Mitochondrial 2,4-dienoyl-CoA reductase (Decr) deficiency and impairment of thermogenesis in mouse brown adipose tissue

A large number of studies have demonstrated significance of polyunsaturated fatty acids (PUFAs) for human health. However, many aspects on signals translating PUFA-sensing into body homeostasis have remained enigmatic. To shed light on PUFA physiology, we have generated a mouse line defective in mit...

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Veröffentlicht in:	Scientific reports 2019-08, Vol.9 (1), p.12038-16, Article 12038
Hauptverfasser:	Mäkelä, Anne M., Hohtola, Esa, Miinalainen, Ilkka J., Autio, Joonas A., Schmitz, Werner, Niemi, Kalle J., Hiltunen, J. Kalervo, Autio, Kaija J.
Format:	Artikel
Sprache:	eng
Schlagworte:	38/39 59/57 631/443/319/2723 631/443/319/333/1465 64/110 64/60 82/1 Adipose tissue Adipose tissue (brown) Adipose Tissue, Brown - metabolism Adipose Tissue, White - metabolism Animals Biochemical analysis Calorimetry Electron microscopy Fatty acids Fatty Acids - metabolism Gene Expression Homeostasis Humanities and Social Sciences Humans Hypoglycemia Hypothermia Intolerance Lipolysis Magnetic resonance imaging Mass spectrometry Mass spectroscopy Metabolic Networks and Pathways Metabolites Mice Mice, Knockout Mitochondria Mitochondria - genetics Mitochondria - metabolism multidisciplinary Oxidation Oxidation-Reduction Oxidoreductases Acting on CH-CH Group Donors - deficiency Polyunsaturated fatty acids Reductase Science Science (multidisciplinary) Stress, Physiological Thermogenesis Thermogenesis - genetics Thermography
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