Serum Ferritin Levels: A Potential Biomarker to Represent Child-Turcotte-Pugh Score among Decompensated Liver Cirrhosis Patients
Liver cirrhosis and the child-Turcotte-Pugh (CTP) score are inseparable entities in liver disease. CTP score is largely known as the mortality and prognosis predictor. Nevertheless, ferritin emerges as a simple biomarker related to prognosis. The study aimed to determine whether there was a signific...
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| Veröffentlicht in: | The Malaysian journal of medical sciences 2019-03, Vol.26 (2), p.59-65 |
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| creator | Sungkar, Taufik Rozi, Muhammad Fakhrur Dairi, Leo Basa Zain, Lukman Hakim |
| description | Liver cirrhosis and the child-Turcotte-Pugh (CTP) score are inseparable entities in liver disease. CTP score is largely known as the mortality and prognosis predictor. Nevertheless, ferritin emerges as a simple biomarker related to prognosis. The study aimed to determine whether there was a significant correlation between serum ferritin levels and CTP score.
The study analysed 54 decompensated liver cirrhotic patients including 17 females and 37 males between May 2016 and May 2017 at the Haji Adam Malik General Hospital, Medan, Indonesia. Ferritin levels were, then, divided into trichotomous cut-off value (< 200 ng/mL,
= 22; 200-400 ng/mL,
= 5; and > 400 ng/mL,
= 27). Data was analysed using SPSS version 12.0 (continuous variables were assessed by the Kruskal-Wallis test and Chi-square test was used for categorical variables). In addition, Spearman correlation test was used to determine any significant correlation between ferritin levels and CTP score.
Based on data analysis, gender and CTP score were related to higher ferritin levels (
= 0.002 and
= 0.018, respectively). Furthermore, a significant correlation between serum ferritin levels and CTP score was obtained in to moderate degree (
= 0.000;
= 0.487).
There might be a significant role of serum ferritin levels in predicting mortality and prognosis among decompensated liver cirrhosis patients but it still needs further attention. |
| doi_str_mv | 10.21315/mjms2019.26.2.7 |
| format | Article |
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The study analysed 54 decompensated liver cirrhotic patients including 17 females and 37 males between May 2016 and May 2017 at the Haji Adam Malik General Hospital, Medan, Indonesia. Ferritin levels were, then, divided into trichotomous cut-off value (< 200 ng/mL,
= 22; 200-400 ng/mL,
= 5; and > 400 ng/mL,
= 27). Data was analysed using SPSS version 12.0 (continuous variables were assessed by the Kruskal-Wallis test and Chi-square test was used for categorical variables). In addition, Spearman correlation test was used to determine any significant correlation between ferritin levels and CTP score.
Based on data analysis, gender and CTP score were related to higher ferritin levels (
= 0.002 and
= 0.018, respectively). Furthermore, a significant correlation between serum ferritin levels and CTP score was obtained in to moderate degree (
= 0.000;
= 0.487).
There might be a significant role of serum ferritin levels in predicting mortality and prognosis among decompensated liver cirrhosis patients but it still needs further attention.</description><identifier>ISSN: 1394-195X</identifier><identifier>EISSN: 2180-4303</identifier><identifier>DOI: 10.21315/mjms2019.26.2.7</identifier><identifier>PMID: 31447609</identifier><language>eng</language><publisher>Malaysia: Universiti Sains Malaysia Press</publisher><subject>Ascites ; Biomarkers ; Esophagus ; Hepatitis B ; Hospitals ; Infections ; Inflammation ; Laboratories ; Liver cirrhosis ; Liver diseases ; Males ; Malik, Adam ; Medical records ; Medical research ; Mortality ; Original ; Patients ; Viral infections</subject><ispartof>The Malaysian journal of medical sciences, 2019-03, Vol.26 (2), p.59-65</ispartof><rights>Copyright Universiti Sains Malaysia Press Mar/Apr 2019</rights><rights>Penerbit Universiti Sains Malaysia, 2019 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c424t-560dabb08573bea0ce4d8c1a0c0672c4f181b936eba653d424d07db1c504beb03</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6687222/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6687222/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31447609$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sungkar, Taufik</creatorcontrib><creatorcontrib>Rozi, Muhammad Fakhrur</creatorcontrib><creatorcontrib>Dairi, Leo Basa</creatorcontrib><creatorcontrib>Zain, Lukman Hakim</creatorcontrib><creatorcontrib>Department of Internal Medicine, Gastroenterology-Hepatology Division, Universitas Sumatera Utara, Padang Bulan, Medan, Indonesia</creatorcontrib><creatorcontrib>Faculty of Medicine, Universitas Sumatera Utara, Padang Bulan, Medan, Indonesia</creatorcontrib><title>Serum Ferritin Levels: A Potential Biomarker to Represent Child-Turcotte-Pugh Score among Decompensated Liver Cirrhosis Patients</title><title>The Malaysian journal of medical sciences</title><addtitle>Malays J Med Sci</addtitle><description>Liver cirrhosis and the child-Turcotte-Pugh (CTP) score are inseparable entities in liver disease. CTP score is largely known as the mortality and prognosis predictor. Nevertheless, ferritin emerges as a simple biomarker related to prognosis. The study aimed to determine whether there was a significant correlation between serum ferritin levels and CTP score.
