Ectopic Expression Induces Abnormal Somatodendritic Distribution of Tau in the Mouse Brain

Tau is a microtubule (MT)-associated protein that is localized to the axon. In Alzheimer's disease, the distribution of tau undergoes a remarkable alteration, leading to the formation of tau inclusions in the somatodendritic compartment. To investigate how this mislocalization occurs, we recent...

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Veröffentlicht in:	The Journal of neuroscience 2019-08, Vol.39 (34), p.6781-6797
Hauptverfasser:	Kubo, Atsuko, Ueda, Shouyou, Yamane, Ayaka, Wada-Kakuda, Satoko, Narita, Mai, Matsuyama, Makoto, Nomori, Akane, Takashima, Akihiko, Kato, Taisuke, Onodera, Osamu, Goto, Motohito, Ito, Mamoru, Tomiyama, Takami, Mori, Hiroshi, Murayama, Shigeo, Ihara, Yasuo, Misonou, Hiroaki, Miyasaka, Tomohiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Antibodies Brain Dendrites Ectopic expression Inclusions Localization Mice Neonates Neurodegenerative diseases Rodents Tau protein Transgenic animals Transgenic mice
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