The Natural Product Butylcycloheptyl Prodiginine Binds Pre-miR-21, Inhibits Dicer-Mediated Processing of Pre-miR-21, and Blocks Cellular Proliferation

Identification of RNA-interacting pharmacophores could provide chemical probes and, potentially, small molecules for RNA-based therapeutics. Using a high-throughput differential scanning fluorimetry assay, we identified small-molecule natural products with the capacity to bind the discrete stem-loop...

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Veröffentlicht in:	Cell chemical biology 2019-08, Vol.26 (8), p.1133-1142.e4
Hauptverfasser:	Matarlo, Joe S, Krumpe, Lauren R H, Heinz, William F, Oh, Daniel, Shenoy, Shilpa R, Thomas, Cheryl L, Goncharova, Ekaterina I, Lockett, Stephen J, O'Keefe, Barry R
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites - drug effects Biological Products - chemistry Biological Products - pharmacology Cell Proliferation - drug effects Cell Survival - drug effects Dose-Response Relationship, Drug HCT116 Cells Humans MicroRNAs - antagonists & inhibitors MicroRNAs - metabolism Molecular Structure Optical Imaging Prodigiosin - analogs & derivatives Prodigiosin - chemistry Prodigiosin - pharmacology Structure-Activity Relationship Tumor Cells, Cultured
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