An increase in plasma brain derived neurotrophic factor levels is related to n-3 polyunsaturated fatty acid efficacy in first episode schizophrenia: secondary outcome analysis of the OFFER randomized clinical trial

Rationale N−3 polyunsaturated fatty acids (n−3 PUFA) influence multiple biochemical mechanisms postulated in the pathogenesis of schizophrenia that may influence BDNF synthesis. Objectives A randomized placebo-controlled study was designed to compare the efficacy of a 26-week intervention composed o...

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Veröffentlicht in:	Psychopharmacology 2019-09, Vol.236 (9), p.2811-2822
Hauptverfasser:	Pawełczyk, Tomasz, Grancow-Grabka, Marta, Trafalska, Elżbieta, Szemraj, Janusz, Żurner, Natalia, Pawełczyk, Agnieszka
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical and Life Sciences Biomedicine Brain-derived neurotrophic factor Clinical trials Enzyme-linked immunosorbent assay Intracellular signalling Mental disorders Neurosciences Oils & fats Olive oil Original Investigation Patient outcomes Pharmacology/Toxicology Plasma Polyunsaturated fatty acids Protein binding Psychiatry Schizophrenia Transcription factors Unsaturated fatty acids
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