Candidalysin: discovery and function in Candida albicans infections
•Candidalysin is the first peptide toxin identified in any human fungal pathogen.•Candidalysin is critical for Candida albicans mucosal and systemic infections.•Candidalysin activates danger-response and damage-protection pathways in host cells.•Candidalysin activates the epidermal growth factor rec...
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| Veröffentlicht in: | Current opinion in microbiology 2019-12, Vol.52, p.100-109 |
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| container_title | Current opinion in microbiology |
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| creator | Naglik, Julian R Gaffen, Sarah L Hube, Bernhard |
| description | •Candidalysin is the first peptide toxin identified in any human fungal pathogen.•Candidalysin is critical for Candida albicans mucosal and systemic infections.•Candidalysin activates danger-response and damage-protection pathways in host cells.•Candidalysin activates the epidermal growth factor receptor in epithelial cells and the NLRP3 inflammasome in macrophages.•Candidalysin drives neutrophil recruitment and Type 17 immunity.
Candidalysin is a cytolytic peptide toxin secreted by the invasive form of the human pathogenic fungus, Candida albicans. Candidalysin is critical for mucosal and systemic infections and is a key driver of host cell activation, neutrophil recruitment and Type 17 immunity. Candidalysin is regarded as the first true classical virulence factor of C. albicans but also triggers protective immune responses. This review will discuss how candidalysin was discovered, the mechanisms by which this peptide toxin contributes to C. albicans infections, and how its discovery has advanced our understanding of fungal pathogenesis and disease. |
| doi_str_mv | 10.1016/j.mib.2019.06.002 |
| format | Article |
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Candidalysin is a cytolytic peptide toxin secreted by the invasive form of the human pathogenic fungus, Candida albicans. Candidalysin is critical for mucosal and systemic infections and is a key driver of host cell activation, neutrophil recruitment and Type 17 immunity. Candidalysin is regarded as the first true classical virulence factor of C. albicans but also triggers protective immune responses. This review will discuss how candidalysin was discovered, the mechanisms by which this peptide toxin contributes to C. albicans infections, and how its discovery has advanced our understanding of fungal pathogenesis and disease.</description><identifier>ISSN: 1369-5274</identifier><identifier>EISSN: 1879-0364</identifier><identifier>DOI: 10.1016/j.mib.2019.06.002</identifier><identifier>PMID: 31288097</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Candida albicans - metabolism ; Candidiasis - microbiology ; Candidiasis - physiopathology ; Fungal Proteins - immunology ; Fungal Proteins - metabolism ; Host-Pathogen Interactions ; Humans ; Mycotoxins - immunology ; Mycotoxins - metabolism ; Virulence Factors - immunology ; Virulence Factors - metabolism</subject><ispartof>Current opinion in microbiology, 2019-12, Vol.52, p.100-109</ispartof><rights>2019 The Authors</rights><rights>Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.</rights><rights>2019 The Authors 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c517t-48bffc8b2722b4c81ec34190af68077fd9f5e41f59ea2b4e73013061691015b63</citedby><cites>FETCH-LOGICAL-c517t-48bffc8b2722b4c81ec34190af68077fd9f5e41f59ea2b4e73013061691015b63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.mib.2019.06.002$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31288097$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Naglik, Julian R</creatorcontrib><creatorcontrib>Gaffen, Sarah L</creatorcontrib><creatorcontrib>Hube, Bernhard</creatorcontrib><title>Candidalysin: discovery and function in Candida albicans infections</title><title>Current opinion in microbiology</title><addtitle>Curr Opin Microbiol</addtitle><description>•Candidalysin is the first peptide toxin identified in any human fungal pathogen.•Candidalysin is critical for Candida albicans mucosal and systemic infections.•Candidalysin activates danger-response and damage-protection pathways in host cells.•Candidalysin activates the epidermal growth factor receptor in epithelial cells and the NLRP3 inflammasome in macrophages.•Candidalysin drives neutrophil recruitment and Type 17 immunity.
