Hybrid Insulin Peptides Are Autoantigens in Type 1 Diabetes

We recently established that hybrid insulin peptides (HIPs) are present in human islets and that T cells reactive to HIPs are found in the residual islets of organ donors with type 1 diabetes (T1D). Here, we investigate whether HIP-reactive T cells are indicative of ongoing autoimmunity in patients...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2019-09, Vol.68 (9), p.1830-1840
Hauptverfasser:	Baker, Rocky L, Rihanek, Marynette, Hohenstein, Anita C, Nakayama, Maki, Michels, Aaron, Gottlieb, Peter A, Haskins, Kathryn, Delong, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Autoantigens Autoantigens - immunology Autoimmunity Autoimmunity - immunology Blood & organ donations Child Diabetes Diabetes mellitus Diabetes mellitus (insulin dependent) Diabetes Mellitus, Type 1 - immunology Female Humans Immunology and Transplantation Insulin Insulin - immunology Islets of Langerhans - immunology Leukocytes (mononuclear) Leukocytes, Mononuclear - immunology Lymphocytes Lymphocytes T Male Organ donors Peptides Peripheral blood mononuclear cells T-Lymphocytes - immunology Young Adult γ-Interferon
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