Major imbalance of thyroid function after laparoscopic sleeve gastrectomy
In patients with substituted hypothyroidism, laparoscopic sleeve gastrectomy may interfere with thyroid balance by varying body weight or by altering the absorption of hormone therapy. A 58-year-old female patient presented with a major thyroid imbalance after sleeve gastrectomy, manifesting itself...
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Veröffentlicht in: | BMJ case reports 2019-08, Vol.12 (8), p.e230515 |
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description | In patients with substituted hypothyroidism, laparoscopic sleeve gastrectomy may interfere with thyroid balance by varying body weight or by altering the absorption of hormone therapy. A 58-year-old female patient presented with a major thyroid imbalance after sleeve gastrectomy, manifesting itself in large-scale changes in thyroid stimulating hormone (TSH) levels. The transition from a tablet treatment to a liquid form alleviated burden of treatment, unfortunately without normalising TSH. Our case emphasises the importance of the understanding of hypothalamic–pituitary–thyroid feedback control mechanisms together with good galenic choice, management of associated conditions and the elimination of other causes of variations of TSH levels during the management of hypothyroid patients after sleeve gastrectomy. |
doi_str_mv | 10.1136/bcr-2019-230515 |
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A 58-year-old female patient presented with a major thyroid imbalance after sleeve gastrectomy, manifesting itself in large-scale changes in thyroid stimulating hormone (TSH) levels. The transition from a tablet treatment to a liquid form alleviated burden of treatment, unfortunately without normalising TSH. Our case emphasises the importance of the understanding of hypothalamic–pituitary–thyroid feedback control mechanisms together with good galenic choice, management of associated conditions and the elimination of other causes of variations of TSH levels during the management of hypothyroid patients after sleeve gastrectomy.</description><identifier>ISSN: 1757-790X</identifier><identifier>EISSN: 1757-790X</identifier><identifier>DOI: 10.1136/bcr-2019-230515</identifier><identifier>PMID: 31401581</identifier><language>eng</language><publisher>England: BMJ Publishing Group LTD</publisher><subject>Case reports ; Dose-Response Relationship, Drug ; Drug dosages ; Female ; Gastrectomy - adverse effects ; Gastric Bypass - adverse effects ; Gastrointestinal surgery ; Hormone replacement therapy ; Hormone Replacement Therapy - methods ; Humans ; Hypothyroidism ; Hypothyroidism - blood ; Hypothyroidism - drug therapy ; Laparoscopy ; Middle Aged ; Multiple sclerosis ; Obesity ; Obesity, Morbid - surgery ; Patients ; Stomach ; Thyroid gland ; Thyrotropin - blood ; Thyroxine - administration & dosage ; Thyroxine - blood ; Unusual Association of Diseases/Symptoms ; Weight control</subject><ispartof>BMJ case reports, 2019-08, Vol.12 (8), p.e230515</ispartof><rights>BMJ Publishing Group Limited 2019. No commercial re-use. See rights and permissions. Published by BMJ.</rights><rights>2019 BMJ Publishing Group Limited 2019. No commercial re-use. See rights and permissions. Published by BMJ.</rights><rights>BMJ Publishing Group Limited 2019. No commercial re-use. See rights and permissions. Published by BMJ. 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-b410t-fb3ee4504cf4b7e4814c2d9566619a7cd90f4add2f934106b5a3ef4dd4749573</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700571/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700571/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31401581$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Brutus, Laurent</creatorcontrib><creatorcontrib>Poupard, Armelle</creatorcontrib><creatorcontrib>Le Glatin, Clément</creatorcontrib><title>Major imbalance of thyroid function after laparoscopic sleeve gastrectomy</title><title>BMJ case reports</title><addtitle>BMJ Case Rep</addtitle><description>In patients with substituted hypothyroidism, laparoscopic sleeve gastrectomy may interfere with thyroid balance by varying body weight or by altering the absorption of hormone therapy. A 58-year-old female patient presented with a major thyroid imbalance after sleeve gastrectomy, manifesting itself in large-scale changes in thyroid stimulating hormone (TSH) levels. The transition from a tablet treatment to a liquid form alleviated burden of treatment, unfortunately without normalising TSH. Our case emphasises the importance of the understanding of hypothalamic–pituitary–thyroid feedback control mechanisms together with good galenic choice, management of associated conditions and the elimination of other causes of variations of TSH levels during the management of hypothyroid patients after sleeve gastrectomy.