Structural and functional studies of USP20 ZnF‐UBP domain by NMR

Deubiquitinase USP20/VDU2 has been demonstrated to play important roles in multiple cellular processes by controlling the life span of substrate proteins including hypoxia‐inducible factor HIF1α, and so forth. USP20 contains four distinct structural domains including the N‐terminal zinc‐finger ubiqu...

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Veröffentlicht in:	Protein science 2019-09, Vol.28 (9), p.1606-1619
Hauptverfasser:	Yang, Yuanyuan, Ding, Yiluan, Zhou, Chen, Wen, Yi, Zhang, Naixia
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Binding Catalysis Catalytic Domain deubiquitinase Docking Domains Electrostatic properties Full‐Length Papers Glycine Helices Humans Hypoxia Magnetic Resonance Spectroscopy Models, Molecular Molecular Docking Simulation Molecular modelling NMR Nuclear magnetic resonance Protein Binding Protein Structure, Secondary solution structure Structure-function relationships Substrates Ubiquitin Ubiquitin - metabolism Ubiquitin Thiolesterase - chemistry Ubiquitin Thiolesterase - genetics Ubiquitin Thiolesterase - metabolism USP20 Zinc finger proteins Zinc Fingers ZnF‐UBP domain
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