Angiogenesis, Lymphangiogenesis, and the Immune Response in South African Preeclamptic Women Receiving HAART
This review highlights the role of angiogenesis, lymphangiogenesis, and immune markers in human immunodeficiency virus (HIV)-associated preeclamptic (PE) pregnancies in an attempt to unravel the mysteries underlying the duality of both conditions in South Africa. Studies demonstrate that HIV-infecte...
Gespeichert in:
| Veröffentlicht in: | International journal of molecular sciences 2019-07, Vol.20 (15), p.3728 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 15 |
| container_start_page | 3728 |
| container_title | International journal of molecular sciences |
| container_volume | 20 |
| creator | Naicker, Thajasvarie Phoswa, Wendy N Onyangunga, Onankoy A Gathiram, Premjith Moodley, Jagidesa |
| description | This review highlights the role of angiogenesis, lymphangiogenesis, and immune markers in human immunodeficiency virus (HIV)-associated preeclamptic (PE) pregnancies in an attempt to unravel the mysteries underlying the duality of both conditions in South Africa.
Studies demonstrate that HIV-infected pregnant women develop PE at a lower frequency than uninfected women. In contrast, women receiving highly active anti-retroviral therapy (HAART) are more inclined to develop PE, stemming from an imbalance of angiogenesis, lymphangiogenesis, and immune response.
In view of the paradoxical effect of HIV infection on PE development, this study examines angiogenesis, lymphangiogenesis, and immune markers in the highly HIV endemic area of KwaZulu-Natal. We believe that HAART re-constitutes the immune response in PE, thereby predisposing women to PE development. This susceptibility is due to an imbalance in the angiogenic/lymphangiogenic/immune response as compared to normotensive pregnant women. Further large-scale studies are urgently required to investigate the effect of the duration of HAART on PE development. |
| doi_str_mv | 10.3390/ijms20153728 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6696390</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2333646407</sourcerecordid><originalsourceid>FETCH-LOGICAL-c412t-16a2ac17678510e4f967702439e10130352e0d40ca5ba8d5926cab1d65bfbe93</originalsourceid><addsrcrecordid>eNpdkctLxDAQxoMoPlZvniXgxYOrebTp9iIUUXdhQdEFjyFNp7tZmqQm7YL_vRUfrJ5mmPnxMd98CJ1ScsV5Tq7N2kZGaMozNtlBhzRhbEyIyHa3-gN0FOOaEMZZmu-jA065EDRlh6gp3NL4JTiIJl7i-bttV-rPSLkKdyvAM2t7B_gZYutdBGwcfvF9t8JFHYxWDj8FAN0o23ZG41dvwQ2wBrMxbomnRfG8OEZ7tWoinHzXEVrc3y1up-P548PstpiPdUJZN6ZCMaVpJrJJSgkkdS6yjLCE50AJ5YSnDEiVEK3SUk2qNGdCq5JWIi3rEnI-Qjdfsm1fWqg0uC6oRrbBWBXepVdG_t04s5JLv5FC5GJ46SBw8S0Q_FsPsZPWRA1Noxz4PkrGhoOynA5PH6Hzf-ja98EN7iTjnItEJCQbqMsvSgcfY4D69xhK5GeKcjvFAT_bNvAL_8TGPwDPXJix</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2333646407</pqid></control><display><type>article</type><title>Angiogenesis, Lymphangiogenesis, and the Immune Response in South African Preeclamptic Women Receiving HAART</title><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Naicker, Thajasvarie ; Phoswa, Wendy N ; Onyangunga, Onankoy A ; Gathiram, Premjith ; Moodley, Jagidesa</creator><creatorcontrib>Naicker, Thajasvarie ; Phoswa, Wendy N ; Onyangunga, Onankoy A ; Gathiram, Premjith ; Moodley, Jagidesa</creatorcontrib><description>This review highlights the role of angiogenesis, lymphangiogenesis, and immune markers in human immunodeficiency virus (HIV)-associated preeclamptic (PE) pregnancies in an attempt to unravel the mysteries underlying the duality of both conditions in South Africa.
Studies demonstrate that HIV-infected pregnant women develop PE at a lower frequency than uninfected women. In contrast, women receiving highly active anti-retroviral therapy (HAART) are more inclined to develop PE, stemming from an imbalance of angiogenesis, lymphangiogenesis, and immune response.
