Quantitative characterization of the regulation of iron metabolism in glioblastoma stem‐like cells using magnetophoresis

This study focuses on different iron regulation mechanisms of glioblastoma (GBM) cancer stem‐like cells (CSCs) and non‐stem tumor cells (NSTCs) using multiple approaches: cell viability, density, and magnetophoresis. GBM CSCs and NSTCs were exposed to elevated iron concentration, and their magnetic...

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Veröffentlicht in:	Biotechnology and bioengineering 2019-07, Vol.116 (7), p.1644-1655
Hauptverfasser:	Park, Kyoung‐Joo J., Kim, James, Testoff, Thomas, Adams, Joseph, Poklar, Miranda, Zborowski, Maciej, Venere, Monica, Chalmers, Jeffrey J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain Neoplasms - metabolism Brain Neoplasms - pathology Cell viability Energy gradient Ferritin Fluorescence Glioblastoma Glioblastoma - metabolism Glioblastoma - pathology Humans Iron Iron - metabolism Magnetic Fields Magnetic permeability Magnetic separation Magnetic separators Magnetic susceptibility Metabolism Mice Microfluidic Analytical Techniques Microfluidic devices Microfluidics Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Permanent magnets Quadrupoles Separators Settling velocity single cell magnetophoresis stem‐like cells Tumor cells
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