Cytokine-Regulated Phosphorylation and Activation of TET2 by JAK2 in Hematopoiesis

Even though the Ten-eleven translocation (TET) enzymes catalyze the generation of 5-hydroxymethylcytosines required for lineage commitment and subsequent differentiation of stem cells into erythroid cells, the mechanisms that link extracellular signals to TET activation and DNA hydroxymethylation ar...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Cancer discovery 2019-06, Vol.9 (6), p.778-795
Hauptverfasser:	Jeong, Jong Jin, Gu, Xiaorong, Nie, Ji, Sundaravel, Sriram, Liu, Hui, Kuo, Wen-Liang, Bhagat, Tushar D, Pradhan, Kith, Cao, John, Nischal, Sangeeta, McGraw, Kathy L, Bhattacharyya, Sanchari, Bishop, Michael R, Artz, Andrew, Thirman, Michael J, Moliterno, Alison, Ji, Peng, Levine, Ross L, Godley, Lucy A, Steidl, Ulrich, Bieker, James J, List, Alan F, Saunthararajah, Yogen, He, Chuan, Verma, Amit, Wickrema, Amittha
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers Cytokines - metabolism Dioxygenases DNA-Binding Proteins - genetics Hematopoiesis - genetics Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - metabolism Humans Janus Kinase 2 - metabolism Phosphorylation Proto-Oncogene Proteins - genetics Transcriptional Activation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!