Neuroimmune and epigenetic involvement in adolescent binge ethanol‐induced loss of basal forebrain cholinergic neurons: Restoration with voluntary exercise

Binge drinking and alcohol abuse are common during adolescence and cause lasting pathology. Preclinical rodent studies using the adolescent intermittent ethanol (AIE; 5.0 g/kg, i.g., 2‐day on/2‐day off from postnatal day [P]25 to P55) model of human adolescent binge drinking report decreased basal f...

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Veröffentlicht in:	Addiction biology 2020-03, Vol.25 (2), p.e12731-n/a
Hauptverfasser:	Vetreno, Ryan P., Bohnsack, John Peyton, Kusumo, Handojo, Liu, Wen, Pandey, Subhash C., Crews, Fulton T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Abuse adolescence alcohol Animals Basal forebrain Basal Forebrain - drug effects Basal Forebrain - physiopathology binge drinking Binge Drinking - genetics Binge Drinking - physiopathology choline acetyltransferase Cholinergic nerves Cholinergic Neurons - drug effects Cognitive ability Deoxyribonucleic acid Disease Models, Animal DNA DNA methylation Drinking behavior Drug abuse Epigenesis, Genetic - drug effects Epigenesis, Genetic - genetics Epigenetics Ethanol Ethanol - pharmacology Forebrain Gene expression Lysine Male methylation Molecular modelling Motor Activity - physiology Neurons Original Phenotypes Phenotypic plasticity Physical training Rats, Wistar Reversal learning TrkA protein TrkA receptors Wheel running
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