HIV Diversity and Genetic Compartmentalization in Blood and Testes during Suppressive Antiretroviral Therapy

HIV's ability to persist during suppressive antiretroviral therapy is the main barrier to cure. Immune-privileged tissues, such as the testes, may constitute distinctive sites of HIV persistence, but this has been challenging to study in humans. We analyzed the proviral burden and genetics in t...

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Veröffentlicht in:	Journal of virology 2019-09, Vol.93 (17)
Hauptverfasser:	Miller, Rachel L, Ponte, Rosalie, Jones, Bradley R, Kinloch, Natalie N, Omondi, Fredrick H, Jenabian, Mohammad-Ali, Dupuy, Franck P, Fromentin, Remi, Brassard, Pierre, Mehraj, Vikram, Chomont, Nicolas, Poon, Art F Y, Joy, Jeffrey B, Brumme, Zabrina L, Routy, Jean-Pierre
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Retroviral Agents - therapeutic use Case-Control Studies Clonal Evolution Elective Surgical Procedures Genetic Diversity and Evolution Genetic Variation HIV Infections - blood HIV Infections - drug therapy HIV-1 - classification HIV-1 - drug effects HIV-1 - genetics Humans Male nef Gene Products, Human Immunodeficiency Virus - genetics Phylogeny Sequence Analysis, RNA Sex Reassignment Surgery Testis - drug effects Testis - surgery Testis - virology
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