Psychosis risk is associated with decreased resting-state functional connectivity between the striatum and the default mode network
Psychosis is linked to aberrant salience or to viewing neutral stimuli as self-relevant, suggesting a possible impairment in self-relevance processing. Psychosis is also associated with increased dopamine in the dorsal striatum, especially the anterior caudate (Kegeles et al., 2010 ). Critically, th...
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| Veröffentlicht in: | Cognitive, affective, & behavioral neuroscience affective, & behavioral neuroscience, 2019-08, Vol.19 (4), p.998-1011 |
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| creator | Hua, Jessica P. Y. Karcher, Nicole R. Merrill, Anne M. O’Brien, Kathleen J. Straub, Kelsey T. Trull, Timothy J. Kerns, John G. |
| description | Psychosis is linked to aberrant salience or to viewing neutral stimuli as self-relevant, suggesting a possible impairment in self-relevance processing. Psychosis is also associated with increased dopamine in the dorsal striatum, especially the anterior caudate (Kegeles et al.,
2010
). Critically, the anterior caudate is especially connected to (a) the cortical default mode network (DMN), centrally involved in self-relevance processing, and (b) to a lesser extent, the cortical frontoparietal network (FPN; Choi, Yeo, & Buckner,
2012
). However, no previous study has directly examined striatal–cortical DMN connectivity in psychosis risk. In Study 1, we examined resting-state functional connectivity in psychosis risk (
n
= 18) and control (
n
= 19) groups between (a) striatal DMN and FPN subregions and (b) cortical DMN and FPN. The psychosis risk group exhibited decreased connectivity between the striatal subregions and the cortical DMN. In contrast, the psychosis risk group exhibited intact connectivity between the striatal subregions and the cortical FPN. Additionally, recent distress was also associated with decreased striatal–cortical DMN connectivity. In Study 2, to determine whether the decreased striatal–cortical DMN connectivity was specific to psychosis risk or was related to recent distress more generally, we examined the relationship between connectivity and distress in individuals diagnosed with nonpsychotic emotional distress disorders (
N
= 25). In contrast to Study 1, here we found that distress was associated with evidence of
increased
striatal–cortical DMN connectivity. Overall, the present results suggest that decreased striatal–cortical DMN connectivity is associated with psychosis risk and could contribute to aberrant salience. |
| doi_str_mv | 10.3758/s13415-019-00698-z |
| format | Article |
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2010
). Critically, the anterior caudate is especially connected to (a) the cortical default mode network (DMN), centrally involved in self-relevance processing, and (b) to a lesser extent, the cortical frontoparietal network (FPN; Choi, Yeo, & Buckner,
2012
). However, no previous study has directly examined striatal–cortical DMN connectivity in psychosis risk. In Study 1, we examined resting-state functional connectivity in psychosis risk (
n
= 18) and control (
n
= 19) groups between (a) striatal DMN and FPN subregions and (b) cortical DMN and FPN. The psychosis risk group exhibited decreased connectivity between the striatal subregions and the cortical DMN. In contrast, the psychosis risk group exhibited intact connectivity between the striatal subregions and the cortical FPN. Additionally, recent distress was also associated with decreased striatal–cortical DMN connectivity. In Study 2, to determine whether the decreased striatal–cortical DMN connectivity was specific to psychosis risk or was related to recent distress more generally, we examined the relationship between connectivity and distress in individuals diagnosed with nonpsychotic emotional distress disorders (
N
= 25). In contrast to Study 1, here we found that distress was associated with evidence of
increased