The study analysed 54 decompensated liver cirrhotic patients including 17 females and 37 males between May 2016 and May 2017 at the Haji Adam Malik General Hospital, Medan, Indonesia. Ferritin levels were, then, divided into trichotomous cut-off value (< 200 ng/mL,
= 22; 200-400 ng/mL,
= 5; and > 400 ng/mL,
= 27). Data was analysed using SPSS version 12.0 (continuous variables were assessed by the Kruskal-Wallis test and Chi-square test was used for categorical variables). In addition, Spearman correlation test was used to determine any significant correlation between ferritin levels and CTP score.
Based on data analysis, gender and CTP score were related to higher ferritin levels (
= 0.002 and
= 0.018, respectively). Furthermore, a significant correlation between serum ferritin levels and CTP score was obtained in to moderate degree (
= 0.000;
= 0.487).
There might be a significant role of serum ferritin levels in predicting mortality and prognosis among decompensated liver cirrhosis patients but it still needs further attention.</description><subject>Ascites</subject><subject>Biomarkers</subject><subject>Esophagus</subject><subject>Hepatitis B</subject><subject>Hospitals</subject><subject>Infections</subject><subject>Inflammation</subject><subject>Laboratories</subject><subject>Liver cirrhosis</subject><subject>Liver diseases</subject><subject>Males</subject><subject>Malik, Adam</subject><subject>Medical records</subject><subject>Medical research</subject><subject>Mortality</subject><subject>Original</subject><subject>Patients</subject><subject>Viral infections</subject><issn>1394-195X</issn><issn>2180-4303</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpdkUtvEzEUhS1ERdPCnhWyxKabCX6PhwVSSSlUikREi8TO8nhuEoeZcbA9kbrjp2PoQ8DKlu45371HB6GXlMwZ5VS-GXZDYoQ2c6bmbF4_QTNGNakEJ_wpmlHeiIo28tsxOklpRwiXTOln6JhTIWpFmhn6eQ1xGvAlxOizH_ESDtCnt_gcr0KGMXvb4_c-DDZ-h4hzwF9gHyGVCV5sfd9VN1N0IWeoVtNmi69diIDtEMYNvgAXhj2MyWbo8NIfCmDhY9yG5BNe2ewLJT1HR2vbJ3hx_56ir5cfbhafquXnj1eL82XlBBO5kop0tm2JljVvwRIHotOOlg9RNXNiTTVtG66gtUryrng6UnctdZKIFlrCT9G7O-5-agfoXNkdbW_20ZdstyZYb_6djH5rNuFglNI1Y6wAzu4BMfyYIGUz-OSg7-0IYUqGMU2kpEr_3vX6P-kuTHEs8QyTRaNpTWRRkTuViyGlCOvHYygxf-o1D_UapgwzdbG8-jvEo-GhT_4Loj6kLA</recordid><startdate>20190301</startdate><enddate>20190301</enddate><creator>Sungkar, Taufik</creator><creator>Rozi, Muhammad Fakhrur</creator><creator>Dairi, Leo Basa</creator><creator>Zain, Lukman Hakim</creator><general>Universiti Sains Malaysia Press</general><general>Penerbit Universiti Sains Malaysia</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BVBZV</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20190301</creationdate><title>Serum Ferritin Levels: A Potential Biomarker to Represent Child-Turcotte-Pugh Score among Decompensated Liver Cirrhosis Patients</title><author>Sungkar, Taufik ; Rozi, Muhammad Fakhrur ; Dairi, Leo Basa ; Zain, Lukman Hakim</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c424t-560dabb08573bea0ce4d8c1a0c0672c4f181b936eba653d424d07db1c504beb03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Ascites</topic><topic>Biomarkers</topic><topic>Esophagus</topic><topic>Hepatitis B</topic><topic>Hospitals</topic><topic>Infections</topic><topic>Inflammation</topic><topic>Laboratories</topic><topic>Liver cirrhosis</topic><topic>Liver diseases</topic><topic>Males</topic><topic>Malik, Adam</topic><topic>Medical records</topic><topic>Medical research</topic><topic>Mortality</topic><topic>Original</topic><topic>Patients</topic><topic>Viral infections</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sungkar, Taufik</creatorcontrib><creatorcontrib>Rozi, Muhammad