Disruption of IRE1α through its kinase domain attenuates multiple myeloma

Multiple myeloma (MM) arises from malignant immunoglobulin (Ig)-secreting plasma cells and remains an incurable, often lethal disease despite therapeutic advances. The unfolded-protein response sensor IRE1α supports protein secretion by deploying a kinase–endoribonuclease module to activate the tran...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2019-08, Vol.116 (33), p.16420-16429
Hauptverfasser:	Harnoss, Jonathan M., Le Thomas, Adrien, Shemorry, Anna, Marsters, Scot A., Lawrence, David A., Lu, Min, Chen, Yung-Chia Ariel, Qing, Jing, Totpal, Klara, Kan, David, Segal, Ehud, Merchant, Mark, Reichelt, Mike, Wallweber, Heidi Ackerly, Wang, Weiru, Clark, Kevin, Kaufman, Susan, Beresini, Maureen H., Laing, Steven T., Sandoval, Wendy, Lorenzo, Maria, Wu, Jiansheng, Ly, Justin, De Bruyn, Tom, Heidersbach, Amy, Haley, Benjamin, Gogineni, Alvin, Weimer, Robby M., Lee, Dong, Braun, Marie-Gabrielle, Rudolph, Joachim, VanWyngarden, Michael J., Sherbenou, Daniel W., Gomez-Bougie, Patricia, Amiot, Martine, Acosta-Alvear, Diego, Walter, Peter, Ashkenazi, Avi
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Animal tissues Animals Biological Sciences Bortezomib Bortezomib - pharmacology Cancer Chemokines Cytokines Disruption Endoplasmic reticulum Endoplasmic Reticulum Stress - genetics Endoribonucleases - antagonists & inhibitors Endoribonucleases - genetics Female Gene Expression Regulation, Neoplastic - drug effects Hepatocytes Homeostasis Humans Immunoglobulins Inhibition Insulin Insulin secretion Kinases Lenalidomide - pharmacology Life Sciences Light chains Male Mice Middle Aged Multiple myeloma Multiple Myeloma - drug therapy Multiple Myeloma - genetics Multiple Myeloma - pathology Pancreas Perturbation Plasma cells PNAS Plus Protein Kinase Inhibitors - pharmacology Protein-Serine-Threonine Kinases - antagonists & inhibitors Protein-Serine-Threonine Kinases - genetics Proteins Signal Transduction - drug effects Therapeutic applications Tumors Unfolded Protein Response - genetics Viability X-Box Binding Protein 1 - genetics Xenograft Model Antitumor Assays
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!