Synaptogenesis Stimulates a Proteasome-Mediated Ribosome Reduction in Axons

Ribosomes and a subset of cellular mRNAs are trafficked into axons of developing neurons. The axonal localization of translational machinery allows new proteins to be rapidly and locally synthesized during axonal growth and pathfinding. However, in mature neurons, axonal ribosomes are significantly...

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Veröffentlicht in:	Cell reports (Cambridge) 2019-07, Vol.28 (4), p.864-876.e6
Hauptverfasser:	Costa, Rui O., Martins, Helena, Martins, Luís F., Cwetsch, Andrzej W., Mele, Miranda, Pedro, Joana R., Tomé, Diogo, Jeon, Noo Li, Cancedda, Laura, Jaffrey, Samie R., Almeida, Ramiro D.
Format:	Artikel
Sprache:	eng
Schlagworte:	axonal maturation co-cultures neuromuscular junction presynaptic differentiation proteasome ribosomal proteins ribosome synapse formation synaptogenesis UPS
Online-Zugang:	Volltext
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