Serial Synapse Formation through Filopodial Competition for Synaptic Seeding Factors

Following axon pathfinding, growth cones transition from stochastic filopodial exploration to the formation of a limited number of synapses. How the interplay of filopodia and synapse assembly ensures robust connectivity in the brain has remained a challenging problem. Here, we developed a new 4D an...

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Veröffentlicht in:	Developmental cell 2019-08, Vol.50 (4), p.447-461.e8
Hauptverfasser:	Özel, M. Neset, Kulkarni, Abhishek, Hasan, Amr, Brummer, Josephine, Moldenhauer, Marian, Daumann, Ilsa-Maria, Wolfenberg, Heike, Dercksen, Vincent J., Kiral, F. Ridvan, Weiser, Martin, Prohaska, Steffen, von Kleist, Max, Hiesinger, P. Robin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals axon Axons - metabolism Axons - ultrastructure brain Computer Simulation Development Drosophila Drosophila melanogaster - genetics Drosophila melanogaster - growth & development Drosophila Proteins - genetics filopodia Gene Expression Regulation, Developmental - genetics Growth Cones - metabolism Growth Cones - ultrastructure GTPase-Activating Proteins - genetics Intracellular Signaling Peptides and Proteins - genetics live imaging modeling Neurogenesis - genetics Phosphoproteins - genetics Pseudopodia - genetics Pseudopodia - physiology Pseudopodia - ultrastructure synapse formation Synapses - genetics Synapses - physiology Synapses - ultrastructure
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