striatal–cortical DMN connectivity. Overall, the present results suggest that decreased striatal–cortical DMN connectivity is associated with psychosis risk and could contribute to aberrant salience.</description><identifier>ISSN: 1530-7026</identifier><identifier>EISSN: 1531-135X</identifier><identifier>DOI: 10.3758/s13415-019-00698-z</identifier><identifier>PMID: 30756347</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Behavioral Science and Psychology ; Brain research ; Caudate-putamen ; Clinical psychology ; Cognition & reasoning ; Cognitive Psychology ; Cortex ; Dopamine ; Medical imaging ; Neostriatum ; Neurophysiology ; Neurosciences ; Psychology ; Psychosis ; Schizophrenia</subject><ispartof>Cognitive, affective, & behavioral neuroscience, 2019-08, Vol.19 (4), p.998-1011</ispartof><rights>The Psychonomic Society, Inc. 2019</rights><rights>Copyright Springer Nature B.V. Aug 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-91820ea42dd37275a5ca98077827a9b976a938df4d68e02c4804f59feda924753</citedby><cites>FETCH-LOGICAL-c474t-91820ea42dd37275a5ca98077827a9b976a938df4d68e02c4804f59feda924753</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.3758/s13415-019-00698-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.3758/s13415-019-00698-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30756347$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hua, Jessica P. Y.</creatorcontrib><creatorcontrib>Karcher, Nicole R.</creatorcontrib><creatorcontrib>Merrill, Anne M.</creatorcontrib><creatorcontrib>O’Brien, Kathleen J.</creatorcontrib><creatorcontrib>Straub, Kelsey T.</creatorcontrib><creatorcontrib>Trull, Timothy J.</creatorcontrib><creatorcontrib>Kerns, John G.</creatorcontrib><title>Psychosis risk is associated with decreased resting-state functional connectivity between the striatum and the default mode network</title><title>Cognitive, affective, & behavioral neuroscience</title><addtitle>Cogn Affect Behav Neurosci</addtitle><addtitle>Cogn Affect Behav Neurosci</addtitle><description>Psychosis is linked to aberrant salience or to viewing neutral stimuli as self-relevant, suggesting a possible impairment in self-relevance processing. Psychosis is also associated with increased dopamine in the dorsal striatum, especially the anterior caudate (Kegeles et al.,
2010
). Critically, the anterior caudate is especially connected to (a) the cortical default mode network (DMN), centrally involved in self-relevance processing, and (b) to a lesser extent, the cortical frontoparietal network (FPN; Choi, Yeo, & Buckner,
2012
). However, no previous study has directly examined striatal–cortical DMN connectivity in psychosis risk. In Study 1, we examined resting-state functional connectivity in psychosis risk (
n
= 18) and control (
n
= 19) groups between (a) striatal DMN and FPN subregions and (b) cortical DMN and FPN. The psychosis risk group exhibited decreased connectivity between the striatal subregions and the cortical DMN. In contrast, the psychosis risk group exhibited intact connectivity between the striatal subregions and the cortical FPN. Additionally, recent distress was also associated with decreased striatal–cortical DMN connectivity. In Study 2, to determine whether the decreased striatal–cortical DMN connectivity was specific to psychosis risk or was related to recent distress more generally, we examined the relationship between connectivity and distress in individuals diagnosed with nonpsychotic emotional distress disorders (
N
= 25). In contrast to Study 1, here we found that distress was associated with evidence of
increased
striatal–cortical DMN connectivity. Overall, the present results suggest that decreased striatal–cortical DMN connectivity is associated with psychosis risk and could contribute to aberrant salience.</description><subject>Behavioral Science and Psychology</subject><subject>Brain research</subject><subject>Caudate-putamen</subject><subject>Clinical psychology</subject><subject>Cognition & reasoning</subject><subject>Cognitive Psychology</subject><subject>Cortex</subject><subject>Dopamine</subject><subject>Medical imaging</subject><subject>Neostriatum</subject><subject>Neurophysiology</subject><subject>Neurosciences</subject><subject>Psychology</subject><subject>Psychosis</subject><subject>Schizophrenia</subject><issn>1530-7026</issn><issn>1531-135X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kT1vFDEQhlcIRD7gD1AgSzQ0C_5c2w0SioAgRYICJDrLZ8_eOdm1g-1NdGn54zh3IXwUVOPxPPOOPW_XPSP4FZNCvS6EcSJ6THSP8aBVf_OgOySCkZ4w8e3h7ox7ielw0B2Vco4x5pTTx90Bw1IMjMvD7sfnsnWbVEJBOZQL1KItJblgK3h0HeoGeXAZbGlphlJDXPeltioal-hqSNFOyKUYoSVXoW7RCuo1QER1A6jU3JSWGdnodxceRrtMFc3JA4qNTPniSfdotFOBp3fxuPv6_t2Xk9P-7NOHjydvz3rHJa-9JopisJx6zySVwgpntcJSKiqtXmk5WM2UH7kfFGDquMJ8FHoEbzXlUrDj7s1e93JZzeAdxJrtZC5zmG3emmSD-bsSw8as05UZBo0V0U3g5Z1ATt-Xtgwzh-JgmmyEtBRDiWpjGBe36It_0PO05LarRjHCMJYDo42ie8rlVEqG8f4xBJtbj83eY9M8NjuPzU1rev7nN-5bfpnaALYHSivFNeTfs_8j-xOr8bZW</recordid><startdate>20190801</startdate><enddate>20190801</enddate><creator>Hua, Jessica P. Y.</creator><creator>Karcher, Nicole R.</creator><creator>Merrill, Anne M.</creator><creator>O’Brien, Kathleen J.</creator><creator>Straub, Kelsey T.</creator><creator>Trull, Timothy J.</creator><creator>Kerns, John G.