Beppu's Nomogram Score Is an Independent Prognostic Factor for Colorectal Liver Metastasis Receiving Perioperative Chemotherapy and/or Targeted Therapy
We investigated the impact of Beppu's nomogram on colorectal liver metastasis in patients receiving perioperative chemotherapy and/or targeted therapy. This study included 43 patients who underwent primary hepatic resection for colorectal liver metastasis at the Kanagawa Cancer Center from June...
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| Veröffentlicht in: | In vivo (Athens) 2019-07, Vol.33 (4), p.1301-1306 |
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| creator | Higuchi, Akio Aoyama, Toru Kazama, Keisuke Murakawa, Masaaki Atsumi, Yosuke Katayama, Yusuke Numata, Koji Sawazaki, Sho Numata, Masakatsu Sato, Sumito Sugano, Nobuhiro Tamagawa, Hiroshi Mushiake, Hiroyuki Oshima, Takashi Yukawa, Norio Morinaga, Soichiro Rino, Yasushi Masuda, Munetaka Shiozawa, Manabu |
| description | We investigated the impact of Beppu's nomogram on colorectal liver metastasis in patients receiving perioperative chemotherapy and/or targeted therapy.
This study included 43 patients who underwent primary hepatic resection for colorectal liver metastasis at the Kanagawa Cancer Center from June 2006 to March 2011. The patients were classified as having a Beppu's nomogram score ≤9 (low-risk group) or ≥10 (high-risk group). The risk factors for the disease-free survival (DFS) were identified.
The respective DFS rates at 1, 2, and 3 years after surgery were 72.0%, 43.3%, and 17.3% in the low-risk group and 27.8%, 16.7%, and 8.3% in the high-risk group, the difference being significant (p=0.009). The multivariate analysis showed that Beppu's nomogram score ≥10 was a significant independent risk factor for the DFS.
Beppu's nomogram score was an independent prognostic factor for colorectal liver metastasis in patients receiving perioperative chemotherapy and/or targeted therapy. Thus, Beppu's nomogram might be a useful tool for predicting the risk of recurrence after hepatectomy, even in the era of newly-developed chemotherapy. |
| doi_str_mv | 10.21873/invivo.11603 |
| format | Article |
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This study included 43 patients who underwent primary hepatic resection for colorectal liver metastasis at the Kanagawa Cancer Center from June 2006 to March 2011. The patients were classified as having a Beppu's nomogram score ≤9 (low-risk group) or ≥10 (high-risk group). The risk factors for the disease-free survival (DFS) were identified.
The respective DFS rates at 1, 2, and 3 years after surgery were 72.0%, 43.3%, and 17.3% in the low-risk group and 27.8%, 16.7%, and 8.3% in the high-risk group, the difference being significant (p=0.009). The multivariate analysis showed that Beppu's nomogram score ≥10 was a significant independent risk factor for the DFS.
