EN1 Is a Transcriptional Dependency in Triple-Negative Breast Cancer Associated with Brain Metastasis

To define transcriptional dependencies of triple-negative breast cancer (TNBC), we identified transcription factors highly and specifically expressed in primary TNBCs and tested their requirement for cell growth in a panel of breast cancer cell lines. We found that (engrailed 1) is overexpressed in...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2019-08, Vol.79 (16), p.4173-4183
Hauptverfasser:	Peluffo, Guillermo, Subedee, Ashim, Harper, Nicholas W, Kingston, Natalie, Jovanović, Bojana, Flores, Felipe, Stevens, Laura E, Beca, Francisco, Trinh, Anne, Chilamakuri, Chandra Sekhar Reddy, Papachristou, Evangelia K, Murphy, Katherine, Su, Ying, Marusyk, Andriy, D'Santos, Clive S, Rueda, Oscar M, Beck, Andrew H, Caldas, Carlos, Carroll, Jason S, Polyak, Kornelia
Format:	Artikel
Sprache:	eng
Schlagworte:	Brain Neoplasms - genetics Brain Neoplasms - mortality Brain Neoplasms - secondary Co-Repressor Proteins - genetics Co-Repressor Proteins - metabolism Female Gene Expression Regulation, Neoplastic Homeodomain Proteins - genetics Humans MCF-7 Cells Prognosis Transcription Factors - genetics Triple Negative Breast Neoplasms - genetics Triple Negative Breast Neoplasms - mortality Triple Negative Breast Neoplasms - pathology Xenograft Model Antitumor Assays
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