The Pancreatic Cancer-Initiating Cell Marker CD44v6 Affects Transcription, Translation, and Signaling: Consequences for Exosome Composition and Delivery

Pancreatic cancer-initiating cells (PaCIC) express CD44v6 and Tspan8. A knockdown (kd) of these markers hinders the metastatic capacity, which can be rescued, if the cells are exposed to CIC-exosomes (TEX). Additional evidence that CD44v6 regulates Tspan8 expression prompted us to explore the impact...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of oncology 2019, Vol.2019 (2019), p.1-24
Hauptverfasser:	Zöller, Margot, Lv, Qingjie, Provaznik, Jan, Schnölzer, Martina, Zhao, Kun, Wang, Zhe, Rana, Sanyukta, Sun, Hanxue, Hackert, Thilo
Format:	Artikel
Sprache:	eng
Schlagworte:	Biosynthesis Cancer Chromatography Development and progression Genetic transcription Kinases Mass spectrometry Metastasis MicroRNA Pancreatic cancer Particle size Peptides Proteins Scientific imaging Sucrose Wang Zhe
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!