ASDAS is associated with both the extent and intensity of DW-MRI spinal inflammation in active axial spondyloarthritis
ObjectiveTo investigate the relationship between Ankylosing Spondylitis Disease Activity Score (ASDAS) and intensity of spinal inflammation measured by apparent diffusion coefficient (ADC) in MRI in participants with active axial spondyloarthritis (SpA).MethodsParticipants with axial SpA and back pa...
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| creator | Chung, Ho Yin Chui, Eva Tsz Fung Lee, Kam Ho Tsang, Helen Hoi Lun Chan, Shirley Chiu Wai Lau, Chak Sing |
| description | ObjectiveTo investigate the relationship between Ankylosing Spondylitis Disease Activity Score (ASDAS) and intensity of spinal inflammation measured by apparent diffusion coefficient (ADC) in MRI in participants with active axial spondyloarthritis (SpA).MethodsParticipants with axial SpA and back pain were recruited. Clinical, demographic, biochemical and imaging data were collected. ASDAS was calculated based on C reactive protein (CRP) and erythrocyte sedimentation rate (ESR). Inflammatory lesions were identified in short tau inversion recovery images and the corresponding ADC maps to determine the maximum apparent diffusion coefficient (ADCmax), normalised maximum ADC, mean apparent diffusion coefficient (ADCmean) and normalised mean ADC by two independent readers. Spondyloarthritis Research Consortium of Canada (SPARCC) spine and sacroiliac (SI) joint MRI indexes were determined. Univariate and multivariate linear regression models were used to determine the associations between of ASDAS with ADC values, SPARCC spine and SI MRI scores.ResultsEighty-two participants had identifiable ADC lesions. Multivariate analyses using ADCmax and SPARCC spine MRI as independent variables showed associations with ASDAS-CRP (ADCmax: B=0.27, p=0.02; SPARCC: B=0.32, p=0.01) and ASDAS-ESR (ADCmax: B=0.24, p=0.03; SPARCC: B=0.36, p |
| doi_str_mv | 10.1136/rmdopen-2019-001008 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6691514</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2288711582</sourcerecordid><originalsourceid>FETCH-LOGICAL-b472t-a692312e808a4b418606956ee5c476126dd3d566bbf931c12521e8ad66e045b13</originalsourceid><addsrcrecordid>eNqNkVFLHDEUhYNYqmz9BQUJ-OLL2Nxkkpl5KSxaW8EiqKWPITPJdLPMJNMku3X_vbG7Fe2TL8kN57uH3HsQ-gjkDICJT2HUfjKuoASaghAgpN5Dh5RwUfCGsf0X9QE6inFJMlQyVgF7jw4YlJw2jByi9fzuYn6HbcQqRt9ZlYzGf2xa4NbnIy0MNg_JuISV09i6XEabNtj3-OJn8f32CsfJOjVkqR_UOKpkvcsPrLpk1warB5vFOHmnN4NXIS2CTTZ-QO96NURztLtn6Mfll_vzb8X1zder8_l10ZYVTYUSDWVATU1qVbYl1IKIhgtjeFdWAqjQmmkuRNv2DYMOKKdgaqWFMKTkLbAZ-rz1nVbtaHSXBwlqkFOwowob6ZWVrxVnF_KXX0shGuB5YTN0ujMI_vfKxCRHGzszDMoZv4qS0hqAVqTiGT35D136Vci7-UvVFQCvaabYluqCjzGY_vkzQORTtHIXrXyKVm6jzV3HL-d47vkXZAbOtkA7Lt_k-AhuJLA5</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2288711582</pqid></control><display><type>article</type><title>ASDAS is associated with both the extent and intensity of DW-MRI spinal inflammation in active axial spondyloarthritis</title><source>BMJ Open Access Journals</source><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>PubMed Central Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Chung, Ho Yin ; Chui, Eva Tsz Fung ; Lee, Kam Ho ; Tsang, Helen Hoi Lun ; Chan, Shirley Chiu Wai ; Lau, Chak Sing</creator><creatorcontrib>Chung, Ho Yin ; Chui, Eva Tsz Fung ; Lee, Kam Ho ; Tsang, Helen Hoi Lun ; Chan, Shirley Chiu Wai ; Lau, Chak Sing</creatorcontrib><description>ObjectiveTo investigate the relationship between Ankylosing Spondylitis Disease Activity Score (ASDAS) and intensity of spinal inflammation measured by apparent diffusion coefficient (ADC) in MRI in participants with active axial spondyloarthritis (SpA).MethodsParticipants with axial SpA and back pain were recruited. Clinical, demographic, biochemical and imaging data were collected. ASDAS was calculated based on C reactive protein (CRP) and erythrocyte sedimentation rate (ESR). Inflammatory lesions were identified in short tau inversion recovery images and the corresponding ADC maps to determine the maximum apparent diffusion coefficient (ADCmax), normalised maximum ADC, mean apparent