Age-Related Alterations in Gait Function in Freely Moving Male C57BL/6 Mice: Translational Relevance of Decreased Cadence and Increased Gait Variability
Abstract Age-related gait dysfunction and balance disorders are a major cause of falls and injury in the elderly population. Epidemiological studies have shown that disturbances in gait coordination which manifest with age are associated with increased morbidity and mortality, impaired cognitive cap...
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creator | Tarantini, Stefano Yabluchanskiy, Andriy Fülöp, Gábor A Kiss, Tamas Perz, Aleksandra O’Connor, Daniel Johnson, Emily Sorond, Farzaneh Ungvari, Zoltan I Csiszar, Anna |
description | Abstract
Age-related gait dysfunction and balance disorders are a major cause of falls and injury in the elderly population. Epidemiological studies have shown that disturbances in gait coordination which manifest with age are associated with increased morbidity and mortality, impaired cognitive capacity, as well as reduced level of function and loss of independence. In geroscience, mice are the most frequently used model system to test efficiency of antiaging interventions. Despite the clinical importance of age-related gait abnormalities in older adults, the impact of aging on mouse gait coordination is not well documented in the literature. To characterize the effect of aging on mouse gait, we assessed gait function in young (3-month-old) and aged (24-month-old) freely moving C57BL/6 mice using the semiautomated, highly sensitive CatWalk XT system for quantitative assessment of footfall and motor performance. We found that aged mice exhibited significantly decreased cadence and increased stride time variability. Aging also tended to alter footfall patterns. In aged mice, speed, swing speed, stride length, duty cycle, base of support, terminal dual stance, the regularity index, and the gait symmetry index were unaltered. Thus, aging is associated with characteristic alterations in gait function in C57BL/6 mice, which could potentially be assessed as clinically relevant endpoints in geroscience studies testing the effects of antiaging interventions. |
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Age-related gait dysfunction and balance disorders are a major cause of falls and injury in the elderly population. Epidemiological studies have shown that disturbances in gait coordination which manifest with age are associated with increased morbidity and mortality, impaired cognitive capacity, as well as reduced level of function and loss of independence. In geroscience, mice are the most frequently used model system to test efficiency of antiaging interventions. Despite the clinical importance of age-related gait abnormalities in older adults, the impact of aging on mouse gait coordination is not well documented in the literature. To characterize the effect of aging on mouse gait, we assessed gait function in young (3-month-old) and aged (24-month-old) freely moving C57BL/6 mice using the semiautomated, highly sensitive CatWalk XT system for quantitative assessment of footfall and motor performance. We found that aged mice exhibited significantly decreased cadence and increased stride time variability. Aging also tended to alter footfall patterns. In aged mice, speed, swing speed, stride length, duty cycle, base of support, terminal dual stance, the regularity index, and the gait symmetry index were unaltered. Thus, aging is associated with characteristic alterations in gait function in C57BL/6 mice, which could potentially be assessed as clinically relevant endpoints in geroscience studies testing the effects of antiaging interventions.</description><identifier>ISSN: 1079-5006</identifier><identifier>EISSN: 1758-535X</identifier><identifier>DOI: 10.1093/gerona/gly242</identifier><identifier>PMID: 30383221</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Aging ; Balance ; Cognitive ability ; Coordination ; Epidemiology ; Gait ; Geriatrics ; Morbidity ; Motor task performance ; Older people ; Population studies ; Rodents ; The Journal of Gerontology: Translational Section (Gait)</subject><ispartof>The journals of gerontology. Series A, Biological sciences and medical sciences, 2019-08, Vol.74 (9), p.1417-1421</ispartof><rights>The Author(s) 2018. