Roles of organic anion transporter 2 and equilibrative nucleoside transporter 1 in hepatic disposition and antiviral activity of entecavir during non‐pregnancy and pregnancy

Background and Purpose Entecavir (ETV), a first‐line antiviral drug against hepatitis B virus (HBV), has the possibility to be used to prevent mother‐to‐child transmission. The aim of present study was to clarify the mechanism of ETV uptake into hepatocytes and evaluate the alteration of ETV's...

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Veröffentlicht in:	British journal of pharmacology 2019-09, Vol.176 (17), p.3236-3249
Hauptverfasser:	Ma, Zhiyuan, Lu, Shuanghui, Sun, Dongli, Bai, Mengru, Jiang, Ting, Lin, Nengming, Zhou, Hui, Zeng, Su, Jiang, Huidi
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Animals Antiviral activity Antiviral Agents - chemistry Antiviral Agents - pharmacology Antiviral drugs Cell culture Cell lines Cell Proliferation - drug effects Cells, Cultured Dogs Dose-Response Relationship, Drug Equilibrative Nucleoside Transporter 1 - antagonists & inhibitors Equilibrative Nucleoside Transporter 1 - metabolism Female Guanine - analogs & derivatives Guanine - chemistry Guanine - pharmacology HEK293 Cells Hepatitis Hepatitis B Hepatitis B virus - drug effects Hepatocytes Hepatocytes - drug effects Hepatocytes - metabolism Humans Indomethacin - pharmacology Liver Mice Mice, Inbred ICR Nucleoside transporter Organic Anion Transporters, Sodium-Independent - antagonists & inhibitors Organic Anion Transporters, Sodium-Independent - metabolism Pregnancy Progesterone Research Paper Research Papers Structure-Activity Relationship Thioinosine - analogs & derivatives Thioinosine - pharmacology Viruses
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