The transcription factor ThPOK suppresses Runx3 and imposes CD4+ lineage fate by inducing the SOCS suppressors of cytokine signaling

Lineage fate in the thymus is imposed by the antagonizing effects of the transcription factors ThPOK and Runx3. Park and colleagues show that ThPOK-induced SOCS factors are required for differentiation into the CD4 + T cell lineage. Lineage fate in the thymus is determined by mutually exclusive expr...

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