Beppu's nomogram score was an independent prognostic factor for colorectal liver metastasis in patients receiving perioperative chemotherapy and/or targeted therapy. Thus, Beppu's nomogram might be a useful tool for predicting the risk of recurrence after hepatectomy, even in the era of newly-developed chemotherapy.</description><identifier>ISSN: 0258-851X</identifier><identifier>ISSN: 1791-7549</identifier><identifier>EISSN: 1791-7549</identifier><identifier>DOI: 10.21873/invivo.11603</identifier><identifier>PMID: 31280222</identifier><language>eng</language><publisher>Greece: International Institute of Anticancer Research</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Chemotherapy, Adjuvant - adverse effects ; Chemotherapy, Adjuvant - methods ; Colorectal Neoplasms - pathology ; Combined Modality Therapy ; Disease-Free Survival ; Female ; Humans ; Liver Neoplasms - diagnosis ; Liver Neoplasms - mortality ; Liver Neoplasms - secondary ; Liver Neoplasms - therapy ; Male ; Middle Aged ; Molecular Targeted Therapy ; Neoplasm Staging ; Nomograms ; Perioperative Care ; Treatment Outcome</subject><ispartof>In vivo (Athens), 2019-07, Vol.33 (4), p.1301-1306</ispartof><rights>Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.</rights><rights>Copyright 2019, International Institute of Anticancer Research 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c453t-e63d50ee62d61ec4e7361678b664091ad95868b5abf381991eb7850c8ab7ea1c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689347/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689347/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53770,53772</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31280222$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Higuchi, Akio</creatorcontrib><creatorcontrib>Aoyama, Toru</creatorcontrib><creatorcontrib>Kazama, Keisuke</creatorcontrib><creatorcontrib>Murakawa, Masaaki</creatorcontrib><creatorcontrib>Atsumi, Yosuke</creatorcontrib><creatorcontrib>Katayama, Yusuke</creatorcontrib><creatorcontrib>Numata, Koji</creatorcontrib><creatorcontrib>Sawazaki, Sho</creatorcontrib><creatorcontrib>Numata, Masakatsu</creatorcontrib><creatorcontrib>Sato, Sumito</creatorcontrib><creatorcontrib>Sugano, Nobuhiro</creatorcontrib><creatorcontrib>Tamagawa, Hiroshi</creatorcontrib><creatorcontrib>Mushiake, Hiroyuki</creatorcontrib><creatorcontrib>Oshima, Takashi</creatorcontrib><creatorcontrib>Yukawa, Norio</creatorcontrib><creatorcontrib>Morinaga, Soichiro</creatorcontrib><creatorcontrib>Rino, Yasushi</creatorcontrib><creatorcontrib>Masuda, Munetaka</creatorcontrib><creatorcontrib>Shiozawa, Manabu</creatorcontrib><title>Beppu's Nomogram Score Is an Independent Prognostic Factor for Colorectal Liver Metastasis Receiving Perioperative Chemotherapy and/or Targeted Therapy</title><title>In vivo (Athens)</title><addtitle>In Vivo</addtitle><description>We investigated the impact of Beppu's nomogram on colorectal liver metastasis in patients receiving perioperative chemotherapy and/or targeted therapy.
This study included 43 patients who underwent primary hepatic resection for colorectal liver metastasis at the Kanagawa Cancer Center from June 2006 to March 2011. The patients were classified as having a Beppu's nomogram score ≤9 (low-risk group) or ≥10 (high-risk group). The risk factors for the disease-free survival (DFS) were identified.
The respective DFS rates at 1, 2, and 3 years after surgery were 72.0%, 43.3%, and 17.3% in the low-risk group and 27.8%, 16.7%, and 8.3% in the high-risk group, the difference being significant (p=0.009). The multivariate analysis showed that Beppu's nomogram score ≥10 was a significant independent risk factor for the DFS.
