Differentiation of human adipose-derived stem cells into neuron/motoneuron-like cells for cell replacement therapy of spinal cord injury

Human adipose-derived stem cells (hADSCs) are increasingly presumed to be a prospective stem cell source for cell replacement therapy in various degenerative and/or traumatic diseases. The potential of trans-differentiating hADSCs into motor neuron cells indisputably provides an alternative way for...

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Veröffentlicht in:	Cell death & disease 2019-08, Vol.10 (8), p.597-15, Article 597
Hauptverfasser:	Gao, Shane, Guo, Xuanxuan, Zhao, Simeng, Jin, Yinpeng, Zhou, Fei, Yuan, Ping, Cao, Limei, Wang, Jian, Qiu, Yue, Sun, Chenxi, Kang, Zhanrong, Gao, Fengjuan, Xu, Wei, Hu, Xiao, Yang, Danjing, Qin, Ying, Ning, Ke, Shaw, Pamela J., Zhong, Guisheng, Cheng, Liming, Zhu, Hongwen, Gao, Zhengliang, Chen, Xu, Xu, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	13/100 13/107 13/109 13/51 631/136/368 692/308/2171 82 82/1 Animals Antibodies Biochemistry Biomedical and Life Sciences Brain slice preparation Cell Biology Cell Culture Cell differentiation Cell Differentiation - drug effects Cell Transdifferentiation - drug effects Chemokines Cytokines Disease Models, Animal Ganciclovir Hedgehog protein Hedgehog Proteins - genetics Humans Immunology Immunosuppression Inflammation Life Sciences Mesenchymal Stem Cell Transplantation Mesenchymal Stem Cells - cytology Mesenchymal Stem Cells - drug effects Mice Motor evoked potentials Motor Neurons - drug effects Motor Neurons - transplantation Nerve Growth Factors - genetics Neural networks Neurotrophic factors Recovery of function Retinoic acid Spinal cord injuries Spinal Cord Injuries - genetics Spinal Cord Injuries - pathology Spinal Cord Injuries - therapy Stem cell transplantation Stem cells Tretinoin - pharmacology
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