Functional Ontogeny of Hypothalamic Agrp Neurons in Neonatal Mouse Behaviors

Hypothalamic Agrp neurons regulate food ingestion in adult mice. Whether these neurons are functional before animals start to ingest food is unknown. Here, we studied the functional ontogeny of Agrp neurons during breastfeeding using postnatal day 10 mice. In contrast to adult mice, we show that iso...

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Veröffentlicht in:	Cell 2019-06, Vol.178 (1), p.44-59.e7
Hauptverfasser:	Zimmer, Marcelo R., Fonseca, Antonio H.O., Iyilikci, Onur, Pra, Rafael Dai, Dietrich, Marcelo O.
Format:	Artikel
Sprache:	eng
Schlagworte:	Agouti-Related Protein - genetics Agouti-Related Protein - metabolism Agrp neurons Animals Animals, Newborn Eating - physiology Feeding Behavior - physiology foster dam gamma-Aminobutyric Acid - metabolism Hypothalamus - cytology Maternal Behavior - physiology maternal care Mice Mice, Knockout Milk neonatal behaviors nest isolation Neurons - metabolism Proto-Oncogene Proteins c-fos - metabolism Social Isolation Sucking Behavior - physiology suckling behavior Temperature thermoneutrality ultrasonic vocalizations Vocalization, Animal - physiology
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