Candidalysin is a cytolytic peptide toxin secreted by the invasive form of the human pathogenic fungus, Candida albicans. Candidalysin is critical for mucosal and systemic infections and is a key driver of host cell activation, neutrophil recruitment and Type 17 immunity. Candidalysin is regarded as the first true classical virulence factor of C. albicans but also triggers protective immune responses. This review will discuss how candidalysin was discovered, the mechanisms by which this peptide toxin contributes to C. albicans infections, and how its discovery has advanced our understanding of fungal pathogenesis and disease.</description><subject>Animals</subject><subject>Candida albicans - metabolism</subject><subject>Candidiasis - microbiology</subject><subject>Candidiasis - physiopathology</subject><subject>Fungal Proteins - immunology</subject><subject>Fungal Proteins - metabolism</subject><subject>Host-Pathogen Interactions</subject><subject>Humans</subject><subject>Mycotoxins - immunology</subject><subject>Mycotoxins - metabolism</subject><subject>Virulence Factors - immunology</subject><subject>Virulence Factors - metabolism</subject><issn>1369-5274</issn><issn>1879-0364</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kN1KAzEQhYMotlYfwBvZF9h1stnNj4Igi39Q8EavQzabaMo2W5K20Lc3tbXojVczzJxzhvkQusRQYMD0elbMXVuUgEUBtAAoj9AYcyZyILQ6Tj2hIq9LVo3QWYwzAKhETU_RiOCScxBsjJpG-c51qt9E52-yzkU9rE3YZGmc2ZXXSzf4zPlsr8tU3zqtfEwza7638RydWNVHc7GvE_T--PDWPOfT16eX5n6a6xqzZV7x1lrN25KVZVtpjo0mFRagLOXAmO2ErU2FbS2MSgLDCGACFFORnq1bSibobpe7WLVz02njl0H1chHcXIWNHJSTfzfefcqPYS0p5awGkgLwLkCHIcZg7MGLQW6JyplMROWWqAQqE9Hkufp99OD4QZgEtzuBSa-vnQkyame8Np0LCZDsBvdP_BfTr4e4</recordid><startdate>201912</startdate><enddate>201912</enddate><creator>Naglik, Julian R</creator><creator>Gaffen, Sarah L</creator><creator>Hube, Bernhard</creator><general>Elsevier Ltd</general><general>Current Biology</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>201912</creationdate><title>Candidalysin: discovery and function in Candida albicans infections</title><author>Naglik, Julian R ; Gaffen, Sarah L ; Hube, Bernhard</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c517t-48bffc8b2722b4c81ec34190af68077fd9f5e41f59ea2b4e73013061691015b63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Animals</topic><topic>Candida albicans - metabolism</topic><topic>Candidiasis - microbiology</topic><topic>Candidiasis - physiopathology</topic><topic>Fungal Proteins - immunology</topic><topic>Fungal Proteins - metabolism</topic><topic>Host-Pathogen Interactions</topic><topic>Humans</topic><topic>Mycotoxins - immunology</topic><topic>Mycotoxins - metabolism</topic><topic>Virulence Factors - immunology</topic><topic>Virulence Factors - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Naglik, Julian R</creatorcontrib><creatorcontrib>Gaffen, Sarah L</creatorcontrib><creatorcontrib>Hube, Bernhard</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Current opinion in microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Naglik, Julian R</au><au>Gaffen, Sarah L</au><au>Hube, Bernhard</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Candidalysin: discovery and function in Candida albicans infections</atitle><jtitle>Current opinion in microbiology</jtitle><addtitle>Curr Opin Microbiol</addtitle><date>2019-12</date><risdate>2019</risdate><volume>52</volume><spage>100</spage><epage>109</epage><pages>100-109</pages><issn>1369-5274</issn><eissn>1879-0364</eissn><abstract>•Candidalysin is the first peptide toxin identified in any human fungal pathogen.•Candidalysin is critical for Candida albicans mucosal and systemic infections.•Candidalysin activates danger-response and damage-protection pathways in host cells.•Candidalysin activates the epidermal growth factor receptor in epithelial cells and the NLRP3 inflammasome in macrophages.•Candidalysin drives neutrophil recruitment and Type 17 immunity.
Candidalysin is a cytolytic peptide toxin secreted by the invasive form of the human pathogenic fungus, Candida albicans. Candidalysin is critical for mucosal and systemic infections and is a key driver of host cell activation, neutrophil recruitment and Type 17 immunity. Candidalysin is regarded as the first true classical virulence factor of C. albicans but also triggers protective immune responses. This review will discuss how candidalysin was discovered, the mechanisms by which this peptide toxin contributes to C. albicans infections, and how its discovery has advanced our understanding of fungal pathogenesis and disease.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>31288097</pmid><doi>10.1016/j.mib.2019.06.002</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Current opinion in microbiology, 2019-12, Vol.52, p.100-109 |
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| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Candida albicans - metabolism Candidiasis - microbiology Candidiasis - physiopathology Fungal Proteins - immunology Fungal Proteins - metabolism Host-Pathogen Interactions Humans Mycotoxins - immunology Mycotoxins - metabolism Virulence Factors - immunology Virulence Factors - metabolism |
| title | Candidalysin: discovery and function in Candida albicans infections |
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