diffusion coefficient (ADCmean) and normalised mean ADC by two independent readers. Spondyloarthritis Research Consortium of Canada (SPARCC) spine and sacroiliac (SI) joint MRI indexes were determined. Univariate and multivariate linear regression models were used to determine the associations between of ASDAS with ADC values, SPARCC spine and SI MRI scores.ResultsEighty-two participants had identifiable ADC lesions. Multivariate analyses using ADCmax and SPARCC spine MRI as independent variables showed associations with ASDAS-CRP (ADCmax: B=0.27, p=0.02; SPARCC: B=0.32, p=0.01) and ASDAS-ESR (ADCmax: B=0.24, p=0.03; SPARCC: B=0.36, p<0.01); using ADCmean and SPARCC spine MRI as independent variables also showed an association with ASDAS-ESR (ADCmean: B=0.22, p=0.05; SPARCC: B=0.36, p<0.01) and a tendency to associate with ASDAS-CRP (ADCmean: B=0.21, p=0.07; SPARCC: B=0.34, p<0.01).ConclusionASDAS is associated with both the extent and the intensity of spinal inflammation in patients with detectable inflammatory lesions. Our results showed that ASDAS is an objective disease assessment tool.Trial registration numberHKUCTR-2087.</description><identifier>ISSN: 2056-5933</identifier><identifier>EISSN: 2056-5933</identifier><identifier>DOI: 10.1136/rmdopen-2019-001008</identifier><identifier>PMID: 31452930</identifier><language>eng</language><publisher>England: BMJ Publishing Group LTD</publisher><subject>Arthritis ; Back pain ; Back Pain - diagnosis ; Back Pain - etiology ; Biomarkers ; Bone marrow ; Canada ; Diffusion Magnetic Resonance Imaging - methods ; Female ; Humans ; Image Processing, Computer-Assisted ; Inflammation ; Male ; Middle Aged ; Multivariate Analysis ; NMR ; Nuclear magnetic resonance ; Osteoporosis ; Questionnaires ; Severity of Illness Index ; Spondylarthritis - complications ; Spondylarthritis - diagnosis ; Spondylarthritis - etiology ; Spondylarthritis - metabolism ; Spondyloarthritis ; Systematic review</subject><ispartof>Rheumatic & musculoskeletal diseases open, 2019-08, Vol.5 (2), p.e001008-e001008</ispartof><rights>Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.</rights><rights>2019 Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ . Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b472t-a692312e808a4b418606956ee5c476126dd3d566bbf931c12521e8ad66e045b13</citedby><cites>FETCH-LOGICAL-b472t-a692312e808a4b418606956ee5c476126dd3d566bbf931c12521e8ad66e045b13</cites><orcidid>0000-0002-0175-1346</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://rmdopen.bmj.com/content/5/2/e001008.full.pdf$$EPDF$$P50$$Gbmj$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://rmdopen.bmj.com/content/5/2/e001008.full$$EHTML$$P50$$Gbmj$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27549,27550,27924,27925,53791,53793,77601,77632</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31452930$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chung, Ho Yin</creatorcontrib><creatorcontrib>Chui, Eva Tsz Fung</creatorcontrib><creatorcontrib>Lee, Kam Ho</creatorcontrib><creatorcontrib>Tsang, Helen Hoi Lun</creatorcontrib><creatorcontrib>Chan, Shirley Chiu Wai</creatorcontrib><creatorcontrib>Lau, Chak Sing</creatorcontrib><title>ASDAS is associated with both the extent and intensity of DW-MRI spinal inflammation in active axial spondyloarthritis</title><title>Rheumatic & musculoskeletal diseases open</title><addtitle>RMD Open</addtitle><description>ObjectiveTo investigate the relationship between Ankylosing Spondylitis Disease Activity Score (ASDAS) and intensity of spinal inflammation measured by apparent diffusion coefficient (ADC) in MRI in participants with active axial spondyloarthritis (SpA).MethodsParticipants with axial SpA and back pain were recruited. Clinical, demographic, biochemical and imaging data were collected. ASDAS was calculated based on C reactive protein (CRP) and erythrocyte sedimentation rate (ESR). Inflammatory lesions were identified in short tau inversion recovery images and the corresponding ADC maps to determine the maximum apparent diffusion coefficient (ADCmax), normalised maximum ADC, mean apparent diffusion coefficient (ADCmean) and normalised mean ADC by