FXR Regulates Intestinal Cancer Stem Cell Proliferation

Increased levels of intestinal bile acids (BAs) are a risk factor for colorectal cancer (CRC). Here, we show that the convergence of dietary factors (high-fat diet) and dysregulated WNT signaling (APC mutation) alters BA profiles to drive malignant transformations in Lgr5-expressing (Lgr5+) cancer s...

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Veröffentlicht in:	Cell 2019-02, Vol.176 (5), p.1098-1112.e18
Hauptverfasser:	Fu, Ting, Coulter, Sally, Yoshihara, Eiji, Oh, Tae Gyu, Fang, Sungsoon, Cayabyab, Fritz, Zhu, Qiyun, Zhang, Tong, Leblanc, Mathias, Liu, Sihao, He, Mingxiao, Waizenegger, Wanda, Gasser, Emanuel, Schnabl, Bernd, Atkins, Annette R., Yu, Ruth T., Knight, Rob, Liddle, Christopher, Downes, Michael, Evans, Ronald M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals BA-FXR axis Bile Acids and Salts - metabolism cell growth Cell Line cell proliferation Cell Proliferation - genetics colon cancer progression colorectal neoplasms Colorectal Neoplasms - metabolism deoxycholic acid Deoxycholic Acid - metabolism DNA damage Gene Expression Regulation, Neoplastic - genetics genetic and dietary risk factors high fat diet Humans Intestinal Neoplasms - genetics Intestinal Neoplasms - metabolism Intestines Lgr5+ intestinal stem cells Liver Mice Mice, Inbred C57BL mutation Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - physiology Organoids - metabolism Receptors, Cytoplasmic and Nuclear - genetics Receptors, Cytoplasmic and Nuclear - metabolism Risk Factors Signal Transduction stem cells Taurocholic Acid - analogs & derivatives Taurocholic Acid - metabolism therapeutics Wnt Signaling Pathway - genetics Wnt Signaling Pathway - physiology
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