A Two-Component System That Modulates Cyclic di-GMP Metabolism Promotes Legionella pneumophila Differentiation and Viability in Low-Nutrient Conditions

During its life cycle, the environmental pathogen alternates between a replicative and transmissive cell type when cultured in broth, macrophages, or amoebae. Within a protozoan host, further differentiates into the hardy cell type known as the mature infectious form (MIF). The second messenger cycl...

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