Beppu's nomogram score was an independent prognostic factor for colorectal liver metastasis in patients receiving perioperative chemotherapy and/or targeted therapy. Thus, Beppu's nomogram might be a useful tool for predicting the risk of recurrence after hepatectomy, even in the era of newly-developed chemotherapy.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Chemotherapy, Adjuvant - adverse effects</subject><subject>Chemotherapy, Adjuvant - methods</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Combined Modality Therapy</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Humans</subject><subject>Liver Neoplasms - diagnosis</subject><subject>Liver Neoplasms - mortality</subject><subject>Liver Neoplasms - secondary</subject><subject>Liver Neoplasms - therapy</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Molecular Targeted Therapy</subject><subject>Neoplasm Staging</subject><subject>Nomograms</subject><subject>Perioperative Care</subject><subject>Treatment Outcome</subject><issn>0258-851X</issn><issn>1791-7549</issn><issn>1791-7549</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkU1v1DAQhi0Eosu2R67IN7ik9UdiOxckWNF2pQUq2ErcLMeZzRolcWp7I_WX8HdrdUsF0nhGnnn0jq0XobeUnDOqJL9w4-xmf06pIPwFWlBZ00JWZf0SLQirVKEq-usEvYnxNyFCEsJeoxNOmSKMsQX68xmm6fA-4m9-8F0wA_5pfQC8jtiMeD22MEFOY8I3wXejj8lZfGls8gHv8ln5PuM2mR5v3AwBf4VkYg4X8Q-w4GY3dvgGgvMTBJMyg1d7GHza5-t0n7e0F1lna0IHCVq8PfZP0aud6SOcPdUlur38sl1dF5vvV-vVp01hy4qnAgRvKwIgWCso2BIkF1RI1QhRkpqatq6UUE1lmh1XtK4pNFJVxCrTSDDU8iX6eNSdDs0Arc0_DabXU3CDCffaG6f_n4xurzs_ayFUzUuZBT48CQR_d4CY9OCihb43I_hD1IxVXHHOc1mi4oja4GMMsHteQ4l-NFMfzdSPZmb-3b9ve6b_uscfANNCoEg</recordid><startdate>20190701</startdate><enddate>20190701</enddate><creator>Higuchi, Akio</creator><creator>Aoyama, Toru</creator><creator>Kazama, Keisuke</creator><creator>Murakawa, Masaaki</creator><creator>Atsumi, Yosuke</creator><creator>Katayama, Yusuke</creator><creator>Numata, Koji</creator><creator>Sawazaki, Sho</creator><creator>Numata, Masakatsu</creator><creator>Sato, Sumito</creator><creator>Sugano, Nobuhiro</creator><creator>Tamagawa, Hiroshi</creator><creator>Mushiake, Hiroyuki</creator><creator>Oshima, Takashi</creator><creator>Yukawa, Norio</creator><creator>Morinaga, Soichiro</creator><creator>Rino, Yasushi</creator><creator>Masuda, Munetaka</creator><creator>Shiozawa, Manabu</creator><general>International Institute of Anticancer Research</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20190701</creationdate><title>Beppu's Nomogram Score Is an Independent Prognostic Factor for Colorectal Liver Metastasis Receiving Perioperative Chemotherapy and/or Targeted Therapy</title><author>Higuchi, Akio ; Aoyama, Toru ; Kazama, Keisuke ; Murakawa, Masaaki ; Atsumi, Yosuke ; Katayama, Yusuke ; Numata, Koji ; Sawazaki, Sho ; Numata, Masakatsu ; Sato, Sumito ; Sugano, Nobuhiro ; Tamagawa, Hiroshi ; Mushiake, Hiroyuki ; Oshima, Takashi ; Yukawa, Norio ; Morinaga, Soichiro ; Rino, Yasushi ; Masuda, Munetaka ; Shiozawa, Manabu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c453t-e63d50ee62d61ec4e7361678b664091ad95868b5abf381991eb7850c8ab7ea1c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Chemotherapy, Adjuvant - adverse effects</topic><topic>Chemotherapy, Adjuvant - methods</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Combined Modality Therapy</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Humans</topic><topic>Liver Neoplasms - diagnosis</topic><topic>Liver Neoplasms - mortality</topic><topic>Liver Neoplasms - secondary</topic><topic>Liver Neoplasms - therapy</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Molecular Targeted Therapy</topic><topic>Neoplasm Staging</topic><topic>Nomograms</topic><topic>Perioperative