In view of the paradoxical effect of HIV infection on PE development, this study examines angiogenesis, lymphangiogenesis, and immune markers in the highly HIV endemic area of KwaZulu-Natal. We believe that HAART re-constitutes the immune response in PE, thereby predisposing women to PE development. This susceptibility is due to an imbalance in the angiogenic/lymphangiogenic/immune response as compared to normotensive pregnant women. Further large-scale studies are urgently required to investigate the effect of the duration of HAART on PE development.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms20153728</identifier><identifier>PMID: 31366152</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Angiogenesis ; Antiretroviral Therapy, Highly Active - adverse effects ; Arginine ; Cell adhesion & migration ; Cytokines - blood ; Developing countries ; Female ; Gene expression ; Gestational age ; Highly active antiretroviral therapy ; HIV ; HIV Infections - drug therapy ; HIV Infections - immunology ; HIV Infections - physiopathology ; Human immunodeficiency virus ; Humans ; Hyperactivity ; Hypertension ; Immune response ; Immune system ; Industrialized nations ; Infections ; Kinases ; LDCs ; Lymphatic System - drug effects ; Lysine ; Maternal mortality ; Neovascularization, Physiologic - drug effects ; Nitric oxide ; Nitric-oxide synthase ; NOS3 protein ; Permeability ; Pre-eclampsia ; Pre-Eclampsia - immunology ; Pre-Eclampsia - physiopathology ; Pre-Eclampsia - virology ; Preeclampsia ; Pregnancy ; Pregnancy Complications, Infectious - drug therapy ; Pregnancy Complications, Infectious - immunology ; Pregnancy Complications, Infectious - physiopathology ; Premature birth ; Proteins ; Review ; Small for gestational age ; Tat protein ; Transforming growth factor-b1 ; Vascular endothelial growth factor ; Womens health</subject><ispartof>International journal of molecular sciences, 2019-07, Vol.20 (15), p.3728</ispartof><rights>2019. This work is licensed under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2019 by the authors. 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-16a2ac17678510e4f967702439e10130352e0d40ca5ba8d5926cab1d65bfbe93</citedby><cites>FETCH-LOGICAL-c412t-16a2ac17678510e4f967702439e10130352e0d40ca5ba8d5926cab1d65bfbe93</cites><orcidid>0000-0002-6648-8833</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6696390/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6696390/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31366152$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Naicker, Thajasvarie</creatorcontrib><creatorcontrib>Phoswa, Wendy N</creatorcontrib><creatorcontrib>Onyangunga, Onankoy A</creatorcontrib><creatorcontrib>Gathiram, Premjith</creatorcontrib><creatorcontrib>Moodley, Jagidesa</creatorcontrib><title>Angiogenesis, Lymphangiogenesis, and the Immune Response in South African Preeclamptic Women Receiving HAART</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>This review highlights the role of angiogenesis, lymphangiogenesis, and immune markers in human immunodeficiency virus (HIV)-associated preeclamptic (PE) pregnancies in an attempt to unravel the mysteries underlying the duality of both conditions in South Africa.
Studies demonstrate that HIV-infected pregnant women develop PE at a lower frequency than uninfected women. In contrast, women receiving highly active anti-retroviral therapy (HAART) are more inclined to develop PE, stemming from an imbalance of angiogenesis, lymphangiogenesis, and immune response.
