Phase separation and clustering of an ABC transporter in Mycobacterium tuberculosis

Phase separation drives numerous cellular processes, ranging from the formation of membrane-less organelles to the cooperative assembly of signaling proteins. Features such as multivalency and intrinsic disorder that enable condensate formation are found not only in cytosolic and nuclear proteins, b...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2019-08, Vol.116 (33), p.16326-16331
Hauptverfasser:	Heinkel, Florian, Abraham, Libin, Ko, Mary, Chao, Joseph, Bach, Horacio, Hui, Lok Tin, Li, Haoran, Zhu, Mang, Ling, Yeou Mei, Rogalski, Jason C., Scurll, Joshua, Bui, Jennifer M., Mayor, Thibault, Gold, Michael R., Chou, Keng C., Av-Gay, Yossef, McIntosh, Lawrence P., Gsponer, Jörg
Format:	Artikel
Sprache:	eng
Schlagworte:	ABC transporter ABC transporters ATP-Binding Cassette Transporters - chemistry ATP-Binding Cassette Transporters - genetics Biological Sciences Clustering Condensates Cytosol - metabolism Domains Forkhead protein Gene Expression Regulation, Bacterial - genetics Homology Humans Intracellular signalling Kinases Lipid bilayers Lipid Bilayers - metabolism Lipids Localization Membrane Proteins - genetics Membrane Proteins - ultrastructure Microscopy Modules Mycobacterium smegmatis Mycobacterium smegmatis - genetics Mycobacterium smegmatis - pathogenicity Mycobacterium tuberculosis Mycobacterium tuberculosis - genetics Mycobacterium tuberculosis - pathogenicity Mycobacterium tuberculosis - ultrastructure Nuclear Proteins - genetics Organelles Phase separation Phosphorylation Phosphorylation - genetics Proteins Serine Signal Transduction - genetics Signaling Single Molecule Imaging Threonine Tuberculosis Tuberculosis - genetics Tuberculosis - microbiology Yeast Yeasts
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