Evaluation of a Series of β‑Secretase 1 Inhibitors Containing Novel Heteroaryl-Fused-Piperazine Amidine Warheads

Despite several years of research, only a handful of β-secretase (BACE) 1 inhibitors have entered clinical trials as potential therapeutics against Alzheimer’s disease. The intrinsic basic nature of low molecular weight, amidine-containing BACE 1 inhibitors makes them far from optimal as central ner...

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Veröffentlicht in:	ACS medicinal chemistry letters 2019-08, Vol.10 (8), p.1159-1165
Hauptverfasser:	Oehlrich, Daniel, Peschiulli, Aldo, Tresadern, Gary, Van Gool, Michiel, Vega, Juan Antonio, De Lucas, Ana Isabel, Alonso de Diego, Sergio A, Prokopcova, Hana, Austin, Nigel, Van Brandt, Sven, Surkyn, Michel, De Cleyn, Michel, Vos, Ann, Rombouts, Frederik J. R, Macdonald, Gregor, Moechars, Dieder, Gijsen, Harrie J. M, Trabanco, Andrés A
Format:	Artikel
Sprache:	eng
Schlagworte:	Letter
Online-Zugang:	Volltext
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