Phosphorylation and functionality of CdtR in Clostridium difficile

The production of TcdA, TcdB and CDT in Clostridium difficile PCR ribotype 027, is regulated by the two-component system response regulator CdtR. Despite this, little is known about the signal transduction pathway leading to the activation of CdtR. In this study, we generated R20291ΔPalocΔcdtR model...

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Veröffentlicht in:	Anaerobe 2019-08, Vol.58, p.103-109
Hauptverfasser:	Bilverstone, T.W., Minton, N.P., Kuehne, S.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Toxins - biosynthesis Binary toxin C. difficile CDT CdtR Clostridioides difficile - genetics Clostridioides difficile - metabolism Clostridium Infections Gene Expression Regulation, Bacterial Mutant Proteins - genetics Mutant Proteins - metabolism Phosphorylation Protein Processing, Post-Translational Sequence Deletion Signal Transduction Transcription Factors - genetics Transcription Factors - metabolism Two-component system Virulence
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