cancer by negatively regulating Ras and Rab interactor 1 |
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