</description><subject>Case reports</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug dosages</subject><subject>Female</subject><subject>Gastrectomy - adverse effects</subject><subject>Gastric Bypass - adverse effects</subject><subject>Gastrointestinal surgery</subject><subject>Hormone replacement therapy</subject><subject>Hormone Replacement Therapy - methods</subject><subject>Humans</subject><subject>Hypothyroidism</subject><subject>Hypothyroidism - blood</subject><subject>Hypothyroidism - drug therapy</subject><subject>Laparoscopy</subject><subject>Middle Aged</subject><subject>Multiple sclerosis</subject><subject>Obesity</subject><subject>Obesity, Morbid - surgery</subject><subject>Patients</subject><subject>Stomach</subject><subject>Thyroid gland</subject><subject>Thyrotropin - blood</subject><subject>Thyroxine - administration & dosage</subject><subject>Thyroxine - blood</subject><subject>Unusual Association of Diseases/Symptoms</subject><subject>Weight control</subject><issn>1757-790X</issn><issn>1757-790X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkM9rwyAUx2VsrKXrebch7DbIqonG5DIYZT8KHbv0sJuo0TYhiZmmhf73s6Qr3WlefODnfd_zA8AtRo8YJ-lMKhfFCOdRnCCK6QUYY0ZZxHL0dXlWj8DU-wqFk2CSkeQajEKBMM3wGCw-RGUdLBspatEqDa2B_WbvbFlAs21VX9oWCtNrB2vRCWe9sl2poK-13mm4Fr53WvW22d-AKyNqr6fHewJWry-r-Xu0_HxbzJ-XkSQY9ZGRidaEIqIMkUyTDBMVFzlN0xTngqkiR4aIoohNnoSGVFKRaEOKgjCSU5ZMwNMQ221lowul296JmneubITbcytK_velLTd8bXc8ZQhRhkPA_THA2e-t9j2v7Na1YWUex1nGCCEoC9RsoFT4snfanCZgxA_2ebDPD_b5YD903J0vduJ_XQfgYQBkU_2b9gMAQI7R</recordid><startdate>20190801</startdate><enddate>20190801</enddate><creator>Brutus, Laurent</creator><creator>Poupard, Armelle</creator><creator>Le Glatin, Clément</creator><general>BMJ Publishing Group LTD</general><general>BMJ Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope></search><sort><creationdate>20190801</creationdate><title>Major imbalance of thyroid function after laparoscopic sleeve gastrectomy</title><author>Brutus, Laurent ; Poupard, Armelle ; Le Glatin, Clément</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b410t-fb3ee4504cf4b7e4814c2d9566619a7cd90f4add2f934106b5a3ef4dd4749573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Case reports</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug dosages</topic><topic>Female</topic><topic>Gastrectomy - adverse effects</topic><topic>Gastric Bypass - adverse effects</topic><topic>Gastrointestinal surgery</topic><topic>Hormone replacement therapy</topic><topic>Hormone Replacement Therapy - methods</topic><topic>Humans</topic><topic>Hypothyroidism</topic><topic>Hypothyroidism - blood</topic><topic>Hypothyroidism - drug therapy</topic><topic>Laparoscopy</topic><topic>Middle Aged</topic><topic>Multiple sclerosis</topic><topic>Obesity</topic><topic>Obesity, Morbid - surgery</topic><topic>Patients</topic><topic>Stomach</topic><topic>Thyroid gland</topic><topic>Thyrotropin - blood</topic><topic>Thyroxine - administration & dosage</topic><topic>Thyroxine - blood</topic><topic>Unusual Association of Diseases/Symptoms</topic><topic>Weight control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brutus, Laurent</creatorcontrib><creatorcontrib>Poupard, Armelle</creatorcontrib><creatorcontrib>Le Glatin, Clément</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMJ case reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brutus, Laurent</au><au>Poupard, Armelle</au><au>Le Glatin, Clément</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Major imbalance of thyroid function after laparoscopic sleeve gastrectomy</atitle><jtitle>BMJ case reports</jtitle><addtitle>BMJ Case Rep</addtitle><date>2019-08-01</date><risdate>2019</risdate><volume>12</volume><issue>8</issue><spage>e230515</spage><pages>e230515-</pages><issn>1757-790X</issn><eissn>1757-790X</eissn><abstract>In patients with substituted hypothyroidism, laparoscopic sleeve gastrectomy may interfere with thyroid balance by varying body weight or by altering the absorption of hormone therapy. A 58-year-old female patient presented with a major thyroid imbalance after sleeve gastrectomy, manifesting itself in large-scale changes in thyroid stimulating hormone (TSH) levels. The transition from a tablet treatment to a liquid form alleviated burden of treatment, unfortunately without normalising TSH. Our case emphasises the importance of the understanding of hypothalamic–pituitary–thyroid feedback control mechanisms together with good galenic choice, management of associated conditions and the elimination of other causes of variations of TSH levels during the management of hypothyroid patients after sleeve gastrectomy.</abstract><cop>England</cop><pub>BMJ Publishing Group LTD</pub><pmid>31401581</pmid><doi>10.1136/bcr-2019-230515</doi><oa>free_for_read</oa></addata></record> |
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subjects | Case reports Dose-Response Relationship, Drug Drug dosages Female Gastrectomy - adverse effects Gastric Bypass - adverse effects Gastrointestinal surgery Hormone replacement therapy Hormone Replacement Therapy - methods Humans Hypothyroidism Hypothyroidism - blood Hypothyroidism - drug therapy Laparoscopy Middle Aged Multiple sclerosis Obesity Obesity, Morbid - surgery Patients Stomach Thyroid gland Thyrotropin - blood Thyroxine - administration & dosage Thyroxine - blood Unusual Association of Diseases/Symptoms Weight control |
title | Major imbalance of thyroid function after laparoscopic sleeve gastrectomy |
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