Care</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Higuchi, Akio</creatorcontrib><creatorcontrib>Aoyama, Toru</creatorcontrib><creatorcontrib>Kazama, Keisuke</creatorcontrib><creatorcontrib>Murakawa, Masaaki</creatorcontrib><creatorcontrib>Atsumi, Yosuke</creatorcontrib><creatorcontrib>Katayama, Yusuke</creatorcontrib><creatorcontrib>Numata, Koji</creatorcontrib><creatorcontrib>Sawazaki, Sho</creatorcontrib><creatorcontrib>Numata, Masakatsu</creatorcontrib><creatorcontrib>Sato, Sumito</creatorcontrib><creatorcontrib>Sugano, Nobuhiro</creatorcontrib><creatorcontrib>Tamagawa, Hiroshi</creatorcontrib><creatorcontrib>Mushiake, Hiroyuki</creatorcontrib><creatorcontrib>Oshima, Takashi</creatorcontrib><creatorcontrib>Yukawa, Norio</creatorcontrib><creatorcontrib>Morinaga, Soichiro</creatorcontrib><creatorcontrib>Rino, Yasushi</creatorcontrib><creatorcontrib>Masuda, Munetaka</creatorcontrib><creatorcontrib>Shiozawa, Manabu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>In vivo (Athens)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Higuchi, Akio</au><au>Aoyama, Toru</au><au>Kazama, Keisuke</au><au>Murakawa, Masaaki</au><au>Atsumi, Yosuke</au><au>Katayama, Yusuke</au><au>Numata, Koji</au><au>Sawazaki, Sho</au><au>Numata, Masakatsu</au><au>Sato, Sumito</au><au>Sugano, Nobuhiro</au><au>Tamagawa, Hiroshi</au><au>Mushiake, Hiroyuki</au><au>Oshima, Takashi</au><au>Yukawa, Norio</au><au>Morinaga, Soichiro</au><au>Rino, Yasushi</au><au>Masuda, Munetaka</au><au>Shiozawa, Manabu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Beppu's Nomogram Score Is an Independent Prognostic Factor for Colorectal Liver Metastasis Receiving Perioperative Chemotherapy and/or Targeted Therapy</atitle><jtitle>In vivo (Athens)</jtitle><addtitle>In Vivo</addtitle><date>2019-07-01</date><risdate>2019</risdate><volume>33</volume><issue>4</issue><spage>1301</spage><epage>1306</epage><pages>1301-1306</pages><issn>0258-851X</issn><issn>1791-7549</issn><eissn>1791-7549</eissn><abstract>We investigated the impact of Beppu's nomogram on colorectal liver metastasis in patients receiving perioperative chemotherapy and/or targeted therapy.
This study included 43 patients who underwent primary hepatic resection for colorectal liver metastasis at the Kanagawa Cancer Center from June 2006 to March 2011. The patients were classified as having a Beppu's nomogram score ≤9 (low-risk group) or ≥10 (high-risk group). The risk factors for the disease-free survival (DFS) were identified.
The respective DFS rates at 1, 2, and 3 years after surgery were 72.0%, 43.3%, and 17.3% in the low-risk group and 27.8%, 16.7%, and 8.3% in the high-risk group, the difference being significant (p=0.009). The multivariate analysis showed that Beppu's nomogram score ≥10 was a significant independent risk factor for the DFS.
Beppu's nomogram score was an independent prognostic factor for colorectal liver metastasis in patients receiving perioperative chemotherapy and/or targeted therapy. Thus, Beppu's nomogram might be a useful tool for predicting the risk of recurrence after hepatectomy, even in the era of newly-developed chemotherapy.</abstract><cop>Greece</cop><pub>International Institute of Anticancer Research</pub><pmid>31280222</pmid><doi>10.21873/invivo.11603</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | In vivo (Athens), 2019-07, Vol.33 (4), p.1301-1306 |
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| subjects | Adult Aged Aged, 80 and over Chemotherapy, Adjuvant - adverse effects Chemotherapy, Adjuvant - methods Colorectal Neoplasms - pathology Combined Modality Therapy Disease-Free Survival Female Humans Liver Neoplasms - diagnosis Liver Neoplasms - mortality Liver Neoplasms - secondary Liver Neoplasms - therapy Male Middle Aged Molecular Targeted Therapy Neoplasm Staging Nomograms Perioperative Care Treatment Outcome |
| title | Beppu's Nomogram Score Is an Independent Prognostic Factor for Colorectal Liver Metastasis Receiving Perioperative Chemotherapy and/or Targeted Therapy |
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