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. 2018</rights><rights>The Author(s) 2018. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</rights><rights>Copyright Oxford University Press Sep 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-7dd78d700955c8198be4e0852190477d538015a52c057907dc4b42fe08cf9d243</citedby><cites>FETCH-LOGICAL-c448t-7dd78d700955c8198be4e0852190477d538015a52c057907dc4b42fe08cf9d243</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,1578,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30383221$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tarantini, Stefano</creatorcontrib><creatorcontrib>Yabluchanskiy, Andriy</creatorcontrib><creatorcontrib>Fülöp, Gábor A</creatorcontrib><creatorcontrib>Kiss, Tamas</creatorcontrib><creatorcontrib>Perz, Aleksandra</creatorcontrib><creatorcontrib>O’Connor, Daniel</creatorcontrib><creatorcontrib>Johnson, Emily</creatorcontrib><creatorcontrib>Sorond, Farzaneh</creatorcontrib><creatorcontrib>Ungvari, Zoltan I</creatorcontrib><creatorcontrib>Csiszar, Anna</creatorcontrib><title>Age-Related Alterations in Gait Function in Freely Moving Male C57BL/6 Mice: Translational Relevance of Decreased Cadence and Increased Gait Variability</title><title>The journals of gerontology. Series A, Biological sciences and medical sciences</title><addtitle>J Gerontol A Biol Sci Med Sci</addtitle><description>Abstract
Age-related gait dysfunction and balance disorders are a major cause of falls and injury in the elderly population. Epidemiological studies have shown that disturbances in gait coordination which manifest with age are associated with increased morbidity and mortality, impaired cognitive capacity, as well as reduced level of function and loss of independence. In geroscience, mice are the most frequently used model system to test efficiency of antiaging interventions. Despite the clinical importance of age-related gait abnormalities in older adults, the impact of aging on mouse gait coordination is not well documented in the literature. To characterize the effect of aging on mouse gait, we assessed gait function in young (3-month-old) and aged (24-month-old) freely moving C57BL/6 mice using the semiautomated, highly sensitive CatWalk XT system for quantitative assessment of footfall and motor performance. We found that aged mice exhibited significantly decreased cadence and increased stride time variability. Aging also tended to alter footfall patterns. In aged mice, speed, swing speed, stride length, duty cycle, base of support, terminal dual stance, the regularity index, and the gait symmetry index were unaltered. Thus, aging is associated with characteristic alterations in gait function in C57BL/6 mice, which could potentially be assessed as clinically relevant endpoints in geroscience studies testing the effects of antiaging interventions.</description><subject>Aging</subject><subject>Balance</subject><subject>Cognitive ability</subject><subject>Coordination</subject><subject>Epidemiology</subject><subject>Gait</subject><subject>Geriatrics</subject><subject>Morbidity</subject><subject>Motor task performance</subject><subject>Older people</subject><subject>Population studies</subject><subject>Rodents</subject><subject>The Journal of Gerontology: Translational Section (Gait)</subject><issn>1079-5006</issn><issn>1758-535X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNqFkU9vFCEYxidGY2v16NWQePEyLjDDAB5M1rVbm-zGxFTjjbDwzkjDwgozm-w38eN2ptvWPxe5QB5-eZ4XnqJ4SfBbgmU16yDFoGedP9CaPipOCWeiZBX7_ng8Yy5LhnFzUjzL-RpPi9GnxUmFK1FRSk6LX_MOyi_gdQ8WzX0PSfcuhoxcQBfa9Wg5BDMpk7BMAP6A1nHvQofW2gNaMP5hNWvQ2hl4h66SDtnfOmiPRlvY62AAxRZ9BJNA5zFloS1Mog4WXYZ79Tbsm05Ob5x3_eF58aTVPsOLu_2s-Lo8v1p8KlefLy4X81Vp6lr0JbeWC8sxlowZQaTYQA1YMEokrjm3rBKYMM2owYxLzK2pNzVtR8S00tK6OiveH313w2YL1kDok_Zql9xWp4OK2qm_b4L7obq4V00jG07YaPDmziDFnwPkXm1dNuC9DhCHrCihXDIs5ZT1-h_0Og5p_KqRoqKSTFS1HKnySJkUc07QPgxDsJo6V8fO1bHzkX_15wse6PuSf08Yh91_vG4A7ZW3mQ</recordid><startdate>20190816</startdate><enddate>20190816</enddate><creator>Tarantini, Stefano</creator><creator>Yabluchanskiy, Andriy</creator><creator>Fülöp, Gábor