Plasticizer Interaction With the Heart: Chemicals Used in Plastic Medical Devices Can Interfere With Cardiac Electrophysiology

BACKGROUND:Phthalates are used as plasticizers in the manufacturing of flexible, plastic medical products. Patients can be subjected to high phthalate exposure through contact with plastic medical devices. We aimed to investigate the cardiac safety and biocompatibility of mono-2-ethylhexyl phthalate...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Circulation. Arrhythmia and electrophysiology 2019-07, Vol.12 (7), p.e007294-e007294
Hauptverfasser:	Jaimes, Rafael, McCullough, Damon, Siegel, Bryan, Swift, Luther, McInerney, Daniel, Hiebert, James, Perez-Alday, Erick A, Trenor, Beatriz, Sheng, Jiansong, Saiz, Javier, Tereshchenko, Larisa G, Posnack, Nikki Gillum
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects Animals Arrhythmias, Cardiac - chemically induced Arrhythmias, Cardiac - diagnosis Arrhythmias, Cardiac - metabolism Arrhythmias, Cardiac - physiopathology Computer Simulation Diethylhexyl Phthalate - analogs & derivatives Diethylhexyl Phthalate - toxicity Equipment and Supplies - adverse effects Equipment Design Heart Conduction System - drug effects Heart Conduction System - metabolism Heart Conduction System - physiopathology Heart Rate - drug effects Humans Isolated Heart Preparation Male Models, Cardiovascular Original Plasticizers - toxicity Rats, Sprague-Dawley Refractory Period, Electrophysiological - drug effects Risk Assessment Sodium Channels - drug effects Sodium Channels - metabolism Time Factors Voltage-Sensitive Dye Imaging
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!