Patterns of Early p21 Dynamics Determine Proliferation-Senescence Cell Fate after Chemotherapy

Chemotherapy is designed to induce cell death. However, at non-lethal doses, cancer cells can choose to remain proliferative or become senescent. The slow development of senescence makes studying this decision challenging. Here, by analyzing single-cell p21 dynamics before, during, and days after dr...

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Veröffentlicht in:	Cell 2019-07, Vol.178 (2), p.361-373.e12
Hauptverfasser:	Hsu, Chien-Hsiang, Altschuler, Steven J., Wu, Lani F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Cycle Checkpoints - drug effects cell death Cell Line, Tumor cell proliferation Cell Proliferation - drug effects cell tracking cell-fate decision Cellular Senescence - drug effects Checkpoint Kinase 1 - metabolism Cyclin-Dependent Kinase Inhibitor p21 - antagonists & inhibitors Cyclin-Dependent Kinase Inhibitor p21 - genetics Cyclin-Dependent Kinase Inhibitor p21 - metabolism DNA Damage - drug effects Doxorubicin - pharmacology drug therapy Humans Models, Biological neoplasm cells p21 RNA Interference RNA, Small Interfering - metabolism senescence Tumor Suppressor Protein p53 - metabolism
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