Fakhrur</creatorcontrib><creatorcontrib>Dairi, Leo Basa</creatorcontrib><creatorcontrib>Zain, Lukman Hakim</creatorcontrib><creatorcontrib>Department of Internal Medicine, Gastroenterology-Hepatology Division, Universitas Sumatera Utara, Padang Bulan, Medan, Indonesia</creatorcontrib><creatorcontrib>Faculty of Medicine, Universitas Sumatera Utara, Padang Bulan, Medan, Indonesia</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>East & South Asia Database</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Malaysian journal of medical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sungkar, Taufik</au><au>Rozi, Muhammad Fakhrur</au><au>Dairi, Leo Basa</au><au>Zain, Lukman Hakim</au><aucorp>Department of Internal Medicine, Gastroenterology-Hepatology Division, Universitas Sumatera Utara, Padang Bulan, Medan, Indonesia</aucorp><aucorp>Faculty of Medicine, Universitas Sumatera Utara, Padang Bulan, Medan, Indonesia</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum Ferritin Levels: A Potential Biomarker to Represent Child-Turcotte-Pugh Score among Decompensated Liver Cirrhosis Patients</atitle><jtitle>The Malaysian journal of medical sciences</jtitle><addtitle>Malays J Med Sci</addtitle><date>2019-03-01</date><risdate>2019</risdate><volume>26</volume><issue>2</issue><spage>59</spage><epage>65</epage><pages>59-65</pages><issn>1394-195X</issn><eissn>2180-4303</eissn><abstract>Liver cirrhosis and the child-Turcotte-Pugh (CTP) score are inseparable entities in liver disease. CTP score is largely known as the mortality and prognosis predictor. Nevertheless, ferritin emerges as a simple biomarker related to prognosis. The study aimed to determine whether there was a significant correlation between serum ferritin levels and CTP score.
The study analysed 54 decompensated liver cirrhotic patients including 17 females and 37 males between May 2016 and May 2017 at the Haji Adam Malik General Hospital, Medan, Indonesia. Ferritin levels were, then, divided into trichotomous cut-off value (< 200 ng/mL,
= 22; 200-400 ng/mL,
= 5; and > 400 ng/mL,
= 27). Data was analysed using SPSS version 12.0 (continuous variables were assessed by the Kruskal-Wallis test and Chi-square test was used for categorical variables). In addition, Spearman correlation test was used to determine any significant correlation between ferritin levels and CTP score.
Based on data analysis, gender and CTP score were related to higher ferritin levels (
= 0.002 and
= 0.018, respectively). Furthermore, a significant correlation between serum ferritin levels and CTP score was obtained in to moderate degree (
= 0.000;
= 0.487).
There might be a significant role of serum ferritin levels in predicting mortality and prognosis among decompensated liver cirrhosis patients but it still needs further attention.</abstract><cop>Malaysia</cop><pub>Universiti Sains Malaysia Press</pub><pmid>31447609</pmid><doi>10.21315/mjms2019.26.2.7</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Malaysian journal of medical sciences, 2019-03, Vol.26 (2), p.59-65 |
| issn | 1394-195X 2180-4303 |
| language | eng |
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| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Bioline International; PubMed Central |
| subjects | Ascites Biomarkers Esophagus Hepatitis B Hospitals Infections Inflammation Laboratories Liver cirrhosis Liver diseases Males Malik, Adam Medical records Medical research Mortality Original Patients Viral infections |
| title | Serum Ferritin Levels: A Potential Biomarker to Represent Child-Turcotte-Pugh Score among Decompensated Liver Cirrhosis Patients |
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