Porphyrin-lipid assemblies and nanovesicles overcome ABC transporter-mediated photodynamic therapy resistance in cancer cells

Photodynamic therapy (PDT) involves light activation of the photosensitizer to generate reactive molecular species that induce cell modulation or death. Based on earlier findings showing that the photosensitizer benzoporphyrin derivative (BPD) is a breast cancer resistance protein (ABCG2) substrate,...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cancer letters 2019-08, Vol.457, p.110-118
Hauptverfasser:	Baglo, Yan, Liang, Barry J., Robey, Robert W., Ambudkar, Suresh V., Gottesman, Michael M., Huang, Huang-Chiao
Format:	Artikel
Sprache:	eng
Schlagworte:	ABC transporter ABC transporters ATP Binding Cassette Transporter, Subfamily B - genetics ATP Binding Cassette Transporter, Subfamily B - metabolism ATP Binding Cassette Transporter, Subfamily G, Member 2 - genetics ATP Binding Cassette Transporter, Subfamily G, Member 2 - metabolism ATP-binding cassette transporters Benzoporphyrin derivative Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell death Cytotoxicity Drug Compounding Drug Resistance, Neoplasm Flow cytometry Fluorescence Gene Expression Regulation, Enzymologic Glycoproteins Humans Kinases Light Lipids MCF-7 Cells Medical research Multidrug resistance Multidrug Resistance-Associated Proteins - genetics Multidrug Resistance-Associated Proteins - metabolism Multidrug resistant organisms Nanoparticles Neoplasm Proteins - genetics Neoplasm Proteins - metabolism P-Glycoprotein Phospholipids Phospholipids - chemistry Photochemotherapy Photodynamic therapy Photosensitizing Agents - chemistry Photosensitizing Agents - metabolism Photosensitizing Agents - pharmacology Porphyrins - chemistry Porphyrins - metabolism Porphyrins - pharmacology Porphysome nanotechnology Protein transport Proteins Retention Substrates Tumor cell lines Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!