Phosphatidylinositol 4,5-bisphosphate (PIP2) and Ca2+ are both required to open the Cl− channel TMEM16A

Transmembrane member 16A (TMEM16A) is a widely expressed Ca2+-activated Cl− channel with various physiological functions ranging from mucosal secretion to regulating smooth muscle contraction. Understanding how TMEM16A controls these physiological processes and how its dysregulation may cause diseas...

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Veröffentlicht in:	The Journal of biological chemistry 2019-08, Vol.294 (33), p.12556-12564
Hauptverfasser:	Tembo, Maiwase, Wozniak, Katherine L., Bainbridge, Rachel E., Carlson, Anne E.
Format:	Artikel
Sprache:	eng
Schlagworte:	anion channel calcium chloride channel Membrane Biology oocyte patch clamp phospholipid signal transduction transmembrane member 16A (TMEM16A) Xenopus
Online-Zugang:	Volltext
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