Age-Related Alterations in Gait Function in Freely Moving Male C57BL/6 Mice: Translational Relevance of Decreased Cadence and Increased Gait Variability

Abstract Age-related gait dysfunction and balance disorders are a major cause of falls and injury in the elderly population. Epidemiological studies have shown that disturbances in gait coordination which manifest with age are associated with increased morbidity and mortality, impaired cognitive cap...

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Veröffentlicht in:The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2019-08, Vol.74 (9), p.1417-1421
Hauptverfasser: Tarantini, Stefano, Yabluchanskiy, Andriy, Fülöp, Gábor A, Kiss, Tamas, Perz, Aleksandra, O’Connor, Daniel, Johnson, Emily, Sorond, Farzaneh, Ungvari, Zoltan I, Csiszar, Anna
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container_issue 9
container_start_page 1417
container_title The journals of gerontology. Series A, Biological sciences and medical sciences
container_volume 74
creator Tarantini, Stefano
Yabluchanskiy, Andriy
Fülöp, Gábor A
Kiss, Tamas
Perz, Aleksandra
O’Connor, Daniel
Johnson, Emily
Sorond, Farzaneh
Ungvari, Zoltan I
Csiszar, Anna
description Abstract Age-related gait dysfunction and balance disorders are a major cause of falls and injury in the elderly population. Epidemiological studies have shown that disturbances in gait coordination which manifest with age are associated with increased morbidity and mortality, impaired cognitive capacity, as well as reduced level of function and loss of independence. In geroscience, mice are the most frequently used model system to test efficiency of antiaging interventions. Despite the clinical importance of age-related gait abnormalities in older adults, the impact of aging on mouse gait coordination is not well documented in the literature. To characterize the effect of aging on mouse gait, we assessed gait function in young (3-month-old) and aged (24-month-old) freely moving C57BL/6 mice using the semiautomated, highly sensitive CatWalk XT system for quantitative assessment of footfall and motor performance. We found that aged mice exhibited significantly decreased cadence and increased stride time variability. Aging also tended to alter footfall patterns. In aged mice, speed, swing speed, stride length, duty cycle, base of support, terminal dual stance, the regularity index, and the gait symmetry index were unaltered. Thus, aging is associated with characteristic alterations in gait function in C57BL/6 mice, which could potentially be assessed as clinically relevant endpoints in geroscience studies testing the effects of antiaging interventions.
doi_str_mv 10.1093/gerona/gly242
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Epidemiological studies have shown that disturbances in gait coordination which manifest with age are associated with increased morbidity and mortality, impaired cognitive capacity, as well as reduced level of function and loss of independence. In geroscience, mice are the most frequently used model system to test efficiency of antiaging interventions. Despite the clinical importance of age-related gait abnormalities in older adults, the impact of aging on mouse gait coordination is not well documented in the literature. To characterize the effect of aging on mouse gait, we assessed gait function in young (3-month-old) and aged (24-month-old) freely moving C57BL/6 mice using the semiautomated, highly sensitive CatWalk XT system for quantitative assessment of footfall and motor performance. We found that aged mice exhibited significantly decreased cadence and increased stride time variability. Aging also tended to alter footfall patterns. In aged mice, speed, swing speed, stride length, duty cycle, base of support, terminal dual stance, the regularity index, and the gait symmetry index were unaltered. Thus, aging is associated with characteristic alterations in gait function in C57BL/6 mice, which could potentially be assessed as clinically relevant endpoints in geroscience studies testing the effects of antiaging interventions.</description><identifier>ISSN: 1079-5006</identifier><identifier>EISSN: 1758-535X</identifier><identifier>DOI: 10.1093/gerona/gly242</identifier><identifier>PMID: 30383221</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Aging ; Balance ; Cognitive ability ; Coordination ; Epidemiology ; Gait ; Geriatrics ; Morbidity ; Motor task performance ; Older people ; Population studies ; Rodents ; The Journal of Gerontology: Translational Section (Gait)</subject><ispartof>The journals of gerontology. 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identifier ISSN: 1079-5006
ispartof The journals of gerontology. Series A, Biological sciences and medical sciences, 2019-08, Vol.74 (9), p.1417-1421
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source Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection
subjects Aging
Balance
Cognitive ability
Coordination
Epidemiology
Gait
Geriatrics
Morbidity
Motor task performance
Older people
Population studies
Rodents
The Journal of Gerontology: Translational Section (Gait)
title Age-Related Alterations in Gait Function in Freely Moving Male C57BL/6 Mice: Translational Relevance of Decreased Cadence and Increased Gait Variability
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