A</creator><creator>Kiss, Tamas</creator><creator>Perz, Aleksandra</creator><creator>O’Connor, Daniel</creator><creator>Johnson, Emily</creator><creator>Sorond, Farzaneh</creator><creator>Ungvari, Zoltan I</creator><creator>Csiszar, Anna</creator><general>Oxford University Press</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20190816</creationdate><title>Age-Related Alterations in Gait Function in Freely Moving Male C57BL/6 Mice: Translational Relevance of Decreased Cadence and Increased Gait Variability</title><author>Tarantini, Stefano ; Yabluchanskiy, Andriy ; Fülöp, Gábor A ; Kiss, Tamas ; Perz, Aleksandra ; O’Connor, Daniel ; Johnson, Emily ; Sorond, Farzaneh ; Ungvari, Zoltan I ; Csiszar, Anna</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-7dd78d700955c8198be4e0852190477d538015a52c057907dc4b42fe08cf9d243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Aging</topic><topic>Balance</topic><topic>Cognitive ability</topic><topic>Coordination</topic><topic>Epidemiology</topic><topic>Gait</topic><topic>Geriatrics</topic><topic>Morbidity</topic><topic>Motor task performance</topic><topic>Older people</topic><topic>Population studies</topic><topic>Rodents</topic><topic>The Journal of Gerontology: Translational Section (Gait)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tarantini, Stefano</creatorcontrib><creatorcontrib>Yabluchanskiy, Andriy</creatorcontrib><creatorcontrib>Fülöp, Gábor A</creatorcontrib><creatorcontrib>Kiss, Tamas</creatorcontrib><creatorcontrib>Perz, Aleksandra</creatorcontrib><creatorcontrib>O’Connor, Daniel</creatorcontrib><creatorcontrib>Johnson, Emily</creatorcontrib><creatorcontrib>Sorond, Farzaneh</creatorcontrib><creatorcontrib>Ungvari, Zoltan I</creatorcontrib><creatorcontrib>Csiszar, Anna</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The journals of gerontology. 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Series A, Biological sciences and medical sciences</jtitle><addtitle>J Gerontol A Biol Sci Med Sci</addtitle><date>2019-08-16</date><risdate>2019</risdate><volume>74</volume><issue>9</issue><spage>1417</spage><epage>1421</epage><pages>1417-1421</pages><issn>1079-5006</issn><eissn>1758-535X</eissn><abstract>Abstract
Age-related gait dysfunction and balance disorders are a major cause of falls and injury in the elderly population. Epidemiological studies have shown that disturbances in gait coordination which manifest with age are associated with increased morbidity and mortality, impaired cognitive capacity, as well as reduced level of function and loss of independence. In geroscience, mice are the most frequently used model system to test efficiency of antiaging interventions. Despite the clinical importance of age-related gait abnormalities in older adults, the impact of aging on mouse gait coordination is not well documented in the literature. To characterize the effect of aging on mouse gait, we assessed gait function in young (3-month-old) and aged (24-month-old) freely moving C57BL/6 mice using the semiautomated, highly sensitive CatWalk XT system for quantitative assessment of footfall and motor performance. We found that aged mice exhibited significantly decreased cadence and increased stride time variability. Aging also tended to alter footfall patterns. In aged mice, speed, swing speed, stride length, duty cycle, base of support, terminal dual stance, the regularity index, and the gait symmetry index were unaltered. Thus, aging is associated with characteristic alterations in gait function in C57BL/6 mice, which could potentially be assessed as clinically relevant endpoints in geroscience studies testing the effects of antiaging interventions.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>30383221</pmid><doi>10.1093/gerona/gly242</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Aging Balance Cognitive ability Coordination Epidemiology Gait Geriatrics Morbidity Motor task performance Older people Population studies Rodents The Journal of Gerontology: Translational Section (Gait) |
title | Age-Related Alterations in Gait Function in Freely Moving Male C57BL/6 Mice: Translational Relevance of Decreased Cadence and Increased Gait Variability |
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