two independent readers. Spondyloarthritis Research Consortium of Canada (SPARCC) spine and sacroiliac (SI) joint MRI indexes were determined. Univariate and multivariate linear regression models were used to determine the associations between of ASDAS with ADC values, SPARCC spine and SI MRI scores.ResultsEighty-two participants had identifiable ADC lesions. Multivariate analyses using ADCmax and SPARCC spine MRI as independent variables showed associations with ASDAS-CRP (ADCmax: B=0.27, p=0.02; SPARCC: B=0.32, p=0.01) and ASDAS-ESR (ADCmax: B=0.24, p=0.03; SPARCC: B=0.36, p<0.01); using ADCmean and SPARCC spine MRI as independent variables also showed an association with ASDAS-ESR (ADCmean: B=0.22, p=0.05; SPARCC: B=0.36, p<0.01) and a tendency to associate with ASDAS-CRP (ADCmean: B=0.21, p=0.07; SPARCC: B=0.34, p<0.01).ConclusionASDAS is associated with both the extent and the intensity of spinal inflammation in patients with detectable inflammatory lesions. Our results showed that ASDAS is an objective disease assessment tool.Trial registration numberHKUCTR-2087.</description><subject>Arthritis</subject><subject>Back pain</subject><subject>Back Pain - diagnosis</subject><subject>Back Pain - etiology</subject><subject>Biomarkers</subject><subject>Bone marrow</subject><subject>Canada</subject><subject>Diffusion Magnetic Resonance Imaging - methods</subject><subject>Female</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>Inflammation</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Osteoporosis</subject><subject>Questionnaires</subject><subject>Severity of Illness Index</subject><subject>Spondylarthritis - complications</subject><subject>Spondylarthritis - diagnosis</subject><subject>Spondylarthritis - etiology</subject><subject>Spondylarthritis - metabolism</subject><subject>Spondyloarthritis</subject><subject>Systematic review</subject><issn>2056-5933</issn><issn>2056-5933</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>9YT</sourceid><sourceid>ACMMV</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNqNkVFLHDEUhYNYqmz9BQUJ-OLL2Nxkkpl5KSxaW8EiqKWPITPJdLPMJNMku3X_vbG7Fe2TL8kN57uH3HsQ-gjkDICJT2HUfjKuoASaghAgpN5Dh5RwUfCGsf0X9QE6inFJMlQyVgF7jw4YlJw2jByi9fzuYn6HbcQqRt9ZlYzGf2xa4NbnIy0MNg_JuISV09i6XEabNtj3-OJn8f32CsfJOjVkqR_UOKpkvcsPrLpk1warB5vFOHmnN4NXIS2CTTZ-QO96NURztLtn6Mfll_vzb8X1zder8_l10ZYVTYUSDWVATU1qVbYl1IKIhgtjeFdWAqjQmmkuRNv2DYMOKKdgaqWFMKTkLbAZ-rz1nVbtaHSXBwlqkFOwowob6ZWVrxVnF_KXX0shGuB5YTN0ujMI_vfKxCRHGzszDMoZv4qS0hqAVqTiGT35D136Vci7-UvVFQCvaabYluqCjzGY_vkzQORTtHIXrXyKVm6jzV3HL-d47vkXZAbOtkA7Lt_k-AhuJLA5</recordid><startdate>20190801</startdate><enddate>20190801</enddate><creator>Chung, Ho Yin</creator><creator>Chui, Eva Tsz Fung</creator><creator>Lee, Kam Ho</creator><creator>Tsang, Helen Hoi Lun</creator><creator>Chan, Shirley Chiu Wai</creator><creator>Lau, Chak Sing</creator><general>BMJ Publishing Group LTD</general><general>BMJ Publishing Group</general><scope>9YT</scope><scope>ACMMV</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-0175-1346</orcidid></search><sort><creationdate>20190801</creationdate><title>ASDAS is associated with both the extent and intensity of DW-MRI spinal inflammation in active axial spondyloarthritis</title><author>Chung, Ho Yin ; Chui, Eva Tsz Fung ; Lee, Kam Ho ; Tsang, Helen Hoi Lun ; Chan, Shirley Chiu Wai ; Lau, Chak Sing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b472t-a692312e808a4b418606956ee5c476126dd3d566bbf931c12521e8ad66e045b13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Arthritis</topic><topic>Back pain</topic><topic>Back Pain - diagnosis</topic><topic>Back Pain - etiology</topic><topic>Biomarkers</topic><topic>Bone marrow</topic><topic>Canada</topic><topic>Diffusion Magnetic Resonance Imaging - methods</topic><topic>Female</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted</topic><topic>Inflammation</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Osteoporosis</topic><topic>Questionnaires</topic><topic>Severity of Illness Index</topic><topic>Spondylarthritis - complications</topic><topic>Spondylarthritis - diagnosis</topic><topic>Spondylarthritis - etiology</topic><topic>Spondylarthritis - metabolism</topic><topic>Spondyloarthritis</topic><topic>Systematic review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chung, Ho Yin</creatorcontrib><creatorcontrib>Chui, Eva Tsz Fung</creatorcontrib><creatorcontrib>Lee, Kam Ho</creatorcontrib><creatorcontrib>Tsang, Helen Hoi Lun</creatorcontrib><creatorcontrib>Chan, Shirley Chiu Wai</creatorcontrib><creatorcontrib>Lau, Chak Sing</creatorcontrib><collection>BMJ Open Access Journals</collection><collection>BMJ Journals:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Rheumatic & musculoskeletal diseases open</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chung, Ho Yin</au><au>Chui, Eva Tsz Fung</au><au>Lee, Kam Ho</au><au>Tsang, Helen Hoi Lun</au><au>Chan, Shirley Chiu Wai</au><au>Lau, Chak Sing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>ASDAS is associated with both the extent and intensity of DW-MRI spinal inflammation in active axial spondyloarthritis</atitle><jtitle>Rheumatic & musculoskeletal diseases open</jtitle><addtitle>RMD Open</addtitle><date>2019-08-01</date><risdate>2019</risdate><volume>5</volume><issue>2</issue><spage>e001008</spage><epage>e001008</epage><pages>e001008-e001008</pages><issn>2056-5933</issn><eissn>2056-5933</eissn><abstract>ObjectiveTo investigate the relationship between Ankylosing Spondylitis Disease Activity Score (ASDAS) and intensity of spinal inflammation measured by apparent diffusion coefficient (ADC) in MRI in participants with active axial spondyloarthritis (SpA).MethodsParticipants with axial SpA and back pain were recruited. Clinical, demographic, biochemical and imaging data were collected. ASDAS was calculated based on C reactive protein (CRP) and erythrocyte sedimentation rate (ESR). Inflammatory lesions were identified in short tau inversion recovery images and the corresponding ADC maps to determine the maximum apparent diffusion coefficient (ADCmax), normalised maximum ADC, mean apparent diffusion coefficient (ADCmean) and normalised mean ADC by two independent readers. Spondyloarthritis Research Consortium of Canada (SPARCC) spine and sacroiliac (SI) joint MRI indexes were determined. Univariate and multivariate linear regression models were used to determine the associations between of ASDAS with ADC values, SPARCC spine and SI MRI scores.ResultsEighty-two participants had identifiable ADC lesions. Multivariate analyses using ADCmax and SPARCC spine MRI as independent variables showed associations with ASDAS-CRP (ADCmax: B=0.27, p=0.02; SPARCC: B=0.32, p=0.01) and ASDAS-ESR (ADCmax: B=0.24, p=0.03; SPARCC: B=0.36, p<0.01); using ADCmean and SPARCC spine MRI as independent variables also showed an association with ASDAS-ESR (ADCmean: B=0.22, p=0.05; SPARCC: B=0.36, p<0.01) and a tendency to associate with ASDAS-CRP (ADCmean: B=0.21, p=0.07; SPARCC: B=0.34, p<0.01).ConclusionASDAS is associated with both the extent and the intensity of spinal inflammation in patients with detectable inflammatory lesions. Our results showed that ASDAS is an objective disease assessment tool.Trial registration numberHKUCTR-2087.</abstract><cop>England</cop><pub>BMJ Publishing Group LTD</pub><pmid>31452930</pmid><doi>10.1136/rmdopen-2019-001008</doi><orcidid>https://orcid.org/0000-0002-0175-1346</orcidid><oa>free_for_read</oa></addata></record> |
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| source | BMJ Open Access Journals; MEDLINE; DOAJ Directory of Open Access Journals; PubMed Central Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Arthritis Back pain Back Pain - diagnosis Back Pain - etiology Biomarkers Bone marrow Canada Diffusion Magnetic Resonance Imaging - methods Female Humans Image Processing, Computer-Assisted Inflammation Male Middle Aged Multivariate Analysis NMR Nuclear magnetic resonance Osteoporosis Questionnaires Severity of Illness Index Spondylarthritis - complications Spondylarthritis - diagnosis Spondylarthritis - etiology Spondylarthritis - metabolism Spondyloarthritis Systematic review |
| title | ASDAS is associated with both the extent and intensity of DW-MRI spinal inflammation in active axial spondyloarthritis |
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