Acid sphingomyelinase plays a critical role in LPS- and cytokine-induced tissue factor procoagulant activity

Tissue factor (TF) is a cofactor for factor VIIa and the primary cellular initiator of coagulation. Typically, most TF on cell surfaces exists in a cryptic coagulant-inactive state but are transformed to a procoagulant form (decryption) following cell activation. Our recent studies in cell model sys...

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Veröffentlicht in:	Blood 2019-08, Vol.134 (7), p.645-655
Hauptverfasser:	Wang, Jue, Pendurthi, Usha R., Rao, L. Vijaya Mohan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Coagulation Cytokines - metabolism Human Umbilical Vein Endothelial Cells Humans Lipopolysaccharides - metabolism Mice, Inbred C57BL Monocytes - metabolism Sphingomyelin Phosphodiesterase - metabolism Thrombin - metabolism Thromboplastin - metabolism Thrombosis - metabolism Thrombosis and Hemostasis
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