In view of the paradoxical effect of HIV infection on PE development, this study examines angiogenesis, lymphangiogenesis, and immune markers in the highly HIV endemic area of KwaZulu-Natal. We believe that HAART re-constitutes the immune response in PE, thereby predisposing women to PE development. This susceptibility is due to an imbalance in the angiogenic/lymphangiogenic/immune response as compared to normotensive pregnant women. Further large-scale studies are urgently required to investigate the effect of the duration of HAART on PE development.</description><subject>Angiogenesis</subject><subject>Antiretroviral Therapy, Highly Active - adverse effects</subject><subject>Arginine</subject><subject>Cell adhesion & migration</subject><subject>Cytokines - blood</subject><subject>Developing countries</subject><subject>Female</subject><subject>Gene expression</subject><subject>Gestational age</subject><subject>Highly active antiretroviral therapy</subject><subject>HIV</subject><subject>HIV Infections - drug therapy</subject><subject>HIV Infections - immunology</subject><subject>HIV Infections - physiopathology</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Hyperactivity</subject><subject>Hypertension</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Industrialized nations</subject><subject>Infections</subject><subject>Kinases</subject><subject>LDCs</subject><subject>Lymphatic System - drug effects</subject><subject>Lysine</subject><subject>Maternal mortality</subject><subject>Neovascularization, Physiologic - drug effects</subject><subject>Nitric oxide</subject><subject>Nitric-oxide synthase</subject><subject>NOS3 protein</subject><subject>Permeability</subject><subject>Pre-eclampsia</subject><subject>Pre-Eclampsia - immunology</subject><subject>Pre-Eclampsia - physiopathology</subject><subject>Pre-Eclampsia - virology</subject><subject>Preeclampsia</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Infectious - drug therapy</subject><subject>Pregnancy Complications, Infectious - immunology</subject><subject>Pregnancy Complications, Infectious - physiopathology</subject><subject>Premature birth</subject><subject>Proteins</subject><subject>Review</subject><subject>Small for gestational age</subject><subject>Tat protein</subject><subject>Transforming growth factor-b1</subject><subject>Vascular endothelial growth factor</subject><subject>Womens health</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkctLxDAQxoMoPlZvniXgxYOrebTp9iIUUXdhQdEFjyFNp7tZmqQm7YL_vRUfrJ5mmPnxMd98CJ1ScsV5Tq7N2kZGaMozNtlBhzRhbEyIyHa3-gN0FOOaEMZZmu-jA065EDRlh6gp3NL4JTiIJl7i-bttV-rPSLkKdyvAM2t7B_gZYutdBGwcfvF9t8JFHYxWDj8FAN0o23ZG41dvwQ2wBrMxbomnRfG8OEZ7tWoinHzXEVrc3y1up-P548PstpiPdUJZN6ZCMaVpJrJJSgkkdS6yjLCE50AJ5YSnDEiVEK3SUk2qNGdCq5JWIi3rEnI-Qjdfsm1fWqg0uC6oRrbBWBXepVdG_t04s5JLv5FC5GJ46SBw8S0Q_FsPsZPWRA1Noxz4PkrGhoOynA5PH6Hzf-ja98EN7iTjnItEJCQbqMsvSgcfY4D69xhK5GeKcjvFAT_bNvAL_8TGPwDPXJix</recordid><startdate>20190730</startdate><enddate>20190730</enddate><creator>Naicker, Thajasvarie</creator><creator>Phoswa, Wendy N</creator><creator>Onyangunga, Onankoy A</creator><creator>Gathiram, Premjith</creator><creator>Moodley, Jagidesa</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-6648-8833</orcidid></search><sort><creationdate>20190730</creationdate><title>Angiogenesis, Lymphangiogenesis, and the Immune Response in South African Preeclamptic Women Receiving HAART</title><author>Naicker, Thajasvarie ; Phoswa, Wendy N ; Onyangunga, Onankoy A ; Gathiram, Premjith ; Moodley, Jagidesa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-16a2ac17678510e4f967702439e10130352e0d40ca5ba8d5926cab1d65bfbe93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Angiogenesis</topic><topic>Antiretroviral Therapy, Highly Active - adverse effects</topic><topic>Arginine</topic><topic>Cell adhesion & migration</topic><topic>Cytokines - blood</topic><topic>Developing countries</topic><topic>Female</topic><topic>Gene expression</topic><topic>Gestational age</topic><topic>Highly active antiretroviral therapy</topic><topic>HIV</topic><topic>HIV Infections - drug therapy</topic><topic>HIV Infections - immunology</topic><topic>HIV Infections - physiopathology</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>Hyperactivity</topic><topic>Hypertension</topic><topic>Immune response</topic><topic>Immune system</topic><topic>Industrialized nations</topic><topic>Infections</topic><topic>Kinases</topic><topic>LDCs</topic><topic>Lymphatic System - drug effects</topic><topic>Lysine</topic><topic>Maternal mortality</topic><topic>Neovascularization, Physiologic - drug effects</topic><topic>Nitric oxide</topic><topic>Nitric-oxide synthase</topic><topic>NOS3 protein</topic><topic>Permeability</topic><topic>Pre-eclampsia</topic><topic>Pre-Eclampsia - immunology</topic><topic>Pre-Eclampsia - physiopathology</topic><topic>Pre-Eclampsia - virology</topic><topic>Preeclampsia</topic><topic>Pregnancy</topic><topic>Pregnancy Complications, Infectious - drug therapy</topic><topic>Pregnancy Complications, Infectious - immunology</topic><topic>Pregnancy Complications, Infectious - physiopathology</topic><topic>Premature birth</topic><topic>Proteins</topic><topic>Review</topic><topic>Small for gestational age</topic><topic>Tat protein</topic><topic>Transforming growth factor-b1</topic><topic>Vascular endothelial growth factor</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Naicker, Thajasvarie</creatorcontrib><creatorcontrib>Phoswa, Wendy N</creatorcontrib><creatorcontrib>Onyangunga, Onankoy A</creatorcontrib><creatorcontrib>Gathiram, Premjith</creatorcontrib><creatorcontrib>Moodley, Jagidesa</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Naicker, Thajasvarie</au><au>Phoswa, Wendy N</au><au>Onyangunga, Onankoy A</au><au>Gathiram, Premjith</au><au>Moodley, Jagidesa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Angiogenesis, Lymphangiogenesis, and the Immune Response in South African Preeclamptic Women Receiving HAART</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2019-07-30</date><risdate>2019</risdate><volume>20</volume><issue>15</issue><spage>3728</spage><pages>3728-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>This review highlights the role of angiogenesis, lymphangiogenesis, and immune markers in human immunodeficiency virus (HIV)-associated preeclamptic (PE) pregnancies in an attempt to unravel the mysteries underlying the duality of both conditions in South Africa.
Studies demonstrate that HIV-infected pregnant women develop PE at a lower frequency than uninfected women. In contrast, women receiving highly active anti-retroviral therapy (HAART) are more inclined to develop PE, stemming from an imbalance of angiogenesis, lymphangiogenesis, and immune response.
In view of the paradoxical effect of HIV infection on PE development, this study examines angiogenesis, lymphangiogenesis, and immune markers in the highly HIV endemic area of KwaZulu-Natal. We believe that HAART re-constitutes the immune response in PE, thereby predisposing women to PE development. This susceptibility is due to an imbalance in the angiogenic/lymphangiogenic/immune response as compared to normotensive pregnant women. Further large-scale studies are urgently required to investigate the effect of the duration of HAART on PE development.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>31366152</pmid><doi>10.3390/ijms20153728</doi><orcidid>https://orcid.org/0000-0002-6648-8833</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1422-0067 |
| ispartof | International journal of molecular sciences, 2019-07, Vol.20 (15), p.3728 |
| issn | 1422-0067 1661-6596 1422-0067 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6696390 |
| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Angiogenesis Antiretroviral Therapy, Highly Active - adverse effects Arginine Cell adhesion & migration Cytokines - blood Developing countries Female Gene expression Gestational age Highly active antiretroviral therapy HIV HIV Infections - drug therapy HIV Infections - immunology HIV Infections - physiopathology Human immunodeficiency virus Humans Hyperactivity Hypertension Immune response Immune system Industrialized nations Infections Kinases LDCs Lymphatic System - drug effects Lysine Maternal mortality Neovascularization, Physiologic - drug effects Nitric oxide Nitric-oxide synthase NOS3 protein Permeability Pre-eclampsia Pre-Eclampsia - immunology Pre-Eclampsia - physiopathology Pre-Eclampsia - virology Preeclampsia Pregnancy Pregnancy Complications, Infectious - drug therapy Pregnancy Complications, Infectious - immunology Pregnancy Complications, Infectious - physiopathology Premature birth Proteins Review Small for gestational age Tat protein Transforming growth factor-b1 Vascular endothelial growth factor Womens health |
| title | Angiogenesis, Lymphangiogenesis, and the Immune Response in South African Preeclamptic Women Receiving HAART |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-10T02%3A08%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Angiogenesis,%20Lymphangiogenesis,%20and%20the%20Immune%20Response%20in%20South%20African%20Preeclamptic%20Women%20Receiving%20HAART&rft.jtitle=International%20journal%20of%20molecular%20sciences&rft.au=Naicker,%20Thajasvarie&rft.date=2019-07-30&rft.volume=20&rft.issue=15&rft.spage=3728&rft.pages=3728-&rft.issn=1422-0067&rft.eissn=1422-0067&rft_id=info:doi/10.3390/ijms20153728&rft_dat=%3Cproquest_pubme%3E2333646407%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2333646407&rft_id=info:pmid/31366152&rfr_iscdi=true |