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>4T-</scope><scope>4U-</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20190801</creationdate><title>Psychosis risk is associated with decreased resting-state functional connectivity between the striatum and the default mode network</title><author>Hua, Jessica P. Y. ; Karcher, Nicole R. ; Merrill, Anne M. ; O’Brien, Kathleen J. ; Straub, Kelsey T. ; Trull, Timothy J. ; Kerns, John G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-91820ea42dd37275a5ca98077827a9b976a938df4d68e02c4804f59feda924753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Behavioral Science and Psychology</topic><topic>Brain research</topic><topic>Caudate-putamen</topic><topic>Clinical psychology</topic><topic>Cognition & reasoning</topic><topic>Cognitive Psychology</topic><topic>Cortex</topic><topic>Dopamine</topic><topic>Medical imaging</topic><topic>Neostriatum</topic><topic>Neurophysiology</topic><topic>Neurosciences</topic><topic>Psychology</topic><topic>Psychosis</topic><topic>Schizophrenia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hua, Jessica P. Y.</creatorcontrib><creatorcontrib>Karcher, Nicole R.</creatorcontrib><creatorcontrib>Merrill, Anne M.</creatorcontrib><creatorcontrib>O’Brien, Kathleen J.</creatorcontrib><creatorcontrib>Straub, Kelsey T.</creatorcontrib><creatorcontrib>Trull, Timothy J.</creatorcontrib><creatorcontrib>Kerns, John G.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Docstoc</collection><collection>University Readers</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cognitive, affective, & behavioral neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hua, Jessica P. Y.</au><au>Karcher, Nicole R.</au><au>Merrill, Anne M.</au><au>O’Brien, Kathleen J.</au><au>Straub, Kelsey T.</au><au>Trull, Timothy J.</au><au>Kerns, John G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Psychosis risk is associated with decreased resting-state functional connectivity between the striatum and the default mode network</atitle><jtitle>Cognitive, affective, & behavioral neuroscience</jtitle><stitle>Cogn Affect Behav Neurosci</stitle><addtitle>Cogn Affect Behav Neurosci</addtitle><date>2019-08-01</date><risdate>2019</risdate><volume>19</volume><issue>4</issue><spage>998</spage><epage>1011</epage><pages>998-1011</pages><issn>1530-7026</issn><eissn>1531-135X</eissn><abstract>Psychosis is linked to aberrant salience or to viewing neutral stimuli as self-relevant, suggesting a possible impairment in self-relevance processing. Psychosis is also associated with increased dopamine in the dorsal striatum, especially the anterior caudate (Kegeles et al.,
2010
). Critically, the anterior caudate is especially connected to (a) the cortical default mode network (DMN), centrally involved in self-relevance processing, and (b) to a lesser extent, the cortical frontoparietal network (FPN; Choi, Yeo, & Buckner,
2012
). However, no previous study has directly examined striatal–cortical DMN connectivity in psychosis risk. In Study 1, we examined resting-state functional connectivity in psychosis risk (
n
= 18) and control (
n
= 19) groups between (a) striatal DMN and FPN subregions and (b) cortical DMN and FPN. The psychosis risk group exhibited decreased connectivity between the striatal subregions and the cortical DMN. In contrast, the psychosis risk group exhibited intact connectivity between the striatal subregions and the cortical FPN. Additionally, recent distress was also associated with decreased striatal–cortical DMN connectivity. In Study 2, to determine whether the decreased striatal–cortical DMN connectivity was specific to psychosis risk or was related to recent distress more generally, we examined the relationship between connectivity and distress in individuals diagnosed with nonpsychotic emotional distress disorders (
N
= 25). In contrast to Study 1, here we found that distress was associated with evidence of
increased
striatal–cortical DMN connectivity. Overall, the present results suggest that decreased striatal–cortical DMN connectivity is associated with psychosis risk and could contribute to aberrant salience.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>30756347</pmid><doi>10.3758/s13415-019-00698-z</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
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| source | Springer Nature - Complete Springer Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Behavioral Science and Psychology Brain research Caudate-putamen Clinical psychology Cognition & reasoning Cognitive Psychology Cortex Dopamine Medical imaging Neostriatum Neurophysiology Neurosciences Psychology Psychosis Schizophrenia |
| title | Psychosis risk is associated with decreased resting-state functional connectivity between the striatum and the default mode network |
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